Insights into current directions of protein and peptide-based hydrogel drug delivery systems for inflammation

Bertilla, X. Janet; Rupachandra, S

doi:10.1007/s00289-022-04527-1

Cited by 6 publications

(2 citation statements)

References 119 publications

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“…The use of materials that combine the properties of PL with those of biomolecules is of high interest for bio-applications [ 15 , 22 , 23 , 24 , 25 ]. Usually, polysaccharides, proteins, or peptides are used for the design of composite hydrogels in order to enhance biological performances, including antimicrobial properties [ 26 , 27 , 28 , 29 , 30 ], to increase gel strength and bioadhesive properties [ 31 ], or these biomolecules are added to improve the residence time of the active compounds in tissues [ 15 , 24 ]. In the presence of polysaccharides, the morphological analysis revealed a denser structure with smaller pores as compared with PL pristine gels [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Temperature Induced Gelation and Antimicrobial Properties of Pluronic F127 Based Systems

Lupu¹,

Roșca²,

Gradinaru

et al. 2023

Polymers

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Different formulations containing Pluronic F127 and polysaccharides (chitosan, sodium alginate, gellan gum, and κ-carrageenan) were investigated as potential injectable gels that behave as free-flowing liquid with reduced viscosity at low temperatures and displayed solid-like properties at 37 °C. In addition, ZnO nanoparticles, lysozyme, or curcumin were added for testing the antimicrobial properties of the thermal-sensitive gels. Rheological investigations evidenced small changes in transition temperature and kinetics of gelation at 37 °C in presence of polysaccharides. However, the gel formation is very delayed in the presence of curcumin. The antimicrobial properties of Pluronic F127 gels are very modest even by adding chitosan, lysozyme, or ZnO nanoparticles. A remarkable enhancement of antimicrobial activity was observed in the presence of curcumin. Chitosan addition to Pluronic/curcumin systems improves their viscoelasticity, antimicrobial activity, and stability in time. The balance between viscoelastic and antimicrobial characteristics needs to be considered in the formulation of Pluronic F127 gels suitable for biomedical and pharmaceutical applications.

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Section: Introductionmentioning

confidence: 99%

Temperature Induced Gelation and Antimicrobial Properties of Pluronic F127 Based Systems

Lupu¹,

Roșca²,

Gradinaru

et al. 2023

Polymers

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“…7 Usually, peptides and polysaccharides are combined with PF-127 to enhance their antimicrobial and biological properties. 8,9 It has been used as a drug delivery agent for various anti-neoplastic drugs, 10 lignocaine, 11 and as a dressing material for thermal burn wounds. 12 PF-127 is also used as a carrier for drug delivery in ophthalmology.…”

Section: Introductionmentioning

confidence: 99%

In vitro Antimicrobial Properties of Pluronic F-127 Injectable Thermoresponsive Hydrogel

Sharun¹,

Nair²,

Banu³

et al. 2023

J. Pure Appl. Microbiol.

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Pluronic F-127 (PF-127) hydrogel is a versatile biomaterial with promising applications in drug delivery, tissue engineering, and regenerative medicine. PF-127 has antiadhesive activity that prevents bacterial adhesion by creating a hydrated layer on the bacterial surface. This property makes PF-127 suitable for preventing implant-associated infections. In this study, we aimed to evaluate the antibacterial properties of PF-127 using field isolates of Staphylococcus aureus (Gram-positive bacteria) and Escherichia coli (Gram-negative bacteria) and compare them with different antibiotic standards. The antimicrobial potential was assessed using disk diffusion assays with four standard concentrations (20%, 25%, 30%, and 40%). The test microorganisms were inoculated on agar plates, and sterile filter paper disks infused with PF-127 hydrogels were placed alongside standard antibiotic disks. After incubation, the inhibition zones were measured to determine antimicrobial activity. Our results showed that PF-127 lacked intrinsic antimicrobial activity against S. aureus and E. coli at the tested concentrations. In conclusion, PF-127 hydrogel is a promising neutral carrier hydrogel system for loading antibiotics and antimicrobial compounds. Its unique properties, such as biocompatibility and thermo-responsive behaviour, combined with its antiadhesive activity, make it an ideal candidate for various biomedical applications.

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A new candidate for wound dressing materials: s-IPN hydrogel-based highly elastic and pH-sensitive drug delivery system containing pectin and vinyl phosphonic acid

Şeref,

Ilgin,

Ozay

et al. 2024

European Polymer Journal

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Insights into current directions of protein and peptide-based hydrogel drug delivery systems for inflammation

Cited by 6 publications

References 119 publications

Temperature Induced Gelation and Antimicrobial Properties of Pluronic F127 Based Systems

Temperature Induced Gelation and Antimicrobial Properties of Pluronic F127 Based Systems

In vitro Antimicrobial Properties of Pluronic F-127 Injectable Thermoresponsive Hydrogel

A new candidate for wound dressing materials: s-IPN hydrogel-based highly elastic and pH-sensitive drug delivery system containing pectin and vinyl phosphonic acid

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