Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability in animal model

Ko, Wang Sheng; Hsu, Shih-Kuang; Chyau, Charng-Cherng; Chen, Kuan Chou; Peng, Robert Y.

doi:10.1016/j.fitote.2009.06.018

Cited by 20 publications

(14 citation statements)

References 28 publications

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“…It has been reported that the hepatoprotection of OSM against CCl 4 resulted in decreased serum AST and ALT values. Concurrently, increased antioxidative capabilities by OSM supplementation were also observed [29]. Based on our results, there are not (p>0.05) differences on antioxidant enzymatic activities in livers among groups, except GPx activity; and meanwhile, OSM supplementation did not powerfully enhance those enzymatic activities in our study.…”

Section: Discussionsupporting

confidence: 60%

Preventive Effects of Ophiocordyceps sinensis Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Chou¹,

Lin²,

Wu³

et al. 2017

JFNR

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Dyslipidemia is regarded as one of risk factors related to cardiovascular disease and hepatosteatosis widely. Due to westernized diet habits and lifestyle changes, there is a high prevalence of those lipid-dysregulated diseases, i.e. fatty liver, hyperlipidemia, diabetes etc. However, the liver holds the lipid homeostasis so hepatoprotective nutraceuticals against high-fat diet (HFD) induced dyslipidemia may be potential for a public demand. This study demonstrated that OSM containing 10% polysaccharides and 0.25% adenosine can decrease (p<0.05) serum and liver triglyceride (TG) contents, and meanwhile, increased (p<0.05) fecal cholesterol (TC) levels in HFD fed mice. Moreover, Ophiocordyceps sinensis mycelium (OSM) also decreased (p<0.05) serum low-density lipoprotein cholesterol (LDLC) levels and the atherosclerosis index (LDLC/high-density lipoprotein cholesterol (HDLC)) in HFD fed mice. Regarding the liver damage, OSM supplementation attenuated serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values, and liver tumor necrosis factor-α (TNF-α) levels in HFD fed mice. Taken together, OSM showed an ameliorative effect of the hepatosteatosis development and lipid-dysregulated-related diseases in a HFD habit.

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Section: Discussionsupporting

confidence: 60%

Preventive Effects of Ophiocordyceps sinensis Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Chou¹,

Lin²,

Wu³

et al. 2017

JFNR

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“…Similarly, Chen et al reported that the liver antioxidative capacities were decreased in TAA‐intoxication (Table ) while the hepatic lipid accumulation in TAA‐injected rats was increased . Correspondingly, the hepatoprotection of OSM against CCl 4 resulted in decreased serum AST and ALT values, concurrently, increased antioxidative capabilities via OSM supplementation were also observed . Regarding to effects of OSM on exercised rats, Ophiocordyceps sinensis improved an exercise endurance capacity by activating not only the skeletal muscle metabolic regulators but also a coordinated antioxidative response .…”

Section: Resultsmentioning

confidence: 87%

Preventive effects of Ophiocordyceps sinensis mycelium on the liver fibrosis induced by thioacetamide

Tseng

Chou

et al. 2017

Environmental Toxicology

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Thioacetamide (TAA), usually used as a fungicide to control the decay of citrus products, itself is not toxic to the liver, but its intermediates are able to increase oxidative stress in livers and further cause fibrosis. Ophiocordyceps sinensis mycelium (OSM) which contains 10% polysaccharides and 0.25% adenosine decreased (P < 0.05) the lipid accumulation and increased (P < 0.05) antioxidative capacity in livers of thioacetamide (TAA) injected rats. Meanwhile, the increased (P < 0.05) liver sizes, serum alanine transaminase (AST) and aspartate transaminase (ALT) values in thioacetamide (TAA)-injected rats were ameliorated (P < 0.05) by OSM supplementation. Moreover, the levels of proinflammatory cytokines, such as the tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), were also reduced (P < 0.05). The fibrosis phenomena in pathological (Masson's trichrome and H&E stainings) and immunohistochemical [α-smooth actin (αSMA) and CD86/ED1] observations in TAA-treated rats were reduced (P < 0.05) by OSM cotreatment. The protective effect of OSM against TAA-induced liver inflammation/fibrosis may be via downregulations (P < 0.05) of TGF-β pathways and NFκB which further influenced (P < 0.05) the expressions of fibrotic and inflammatory genes (i. e., αSMA, Col1α, COX2). Therefore, OSM shows preventive effects on the development of TAA-induced hepatic fibrosis.

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“…Nevertheless, chemical toxins (including acetaminophen, carbon tetrachloride, thioacetamide, ethanol, D-galactosamine, diethylnitrosamine and dimethylnitrosamine) are often used as the model substances causing experimental hepatocyte injury under both in vivo and in vitro conditions [10,[34][35][36][37][38][39][40][41][42][43][44][45][46][47].…”

Section: Main Hepatotoxic Agents Used In Hepatoprotective Studiesmentioning

confidence: 99%

Hepatoprotective Effects of Mushrooms

et al. 2013

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Abstract:The particular characteristics of growth and development of mushrooms in nature result in the accumulation of a variety of secondary metabolites such as phenolic compounds, terpenes and steroids and essential cell wall components such as polysaccharides, β-glucans and proteins, several of them with biological activities. The present article outlines and discusses the available information about the protective effects of mushroom extracts against liver damage induced by exogenous compounds. Among mushrooms, Ganoderma lucidum is indubitably the most widely studied species. In this review, however, emphasis was given to studies using other mushrooms, especially those presenting efforts of attributing hepatoprotective activities to specific chemical components usually present in the mushroom extracts.

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Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability in animal model

Cited by 20 publications

References 28 publications

Preventive Effects of <i>Ophiocordyceps </i><i>s</i><i>inensis </i>Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Preventive Effects of <i>Ophiocordyceps </i><i>s</i><i>inensis </i>Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Preventive effects of Ophiocordyceps sinensis mycelium on the liver fibrosis induced by thioacetamide

Hepatoprotective Effects of Mushrooms

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