Understanding the dynamics of complex systems requires developing and combining different kinds of models that can be simulated separately and together. Modeling the interactions as separate models contributes to building flexible hybrid simulation frameworks. In this research, a Discrete Event System Specification–based Interaction Model (DEVS-IM) framework is developed based on the Knowledge Interchange Broker (KIB) approach. This KIB-based RESTful modeling composition framework is shown to enable systematic modeling and simulation of interactions between disparate simulatable models. It supports storing IMs developed for componentized Water Evaluation and Planning System (WEAP) and Low Emissions Analysis Platform (LEAP) tools. It generates the skeleton of DEVS-IMs stored in database for DEVS-Suite simulator. An exemplar model consisting of water, energy, and IMs demonstrates this methodology for developing nexus models of water–energy systems.