Field trial experiments were carried out during the June to November 2021 and 2022. Throughout both years, the trials were carried out at the same location. Obtained results showed that among the different composts made from different animal dung, goat dung compost at a rate of 100 quintal/ha was found to be superior in the case of plant height, effective tillers, earhead length, pearlmillets’ seed and straw yield. Cow-based bio-enhancers, particularly Panchagavya, enhanced plant height, effective tillers per plant, length of earhead and seed yield and straw yield compared to cow urine and Jivamrut. Fertilizer levels significantly affected plant height, effective tillers and earhead length, with the recommended dose of fertilizer outperforming 75%. Interaction effect revealed synergies between goat dung compost, Panchagavya and 100% fertilizer dose, superior plant height, earhead length and seed yield. The study highlights the potential for integrated approaches involving specific compost, cow-based bio-enhancers and fertilizer levels to optimize pearlmillet growth and yield.