Composition and biological activity of the Algerian plant Rosa canina L. by HPLC-UV-MS

Fetni, Samira; Bertella, Nabil; Ouahab, Ammar; Zapater, José Miguel Martı́nez; Fernández, Sonia de Pascual-Teresa

doi:10.1016/j.arabjc.2017.09.013

Cited by 38 publications

(31 citation statements)

References 33 publications

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“…Comparing these results with those from our previous study (Arris site) (Fetni et al, 2020), the yield of the ethanolic extract obtained by the ultrasound method was 20% and the concentration of total phenolic content was 354.46 ± 0.05 μg EAG/mg. The effect of various solvents to improve the extraction yield by methanol can be explained by the simple fact that methanol has a higher polarity index (6.6) compared with ethanol (5.2).…”

Section: Discussionsupporting

confidence: 81%

“…The DPPH radical scavenging effect was measured according to the method described by Fetni, Bertella, Ouahab, Zapater, and Fernadez (2020). DPPH is a stable organic nitrogen radical and has a maximum absorption at 517 nm.…”

Section: Methodsmentioning

confidence: 99%

“…There are a few studies that have contributed to the identification and characterization of bioactive compounds. Among the compounds identified so far are phenolic acids, flavones/ols, flavan3‐ols and also anthocyanins (Hvattum, 2002; Stănilă et al, 2015), flavonoids, carotenoids and fatty acids (Winther, Vinther Hansen, & Campbell‐Tofte, 2016), and phenolic acids, terpenoids and flavonoids (Fetni, Bertella, Ouahab, Zapater, & Fernandez, 2020). The importance of R. canina flavonoids/isoflavonoids is currently less clear.…”

Section: Introductionmentioning

confidence: 99%

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LC–DAD/ESI–MS/MS characterization of phenolic constituents in Rosa canina L. and its protective effect in cells

Fetni

Bertella

Ouahab

2020

Biomedical Chromatography

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In an aim to prove the efficiency of polyphenols of Rosa canina fruits in promoting human health. A methanolic extract of R. canina fruits was prepared by successive maceration with solvents of increasing polarity. The polyphenol composition was analyzed by HPLC–DAD–ESI–MS. The biological activity of this extract on SH‐SY5Y cells and HepG2 cells was then studied. The antioxidant activity was tested by various in vitro tests such as DPPH‐radical‐scavenging activity, FRAP assay, hydroxyl radical scavenging assay and total antioxidant capacity. The subacute toxicity of R. canina was tested on female rats by repeated intraperitoneal administration of various doses. The phenolic profiles showed 25 antioxidants distributed into three classes of phenolic compounds: glycosylated and agglomerated flavonoids/isoflavonoids, tannins and phenanthrenes. Qualitative phytochemical analyses showed that this extract lacks alkaloids. The methanolic extract of R. canina fruits has a total antioxidant capacity of 82.69 ± 1.18 μg EAA/mg of methanol extract and the IC50 of the methods used is in the following increasing order: FRAP assay (61.88 μg/ml), then hydroxyl radical scavenging assay (67.45 μg/ml) and then DPPH radical‐scavenging activity (129.81 μg/ml). The extract of R. canina did not cause any phenotypic signs of toxicity or mortality during and after treatment. The LD50 was >5,000 mg/kg, hence, R. canina was considered nontoxic. An in vivo study proved the protective effect of R. canina against cardiac and hepato‐renal toxicities. These results drew the importance of a healthy diet, where diets rich in R. canina fruits can be used as a rich natural source of antioxidants and anticarcinogenic phenolic compounds.

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Section: Discussionsupporting

confidence: 81%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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LC–DAD/ESI–MS/MS characterization of phenolic constituents in Rosa canina L. and its protective effect in cells

Fetni

Bertella

Ouahab

2020

Biomedical Chromatography

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“…Dog rose ( Rosa canina L.) is one of the most widespread species of Rosaceae family in Africa, Asia, Europe, and North America (Czyzowska, Klewicka, Pogorzelski, & Nowak, 2015; Fascella et al, 2019; Fetni et al, 2020). It is traditionally used in preventive medicine for colds, flu and diabetes (Cakilcioglu, Khatun, Turkoglu, & Hayta, 2011).…”

Section: Introductionmentioning

confidence: 99%

Modeling and optimization of drying conditions of dog rose for preparation of a functional tea

