Composition and Function of the Extracellular Matrix in the Human Body

Abstract

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Reaching the Tumor: Mobility of Polymeric Micelles Inside an In Vitro Tumor-on-a-Chip Model with Dual ECM

“…The basal lamina is a thin ECM layer that creates the inner lining of many epithelial, muscle, and endothelial tissues, including the walls of blood vessels. The basal lamina is an intertwined mesh of laminin and collagen type IV, cross-linked by several connecting molecules, such as enactin and the heparan sulfate-containing perlecan complex . The reticular meshlike structure of the basal lamina is very different from the ECM typically found inside tumors.…”