Composition of Energy Metabolism Substrates Increases the Efficiency of Pharmacotherapy of Cardiovascular Diseases

Peskov, A.B.; Maevskii, E. I.; Uchitel, M. L.

doi:10.1007/s10517-005-0373-4

Bull Exp Biol Med

2005

DOI: 10.1007/s10517-005-0373-4

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Composition of Energy Metabolism Substrates Increases the Efficiency of Pharmacotherapy of Cardiovascular Diseases

A.B. Peskov

E. I. Maevskii

M. L. Uchitel

Abstract: The substrate composition containing succinic acid, substrates for succinate synthesis, and antioxidants increased the efficiency of pharmacotherapy in patients with coronary heart disease and hypertension. We revealed an increase in the quality of life and decrease in the functional class of heart failure, incidence of arrhythmias and exercise-related pain, and blood cholesterol concentration.

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Meta-analytic assessment of parenteral cytoflavin effectiveness in different neurologic disorders

Mazin¹,

Sheshunov²,

Mazina³

2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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An analysis of formalized efficacy indicators (increase in the absolute and relative value, odds ratio (OR) etc.) has demonstrated the advantages of cytoflavin. Group combination has increased the statistical power of the meta-analysis. Two models with fixed (Mantel-Haenszel amendment) and random effects were used. All the estimation protocols in different clinical groups of patients with neurologic diseases provided similar results and confirmed the stability of calculated values irrespective of heterogeneity of data arrays. OR of positive outcomes in neuropathologies treated with cytoflavin was 3,02 with χ2 heterogeneity 427,3 and p = 0,000…, I2= 85,7% (82%; 88%).

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Meta-analytic assessment of parenteral cytoflavin effectiveness in different neurologic disorders

Mazin¹,

Sheshunov²,

Mazina³

2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Maintenance of Homeostasis in the Aging Hypothalamus: The Central and Peripheral Roles of Succinate

2015

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Aging is the phenotype resulting from accumulation of genetic, cellular, and molecular damages. Many factors have been identified as either the cause or consequence of agerelated decline in functions and repair mechanisms. The hypothalamus is the source and a target of many of these factors and hormones responsible for the overall homeostasis in the body. With advanced age, the sensitivity of the hypothalamus to various feedback signals begins to decline. In recent years, several aging-related genes have been identified and their signaling pathways elucidated. These gene products include mTOR, IKK-β/NF-κB complex, and HIF-1α, an important cellular survival signal. All of these activators/modulators of the aging process have also been identified in the hypothalamus and shown to play crucial roles in nutrient sensing, metabolic regulation, energy balance, reproductive function, and stress adaptation. This illustrates the central role of the hypothalamus in aging. Inside the mitochondria, succinate is one of the most prominent intermediates of the Krebs cycle. Succinate oxidation in mitochondria provides the most powerful energy output per unit time. Extra-mitochondrial succinate triggers a host of succinate receptor (SUCN1 or GPR91)-mediated signaling pathways in many peripheral tissues including the hypothalamus. One of the actions of succinate is to stabilize the hypoxia and cellular stress conditions by inducing the transcriptional regulator HIF-1α. Through these actions, it is hypothesized that succinate has the potential to restore the gradual but significant loss in functions associated with cellular senescence and systemic aging.

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Composition of Energy Metabolism Substrates Increases the Efficiency of Pharmacotherapy of Cardiovascular Diseases

Cited by 2 publications

References 3 publications

Meta-analytic assessment of parenteral cytoflavin effectiveness in different neurologic disorders

Meta-analytic assessment of parenteral cytoflavin effectiveness in different neurologic disorders

Maintenance of Homeostasis in the Aging Hypothalamus: The Central and Peripheral Roles of Succinate

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