Composition of the Gut Microbiota in Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis

Wang, Ning; Gao, Xu; Zhang, Zifeng; Yang, Li

doi:10.3389/fendo.2022.838941

Cited by 25 publications

(22 citation statements)

References 36 publications

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“…According to the AMSTAR-2 criteria, 21 SRs [7,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] scored "critically low," 16 SR [13,[37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] scored "low," and 5 SR [36,[52][53][54][55] scored "moderate" (Figure 2). The most frequent drawbacks were as follows: no mentioning of the protocol in the systematic overview, no description of the rationale for the study designs included in the review, and no statement of funding for the included studies.…”

Section: Methodological Quality Of Included Studiesmentioning

confidence: 99%

“…Alzheimer's disease (AD) [31,40,41], 10 SRs included attention deficit hyperactivity disorder (ADHD) [17,19,22,37,39,45,46,49,51,53], 1 SR included amyotrophic lateral sclerosis (ALS) [21], 2 SRs included anorexia nervosa (AN) [36,45], 5 SRs included bipolar disorder (BD) [20,43,45,46,52], 1 SR included eating disorder (ED) [27], 2 SRs included generalized anxiety disorder (GAD) [45,46], 9 SRs included major depressive disorder (MDD) [20,23,26,28,33,45,46,52,56], 3 SRs included multiple sclerosis (MS) [13,25,54], 1 SR included obsessive compulsive disorder (OCD) [45], 6 SRs included Parkinson's disease (PD) [7,25,27,35,44,47], 2 SRs included posttraumatic stress disorder (PTSD) [45,46], 2 SRs included spinal cord Injury (SCI) [13,…”

Section: Mediators Of Inflammationmentioning

confidence: 99%

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The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders—An Evidence Mapping Based on Quantified Evidence

Zang

Lai

et al. 2023

Mediators of Inflammation

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Background and Object. There is a growing body of evidence highlighting the significant role of gut microbiota in various neurological and psychiatric disorders. We performed an evidence mapping to review the association between different microbiota and these disorders and assessed the strength of evidence for these associations. Methods. We searched PubMed, Cochrane Library, and Epistemonikos to identify systematic reviews and meta-analysis (SRs). We searched for neurological diseases and psychiatric disorders, including Alzheimer’s disease (AD), attention deficit hyperactivity disorder (ADHD), amyotrophic lateral sclerosis (ALS), autism spectrum disorder (ASD), anorexia nervosa (AN), bipolar disorder (BD), eating disorder (ED), generalized anxiety disorder (GAD), major depressive disorder (MDD), multiple sclerosis (MS), obsessive compulsive disorder (OCD), Parkinson’s disease (PD), posttraumatic stress disorder (PTSD), spinal cord injury (SCI), schizophrenia, and stroke. We used A Measurement Tool to Assess Systematic Reviews (AMSTAR-2) to evaluate the quality of included SRs. We also created an evidence map showing the role of gut microbiota in neurological diseases and the certainty of the evidence. Results. In total, 42 studies were included in this evidence mapping. Most findings were obtained from observational studies. According to the AMSTAR-2 assessment, 21 SRs scored “critically low” in terms of methodological quality, 16 SR scored “low,” and 5 SR scored “moderate.” A total of 15 diseases have been investigated for the potential association between gut microbiome alpha diversity and disease, with the Shannon index and Simpson index being the most widely studied. A total of 12 diseases were investigated for potential link between beta diversity and disease. At the phylum level, Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, and Verrucomicrobia were more researched. At the genus level, Prevotella, Coprococcus, Parabacteroides, Phascolarctobacterium, Escherichia Shigella, Alistipes, Sutteralla, Veillonella, Odoribacter, Faecalibacterium, Bacteroides, Bifidobacterium, Dialister, and Blautia were more researched. Some diseases have been found to have specific flora changes, and some diseases have been found to have common intestinal microbiological changes. Conclusion. We found varied levels of evidence for the associations between gut microbiota and neurological diseases; some gut microbiota increased the risk of neurological diseases, whereas others showed evidence of benefit that gut microbiota might be promising therapeutic targets for such diseases.

