Composition and functions of bacterial membrane vesicles

Toyofuku, Masanori; Schild, Stefan; Kaparakis‐Liaskos, Maria; Eberl, Leo

doi:10.1038/s41579-023-00875-5

Cited by 204 publications

(134 citation statements)

References 208 publications

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“…Whereas P. aeruginosa cells undergo complete disintegration, the thick Gram-positive cell wall of B. subtilis is not entirely hydrolyzed, although most cells die owing to a loss of membrane integrity caused by the endolysins and autolysins, evidenced by the formation of ghost cells and intracellular CMVs. [8,35] The phenomenon is also named "bubbling cell death", which is frequently found in other Gram-positive bacteria such as Lactococcus lactis, [41] Streptococcus suis, [42] and group A Streptococcus. [43] Besides endolysin, autolysins are another factor induced under stress conditions by peptidoglycan-hydrolyzing enzymes or 𝛽-lactam antibiotics (Figure 1⑧).…”

Section: Bmv Formation Through Explosive Cell Lysis and Bubbling Cell...mentioning

confidence: 99%

“…[18] It is worth noting that the same bacteria can produce different types of vesicles via distinct biogenetic pathways, which holds truth for both Gram-positive and Gram-negative bacteria, mycobacteria, and fungi. [8,19] In addition to their contribution to bacterial infections and pathogenesis, BMVs are increasingly attractive to be new delivery nanoplatforms for various vaccines and drugs, a hot area of research in the past decade. [20] In the current review, we summarize the roles of various BMVs in infections, antibiotic resistance, and pathogenesis, and discuss recent advances with respect to their applications in a reversal of antibiotic resistance, vaccine designs, and drug delivery.…”

Section: Introductionmentioning

confidence: 99%

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Bacterial Membrane Vesicles: Physiological Roles, Infection Immunology, and Applications

et al. 2023

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Bacterial or fungal membrane vesicles, traditionally considered as microbial metabolic wastes, are secreted mainly from the outer membrane or cell membrane of microorganisms. However, recent studies have shown that these vesicles play essential roles in direct or indirect communications among microorganisms and between microorganisms and hosts. This review aims to provide an updated understanding of the physiological functions and emerging applications of bacterial membrane vesicles, with a focus on their biogenesis, mechanisms of adsorption and invasion into host cells, immune stimulatory effects, and roles in the much‐concerned problem of bacterial resistance. Additionally, the potential applications of these vesicles as biomarkers, vaccine candidates, and drug delivery platforms are discussed.

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Section: Bmv Formation Through Explosive Cell Lysis and Bubbling Cell...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bacterial Membrane Vesicles: Physiological Roles, Infection Immunology, and Applications

et al. 2023

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“…Other biobased nanoparticles, such as bacterial outer membrane-derived particles, naturally present immunostimulatory content and can act as the vaccine. − Noh et al exploited this property to engineer a vaccine platform for treating bacterial infection . Here, nanodiscs were fabricated from the outer membrane of Pseudomonas aeruginosa and were then used as a vaccination platform against pneumonia (Figure a).…”

Section: Potential Applicationsmentioning

confidence: 99%

Tailoring the Inherent Properties of Biobased Nanoparticles for Nanomedicine

Zahid

Chakraborty

Luo

et al. 2023

ACS Biomater. Sci. Eng.

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Biobased nanoparticles are at the leading edge of the rapidly developing field of nanomedicine and biotherapeutics. Their unique size, shape, and biophysical properties make them attractive tools for biomedical research, including vaccination, targeted drug delivery, and immune therapy. These nanoparticles are engineered to present native cell receptors and proteins on their surfaces, providing a biomimicking camouflage for therapeutic cargo to evade rapid degradation, immune rejection, inflammation, and clearance. Despite showing promising clinical relevance, commercial implementation of these biobased nanoparticles is yet to be fully realized. In this perspective, we discuss advanced biobased nanoparticle designs used in medical applications, such as cell membrane nanoparticles, exosomes, and synthetic lipid-derived nanoparticles, and highlight their benefits and potential challenges. Moreover, we critically assess the future of preparing such particles using artificial intelligence and machine learning. These advanced computational tools will be able to predict the functional composition and behavior of the proteins and cell receptors present on the nanoparticle surfaces. With more advancement in designing new biobased nanoparticles, this field of research could play a key role in dictating the future rational design of drug transporters, thereby ultimately improving overall therapeutic outcomes.

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“…88 This observation has interesting implications for current debates regarding the presence of peptidoglycan (PG) on the surface of CMVs. 84,87,89,90 As a parallel to LPSs for OMVs, PG would seemingly be the most dominant and most external component of CMVs. However, the lack of detected WTAs on the surface of CMVs suggests that some regions of PG, or at least some PG-bound material, is excluded from CMVs.…”

Section: Physical Characteristics Of Evsmentioning

confidence: 99%

Extracellular Vesicles and Bacteriophages: New Directions in Environmental Biocolloid Research

Hicks,

Rogers,

Hendren

et al. 2023

Environ. Sci. Technol.

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There is a long-standing appreciation among environmental engineers and scientists regarding the importance of biologically derived colloidal particles and their environmental fate. This interest has been recently renewed in considering bacteriophages and extracellular vesicles, which are each poised to offer engineers unique insights into fundamental aspects of environmental microbiology and novel approaches for engineering applications, including advances in wastewater treatment and sustainable agricultural practices. Challenges persist due to our limited understanding of interactions between these nanoscale particles with unique surface properties and their local environments. This review considers these biological particles through the lens of colloid science with attention given to their environmental impact and surface properties. We discuss methods developed for the study of inert (nonbiological) particle–particle interactions and the potential to use these to advance our understanding of the environmental fate and transport of extracellular vesicles and bacteriophages.

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Composition and functions of bacterial membrane vesicles

Cited by 204 publications

References 208 publications

Bacterial Membrane Vesicles: Physiological Roles, Infection Immunology, and Applications

Bacterial Membrane Vesicles: Physiological Roles, Infection Immunology, and Applications

Tailoring the Inherent Properties of Biobased Nanoparticles for Nanomedicine

Extracellular Vesicles and Bacteriophages: New Directions in Environmental Biocolloid Research

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