Composition of Death Risk According to Behavioral Factors (Smoking, Alcohol Consumption) by the Results of 27-Year Prospective Study

Иванова, А. Ю.; Долгалёв, И. В.

doi:10.15829/1728-8800-2017-5-40-45

Cited by 11 publications

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“…По итогам 27-летнего проспективного когортного наблюдения, АГ и частое употребление алкоголя являются значимыми независимыми предикторами преждевременной смерти [8,10], что согласуется с данными многих крупных исследований, в которых установлены высокие показатели ОР смерти от ССЗ и от всех причин у лиц, имеющих эти ФР [16,17]. Выявленное нами увеличение ОР смерти при сочетании АГ и частого употребления алкоголя также соответствует современным представлениям о сочетанном влиянии ФР на заболеваемость и смертность [7,9,18].…”

Section: Discussionunclassified

“…Показано, что частое употребление алкоголя оказывает значительное влияние на формирование риска смерти от всех причин (ОР 2,55; p<0,001), что справедливо как для мужчин (ОР 1,79; p<0,05), так и для женщин (ОР 3,84; p<0,01) [8]. При изучении влияния употребления алкоголя на смертность от ССЗ установлено, что частое употребление алкоголя существенно повышает риск преждевременной смерти у лиц в возрасте 20-39 лет (ОР 5,69; p<0,05).…”

Section: результатыunclassified

“…В нашей стране фактором, вносящим наиболее значительный вклад в формирование сердечно-сосудистой за-болеваемости и смертности, является АГ [3,6]. Вместе с тем избыточное употребление алкоголя -один из влиятельных предикторов многих соматических заболеваний, который вносит существенный вклад в формирование сердечно-сосудистой и общей смертности, однако до настоящего времени этот ФР нездорового образа жизни не отнесен к конвенционным и не включен в прогностические модели риска [5,7,8].…”

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“…В современном мире АГ и избыточное употребление алкоголя широко распространены и часто сочетаются друг с другом. Однако имеется мало информации об их совместном воздействии на основные неблагоприятные события, особенно у молодых взрослых людей, поскольку для установления взаимосвязи употребления ал-ОРИГИНАЛЬНЫЕ СТАТЬИ § коголя, ССЗ и смертности требуется длительный период наблюдения [7][8][9][10]. Сведения о сочетанном влиянии АГ и избыточного употребления алкоголя на формирование риска смерти представлены в единичных сообщениях [11].…”

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Combined Effect of Hypertension and Alcohol Consumption on the Risk of Death (27‑Year Cohort Prospective Study)

et al. 2021

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Aim To study the effect of arterial hypertension (AH) in combination with frequent alcohol consumption on the formation of risk for cardiovascular death and all-cause death according to results of a 27-year prospective cohort study.Material and methods This 27‑year prospective cohort study of an unorganized population of the Tomsk city (1546 people aged 20–59 years, including 630 men and 916 women) investigated AH prevalence and alcohol consumption (1988–1991) and analyzed the predictive significance of the effect of AH in combination with frequent alcohol consumption on the formation of risk for all-cause and cardiovascular death. AH was diagnosed at blood pressure ≥140 / 90 mm Hg. Frequent alcohol users were defined as those who consumed alcohol more than once a week.Results The combination of AH and frequent alcohol consumption increased the risk of all-cause death 4.1 times compared to that for persons without these risk factors (p<0.001). This was true for all age groups of the total cohort (higher relative risk, RR, was observed for persons aged 20–39 years) and for men (except for the group aged 40–59 years). RR of cardiovascular death was 5.3 (p<0.001) for frequent alcohol users with AH. It was established that frequent alcohol consumption additionally increased RR of all-cause death for persons with AH (RR 1.89; p<0.05) primarily at the expense of persons aged 20-39 years. Prediction of 27‑year survival for frequent alcohol users with AH was 35.3 %.Conclusion A combination of AH with frequent alcohol consumption considerably increases the risk of all-cause and cardiovascular death. Frequent alcohol consumption significantly impairs the prediction of 27-year survival for persons with AH by additionally (1.9 times) increasing the risk of all-cause death. Binary AH combinations with frequent alcohol consumption exert a more pronounced adverse effect on young men and women.

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Combined Effect of Hypertension and Alcohol Consumption on the Risk of Death (27‑Year Cohort Prospective Study)

et al. 2021

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“…The long-term influence of demographic factors and risk factors (environmental, social, psychological, behavioral, etc.) on the health status of the population is studied in [16][17][18][19][20]. The effectiveness of healthcare reform and improving the quality of medical care are analyzed in [21][22][23][24].…”

Section: Introductionmentioning

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Approaches to Defining Scientific Priorities in Healthcare and Medicine: The Russian Experience

Matorin

Petrovsky

Проничкин

et al. 2021

Sci. Tech. Inf. Proc.

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Most countries use their own procedures for decision making, as well as collecting and analyzing information to determine scientific priorities in medicine. This paper describes the system of organization and management for healthcare and medical science in Russia. The procedures for forming scientific priorities in medicine in the post-Soviet period are described. The necessity of applying modern methods in the selection of scientific priorities is substantiated.

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Influence of arterial hypertension, smoking, and their combination on mortality (according to the results of a 27-year cohort prospective study of the unorganized population of Tomsk)

et al. 2019

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Aim. To study the influence of arterial hypertension (AH), smoking, and their combination on the risk of all cause and cardiovascular mortality.Material and methods. We conducted a 27-year cohort prospective study of the unorganized population of Tomsk (916 women and 630 men aged 20-59 years). At the first stage, we studied the prevalence of AH and smoking (1998-1991), at the second (2015) — the effect of these risk factors (RF) and their combination on the risk of all cause and cardiovascular mortality. AH was diagnosed at a blood pressure level of >140/90 mmHg and <140/90 mm Hg in individuals taking antihypertensive drugs. Smokers were individuals who smoked at least 1 cigarette per day and quit smoking less than one year ago.Results. The study found a significant effect of AH and smoking on mortality: the relative risk (RR) of all-cause mortality in people with hypertension was 2,2, in smokers — 2,3, in those with a combination of RF — 5,0. The RR of cardiovascular mortality in AH individuals was 3,4, in smokers — 1,6, in smoking men and women suffering from AH — 5,2. An increase in the risk of all-cause mortality in people with AH and smoking was observed in all gender-age groups. Smoking was found to increase the risk of all-cause mortality in individuals with high levels of blood pressure by 2,1 times compared with non-smoking hypertensive patients. It reduces the chances of a 27-year survival rate to 64,4%, and more so in the youngest (20-39 years) age group (RR — 3,9). Multivariate analysis showed that AH and smoking make the most significant contribution to the formation of mortality compared to other modifiable RFs.Conclusion. We found that AH and smoking are among the most influential RFs, and their combination increases the RR of all-cause mortality by 5,0 times (cardiovascular — 5,2 times). We also determined an additional risk of smoking in individuals suffering from AH to the all-cause mortality.

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Composition of Death Risk According to Behavioral Factors (Smoking, Alcohol Consumption) by the Results of 27-Year Prospective Study

Cited by 11 publications

References 0 publications

Combined Effect of Hypertension and Alcohol Consumption on the Risk of Death (27‑Year Cohort Prospective Study)

Combined Effect of Hypertension and Alcohol Consumption on the Risk of Death (27‑Year Cohort Prospective Study)

Approaches to Defining Scientific Priorities in Healthcare and Medicine: The Russian Experience

Influence of arterial hypertension, smoking, and their combination on mortality (according to the results of a 27-year cohort prospective study of the unorganized population of Tomsk)

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