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Section: Methodological Quality Of Included Studiesmentioning

confidence: 99%

Section: Mediators Of Inflammationmentioning

confidence: 99%

The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders—An Evidence Mapping Based on Quantified Evidence

Zang

Lai

et al. 2023

Mediators of Inflammation

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“…On the contrary, the meta-analysis prepared by Wang et al [ 189 ], which evaluated the intestinal microbiota and ADHD, did not show significant differences at the phylum and family levels beyond the higher level of Blautia in patients with ADHD compared to healthy control. This microorganism plays a regulatory role in metabolic and inflammatory diseases, as well as biotransformation [ 190 ].…”

Section: The Intestinal Microbiota In Neurological and Psychiatric Di...mentioning

confidence: 92%

The Microbiota–Gut–Brain Axis in Psychiatric Disorders

Góralczyk-Bińkowska

Szmajda-Krygier

Kozłowska

2022

IJMS

171

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Modulating the gut microbiome and its influence on human health is the subject of intense research. The gut microbiota could be associated not only with gastroenterological diseases but also with psychiatric disorders. The importance of factors such as stress, mode of delivery, the role of probiotics, circadian clock system, diet, and occupational and environmental exposure in the relationship between the gut microbiota and brain function through bidirectional communication, described as “the microbiome–gut–brain axis”, is especially underlined. In this review, we discuss the link between the intestinal microbiome and the brain and host response involving different pathways between the intestinal microbiota and the nervous system (e.g., neurotransmitters, endocrine system, immunological mechanisms, or bacterial metabolites). We review the microbiota alterations and their results in the development of psychiatric disorders, including major depressive disorder (MDD), schizophrenia (SCZ), bipolar disorder (BD), autism spectrum disorder (ASD), and attention-deficit hyperactivity disorder (ADHD).

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“…Promising studies suggest the actual involvement of the microbiome in regulating brain development. Nevertheless, any disturbance that could negatively influence brain functionality could also possibly lead to a range of neurodevelopment disorders [ 14 , 55 , 56 , 57 ].…”

Section: Neurodevelopmental Disordersmentioning

confidence: 99%

Gut Microbiome and Neurodevelopmental Disorders: A Link Yet to Be Disclosed

et al. 2023

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Τhe importance of the gut microbiome and its functions has only recently been recognized and researched in greater depth. The establishment of the human gut microbiome begins in utero, forming its adult-like phenotype in the first 2–3 years of life. Several factors affect and alter the gut microbiome composition and its metabolic functions, such as early onset of breastfeeding, mode of delivery, antibiotic administration, or exposure to chemical substances, among others. Existing data support the important connection between health status and gut microbiome homeostasis. In cases when this balance is disturbed, several disorders may arise, such as inflammatory reactions that lead to atopy, eczema, or allergic asthma. The so-called gut-brain axis refers to the complex biochemical pathways between the central nervous system and the gastrointestinal system. One of the most fascinating areas of ongoing research is the broad spectrum of neurodevelopmental disorders (NDDs) and how gut health may be associated with such disorders. The prevalence of NDDs, such as autism spectrum disorder or attention deficit hyperactivity disorder, has increased over recent years. Whether gut microbiota homeostasis plays a role in these disorders is not yet fully understood. The aim of this narrative review is to provide an account of current knowledge on how gut health is linked with these disorders. We performed a literature review in order to identify and synthesize available data that highlights the potential association between NDDs and a balanced gut microbiome in terms of composition and proper function. The connection between the gut microbiome and NDDs offers promising new opportunities for future research.

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Composition of the Gut Microbiota in Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis

Cited by 25 publications

References 36 publications

The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders—An Evidence Mapping Based on Quantified Evidence

The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders—An Evidence Mapping Based on Quantified Evidence

The Microbiota–Gut–Brain Axis in Psychiatric Disorders

Gut Microbiome and Neurodevelopmental Disorders: A Link Yet to Be Disclosed

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