Composition, <i>in vitro</i> Cytotoxicity, Anti-mildew and Anti-wood-decay Fungal Activities of the Fruit Essential Oil of <i>Liquidambar formosana</i> from Taiwan

Su, Yu-Chang; Ho, Chyi-Chen

doi:10.1177/1934578x1701200237

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…Among eight products of SchTPS6, all seven previously elucidated compounds including 7 , , 9 , 15 , 22 , , 24 , 26, , and 27 , ,, possess insecticidal, fungicidal, and/or herbicidal activities (Figure A, C). Hence, we sought to enhance their production in yeast, which may lay a foundation for the development of agrochemical mixtures.…”

Section: Resultsmentioning

confidence: 97%

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Characterization of SchTPSs Enables Construction of Yeast for the Bioproduction of α-Cadinol and the Related Sesquiterpenes

Gao,

Lin,

et al. 2023

J. Agric. Food Chem.

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Plant volatile sesquiterpenes (PVSs) play important roles in chemical plant defense. However, it is difficult to isolate sufficient PVSs for deep investigations due to their low contents and chemical and physical properties close to those of other lipids. The extracts of Stellera chamaejasme L. exhibit insecticidal, fungicidal, and allelopathic activities. In this study, we identified three sesquiterpene synthase genes (SchTPS5, SchTPS6, and SchTPS7) from S. chamaejasme L. SchTPS7 is an α-farnesene synthase. SchTPS5 and SchTPS6 are two catalytically promiscuous sesquiterpene synthases, and α-cadinol and τ-muurolol are the predominant products for both of them in Saccharomyces cerevisiae. This study, for the first time, reports plant sesquiterpene synthases capable of producing α-cadinol and/or τ-muurolol in a heterologous host. More intriguingly, seven out of eight products of SchTPS6 in S. cerevisiae possess various insecticidal, fungicidal, and herbicidal activities. Building on this finding, we used SchTPS6 to construct an engineered S. cerevisiae for the production of these sesquiterpenes. The titers of two major products α-cadinol and τ-muurolol, respectively, reached 46.2 ± 4.0 and 11.2 ± 1.4 mg/L in a flask. This study lays a foundation for the development of new agrochemical mixtures.

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Section: Resultsmentioning

confidence: 97%

“…Intriguingly, seven out of eight products of SchTPS6 in S. cerevisiae were reported to have insecticidal, fungicidal, and/or herbicidal activities. ,,− We next constructed an engineered S. cerevisiae in which the titers of two major products α-cadinol and τ-muurolol reached 46.2 ± 4.0 and 11.2 ± 1.4 mg/L, respectively.…”

Section: Introductionmentioning

confidence: 99%

Characterization of SchTPSs Enables Construction of Yeast for the Bioproduction of α-Cadinol and the Related Sesquiterpenes

Gao,

Lin,

et al. 2023

J. Agric. Food Chem.

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“…For instance, bark essential oil of Cunninghamia lanceolate var. konishii 6 and fruit oil of Liquidambar formosana 7 have excellent resistance to wood decay fungi. These oils can fully inhibit the growth of Trametes versicolor , Phanerochaete chrysosporium , Phaeolus schweinitzii , and Lenzites sulphureu at a dose of only 100 μg/mL.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and In Vitro Anti-Wood-Decay Fungal Activities of Dysphania ambrosioides Leaf Essential Oil From Taiwan

Hsu

Yang

Wei

et al. 2022

Natural Product Communications

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We evaluated the leaf essential oil in whole or fractions of Dysphania ambrosioides with respect to their resistance to wood decay fungal activities in vitro of 4 fungi. The main ingredients with the greater anti-wood decay capability were also identified. Fresh leaves of D. ambrosioides were hydrodistillated in a Clevenger-type apparatus and the resulting oil characterized using GC-FID and GC-MS instruments. The essential oil was found to consist of α-terpinene (30.5%), p-cymene (17.3%), carvacrol (16.2%), and ascaridole (15.1%). The oil showed resistance to wood decay activity of Trametes versicolor, Phanerochaete chrysosporium, Phaeolus schweinitzii, and Lenzites sulphureu. The oil had excellent resistance to wood decay fungal activities, and the active compounds were shown to be carvacrol and ascaridole.

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“…The fruits of L. formosana have yielded lupane and oleanane triterpenoids [ 6 ]. The fruit essential oil has shown antifungal activity and was dominated by α-pinene (16.8%), ( E )-caryophyllene (10.1%), τ-muurolol (8.3%), τ-cadinol (7.6%), β-pinene (6.7%), and sabinene (5.7%) [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Essential Oil Composition and Antimicrobial Activity of Liquidambar formosana Oleoresin

DeCarlo

Zeng

Dosoky

et al. 2020

Plants

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The oleoresin essential oils of Liquidambar formosana have potential therapeutic benefits. However, current research on L. formosana oleoresin essential oil is still in its early stages, and its chemotypic characterization is undefined. For better leveraging of plant resources and application of the essential oil, we collected 25 L. formosana oleoresin essential oil samples of individual trees from different geographical areas of Southern China. The essential oils were obtained by hydrodistillation and analyzed by gas chromatography–mass spectrometry (GC–MS) and gas chromatography–flame ionization detection (GC–FID). The major components of the essential oils were (E)-caryophyllene (3.3%-64.4%), α-pinene (0.6%-34.5%), β-pinene (0.6%-26.0%), camphene (0.3%-17.3%), and limonene (0.2%-7.9%). A chiral GC–MS analysis was carried out on the essential oil samples and (–)-α-Pinene, (–)-β-pinene, (–)-camphene, and (–)-limonene were the dominant enantiomers in L. formosana essential oil. The chemical categories of L. formosana oleoresin essential oils were clarified by agglomerative hierarchical cluster analysis (AHC) and principal component analysis (PCA). The multivariate analyses demonstrated that a total of four chemical groups can be delineated for L. formosana. The L. formosana essential oils were screened for antimicrobial activity against a panel of potentially pathogenic bacteria and fungi and showed promising antimicrobial activities with minimum inhibitory concentration (MIC) ≤ 625 μg/mL. These results highlight the economic value of L. formosana oleoresin essential oil, the importance of L. formosana sustainability, and the potential therapeutic benefits of its oleoresin essential oils.

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Composition, in vitro Cytotoxicity, Anti-mildew and Anti-wood-decay Fungal Activities of the Fruit Essential Oil of Liquidambar formosana from Taiwan

Cited by 4 publications

References 19 publications

Characterization of SchTPSs Enables Construction of Yeast for the Bioproduction of α-Cadinol and the Related Sesquiterpenes

Characterization of SchTPSs Enables Construction of Yeast for the Bioproduction of α-Cadinol and the Related Sesquiterpenes

Chemical Composition and In Vitro Anti-Wood-Decay Fungal Activities of Dysphania ambrosioides Leaf Essential Oil From Taiwan

The Essential Oil Composition and Antimicrobial Activity of Liquidambar formosana Oleoresin

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