Compositional dependence of bioactivity of glasses in the system Na2O‐K2O‐MgO‐CaO‐B2O3‐P2O5‐SiO2

Brink, Maria; Turunen, Tia; Happonen, Risto‐Pekka; Yli‐Urpo, Antti

doi:10.1002/(sici)1097-4636(199710)37:1<114::aid-jbm14>3.3.co;2-7

Cited by 83 publications

(129 citation statements)

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“…Magnesia has often been incorporated into bioactive glasses [18][19][20][21][22][23][24][25][26][27][28][29] It is suggested that the lack of structural understanding of magnesium within glasses has lead to the many conflicting views on its contribution with respect to bioactivity. MgO has been documented as decreasing apatite formation in SBF [26] but also, on the other hand, improving the early stages of mineralization [24] and contributing to an intimate contact with living tissue.…”

Section: Introductionmentioning

confidence: 99%

Influence of magnesia on the structure and properties of bioactive glasses

Watts¹,

Hill²,

O’Donnell³

et al. 2010

Journal of Non-Crystalline Solids

253

183

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Section: Introductionmentioning

confidence: 99%

Influence of magnesia on the structure and properties of bioactive glasses

Watts¹,

Hill²,

O’Donnell³

et al. 2010

Journal of Non-Crystalline Solids

253

183

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“…Next, metal and non-metal oxides such as TiO 2 (40), ZnO (41), B 2 O 3 (42), and other materials were applied to develop nanocomposites integrated with phosphate bioglasses for the regulation of solubility, stability of the glass network, and control of the destruction levels. As in the present study, other investigations focused on the modification of bioactive glasses and found various results.…”

Section: Discussionmentioning

confidence: 99%

Bactericidal Activity of Copper Oxide Nanocomposite/Bioglass for in Vitro Clindamycin Release in Implant Infections Due to Staphylococcus aureus

Alijanian¹,

Talebian²,

Doudi³

2016

Avicenna J Med Biochem

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Background: In recent years, bioactive bioceramics such as bioglass and hydroxyapatite (HA) have been introduced as a remarkable development in the field of medicine due to their bio-adaptability, non-toxicity, and persistence, in vivo. They have many potential applications in the repair of bone defects and hence they have attracted significant interest from scholars. Objectives: The aim of this study was to synthesize inorganic matrix CuO-based bioglasses and evaluate their antibacterial activity against aerobic bacterial infections in bone implants. Methods: Nano-composite samples of silica-based bioactive glass, 60S BG with nano-powder CuO, were synthesized using the sol-gel method and then assessed with regard to their antibacterial properties against Staphylococcus aureus using well diffusion agar. The samples included BG58S (58%SiO2, 36%CaO, 6%P2O5), BG/10CuO (58%SiO2, 26%CaO, 6%P2O5, 10%CuO), and BG/20CuO (48%SiO2, 26%CaO, 6%P2O5, 20%CuO). To evaluate their bioactivity, the prepared samples of BG/20CuO, BG/10CuO, and BG58S were immersed in simulated body fluids (SBF). The surface morphology and structure of the samples before and after immersion in the SBF were characterized using scanning electron microscopy (SEM) and Fourier transform infrared (FTIR), respectively. Then, the BG/20CuO and BG/10CuO samples were loaded in clindamycin, an antibiotic widely used in the treatment of osteomyelitis, and their release profiles were studied in phosphate buffer solution. Results: It was observed that the growth inhibition zone increased through clindamycin release due to the increasing CuO percentage in the nanocomposite of bioactive glass. The bioactivity of the nanocomposite/bioglass with CuO was superior to that of bioglass alone. In this study, the BG/20CuO sample showed a sustained release of clindamycin, which is sufficient for a drug delivery system. Conclusions: Increasing the Cu nanoparticles in bioactive glass samples leads to the release of Cu 2+ , which has a positive effect on the antibacterial mechanism, as well as decreasing the cultured Staphylococcus colonies found on the bioglasses. Therefore, it seems that the nanocomposite/bioglass of CuO is a promising option for aerobic bacterial inhibitor systems in common bone implant infections.

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“…Two bioactive glasses namely 45S5 [27] and 13-93 [28] were synthesized via melt-quench technique. Batches of the pure chemical components: Fused silica (Aachener Quarz-Glas Technologie Heinrich, Aachen, Germany), CaHPO 4 (Merck, Darmstadt, Germany), CaCO 3 , Na 2 CO 3 (both AppliChem, Darmstadt, Germany) for 45S5, and additionally MgO (VWR Chemicals, Darmstadt, Germany) and K 2 CO 3 (Merck, Darmstadt, Germany) for 13-93, were homogenized and then melted at 1400 ∘ C for 2 hours in a platinum crucible.…”

Section: Methodsmentioning

confidence: 99%

Structuring of bioactive glass surfaces at the micrometer scale by direct casting intended to influence cell response

Pföss¹,

Bührig–Polaczek²,

Fischer³

et al. 2016

Biomedical Glasses

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Defect-free bioactive glass surfaces with a grooved microstructure at the low micrometer scale were achieved by a mold casting process. The process was applied to the well-known glass compositions 45S5 and 13-93. Such microstructured surfaces may exhibit especially favorable conditions for bone cell orientation and growth. The aim of the study was to assess the parameter range for a successful casting process and thus to produce samples suitable to investigate the interaction between structured surfaces and relevant cells. Viscous flow in its temperature dependence and thermal analysis were analyzed to identify a suitable process window and to design a manageable time-temperature process scheme. Counteracting effects such as formation of chill ripples, mold sticking and build-up of permanent thermal stress in the glass had to be overcome. A platinum gold alloy was chosen as mold material with the mold surface bearing the mother shape of the microstructure to be imprinted on the glass surface. First experiments studying the behavior of osteoblast-like cells, seeded on these microstructured glass surfaces revealed excellent viability and an orientation of the cells along the microgrooves. The presented results show that direct casting is a suitable process to produce defined microstructures on bioactive glass surfaces.

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Compositional dependence of bioactivity of glasses in the system Na2O‐K2O‐MgO‐CaO‐B2O3‐P2O5‐SiO2

Cited by 83 publications

References 0 publications

Influence of magnesia on the structure and properties of bioactive glasses

Influence of magnesia on the structure and properties of bioactive glasses

Bactericidal Activity of Copper Oxide Nanocomposite/Bioglass for in Vitro Clindamycin Release in Implant Infections Due to Staphylococcus aureus

Structuring of bioactive glass surfaces at the micrometer scale by direct casting intended to influence cell response

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