Pashazadeh

Zannou

Koca

2020

J Food Process Engineering

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Dog rose (Rosa canina L.) is a rosehip used for domestic and industrial purposes. It has great antioxidant compounds such as lycopene and phenolic compounds. In the present study, technological processing was investigated to formulate a functional tea with great nutraceutical compounds. The drying conditions were optimized to have maximum antioxidant properties. The optimum conditions were 68°C and 1 m s−1, providing the values of 40751.17 mg GAE/kg, 14.17 mg EGC E/100 g, 278.87 mmol TE/g, 44.62 mmol ISE/g, 3051.36 mg/kg, and 13.28 mg/kg for TPC, TFC, DPPH radical scavenging, FRAP, ascorbic acid, and lycopene, respectively. Midilli model described well the drying behavior of Dog rose and, Peleg, Weibull and Vega‐galves models predicted well the rehydration kinetics. A two‐factor and central composite design was applied to evaluate the effects of decoction time and solid‐to‐liquid ratio. At the optimal conditions, the Dog rose tea had 98141.28 mg GAE/kg, 2720.66 mg EGC E/100 g, 8616.57 mmol TE/g, 728.24 mmol ISE/g; and 3,358 for TPC, TFC, DPPH radical scavenging, FRAP, and ascorbic acid content, respectively. The findings showed that Dog rose fruit is a great source of nutraceutical compounds and a potential industrial product. Practical application The drying conditions to have a dried fruit with high antioxidant properties were determined. The dried Dog rose fruit is stable for long storage period and be afforded in off‐seasons. Optimization and mathematical models were successfully applied to determine the optimum drying conditions and to predict the drying and rehydration kinetics, respectively. Midilli model was the most fitted model to predict the drying kinetics, while, Peleg, Vegas‐gálves and Weibull models depicted better the rehydration kinetics at 20, 40, and 60°C. The dried fruit can be used in food, cosmetic, and pharmaceutical industries for many purposes. A functional fruit tea was formulated and optimized for its nutraceutical properties. This tea is a functional food used as a natural preventive remedy for flu, cancer, anemia, cardiovascular diseases and diabetes as well.

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“…No comparisons were found in the literature regarding the TPC-FC and TPC-FBBB methods for freeze-dried pitaya peel; however, several other plant sources were compared and all these studies pointed higher values for the Fast Blue BB test in comparison with the Folin-Ciocalteau test (Medina, 2011;Kang et al, 2012;Lester et al, 2012;Fetni et al, 2017). According to Medina (2011), the TPC-FBBB method quantified concentrations up to 6.6 times higher in beverages and grain samples than the TPC-FC test; Fetni et al 2017found concentrations up to 1.7 times higher by the TPC-FBBB method, in a sample of Rosa canina L.; Lester et al (2012) identified values 2.9 times higher in strawberry samples; and Kang et al (2012) quantified values of up to 3.4 times higher in an açaí sample.…”

Section: Optimization Of the Extraction Of Phenolic Compounds Flavonmentioning

confidence: 99%

Optimization of solid-liquid extraction of polar substances from pitaya peel flour

Lara

Costa

Coringa

2020

Agraria

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Pitaya, or dragon fruit, (Hylocereus polyrhizus) contains in its pulp and peel a high concentration of phenolic compounds, flavonoids and high antioxidant activity. The pulp is used in industries and the peel can be a source of bioactive compounds. The aim of this study was to optimize the extraction of phenolic compounds from pitaya peel flour, dried through freeze-drying. Thus, a central composite rotatable design (CCRD) was performed with two variables (X 1 = ethanol percentage, of 0-100% as extraction solvent; X 2 = extraction time, of 5-120 minutes assisted by ultrasound) resulting in 11 experiments. The response variables were the content of total phenolic compounds by the methods of Folin-Ciocalteau and Fast Blue BB, total flavonoids and antioxidant activity by capture of radicals 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid); 2,2-diphenyl-1-picrylhydrazyl (DPPH); reduction of iron III (FRAP). It was possible to design the response surface for the analysis of total flavonoids and ABTS. The region of optimal flavonoids extraction, where the extract also demonstrated greater antioxidant activity by the ABTS method, is comprised between 13 and 57% of the ethanol as a solvent and time above 86 minutes of extraction in ultrasonic bath.

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Composition and biological activity of the Algerian plant Rosa canina L. by HPLC-UV-MS

Cited by 38 publications

References 33 publications

LC–DAD/ESI–MS/MS characterization of phenolic constituents in Rosa canina L. and its protective effect in cells

LC–DAD/ESI–MS/MS characterization of phenolic constituents in Rosa canina L. and its protective effect in cells

Modeling and optimization of drying conditions of dog rose for preparation of a functional tea

Optimization of solid-liquid extraction of polar substances from pitaya peel flour

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