Compound K Inhibits Interleukin-1β-induced Expression of Inflammatory Mediators and Matrix Metalloproteinases by Inhibiting Mitogen-activated Protein Kinase Activation in Chondrocytes

Park, Eun Hye; Kim, Ji Soo; Lee, Jeong Seok; Lee, Yun Jong; Song, Yeong Wook

doi:10.4078/jrd.2018.25.3.188

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…Several risk factors, including elderly women, high body mass index (BMI), and joint injuries, have been identified as associated with OA (Silverwood, 2015;Park, 2018). Decreased muscle mass, thinning of the cartilage layer, and thickening of the subchondral often occur in the elderly.…”

Section: Introductionmentioning

confidence: 99%

The relationship of body mass index and T score in healthy and knee osteoarthritis women

Achmad,

Suharjono,

Soeroso

et al. 2023

Pharm Educ

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Background: Osteoarthritis (OA) is a chronic, degenerative, slowly progressive disease common in women with multiple aetiology. Osteoarthritis occurs simultaneously with the reduction in bone mineral density (BMD)while a high bone mass index (BMI) value is one of the risk factors for OA. Objective: The purpose of this study was to determine the effect of BMI and BMD in healthy and knee OA women. Method: The study was conducted in an orthopaedic outpatient clinic in 2021. This is a quantitative descriptive study with accidental cross-sectional samplings. The Mann-Whitney test was used to analyse the data. Result: Subjects included in the inclusion criteria obtained 74 OA and 49 control groups. The largest subjects in the OA group were aged 56-65 years old (32, 43.24%), obese (51, 68.92%), and post-menopause (49, 66.22%). At the same time, the T score category was normal (14, 18.91%), osteopenia (22, 29.73%), and osteoporosis (38, 51.35%). Statistical analysis found a significant relationship between BMI and BMD (p = 0.002, p = 0.001) in controls and OA groups. Conclusion: Disorders of BMI and BMD are indicators of risk for OA. High BMI and low BMD values occur in women with knee OA. There is a relationship between BMI and BMD in healthy and knee OA women.

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Section: Introductionmentioning

confidence: 99%

The relationship of body mass index and T score in healthy and knee osteoarthritis women

Achmad,

Suharjono,

Soeroso

et al. 2023

Pharm Educ

View full text Add to dashboard Cite

show abstract

“…In adult cartilage, a balance exists between the synthesis and degradation of the cartilaginous extracellular matrix. However, inflammation can cause an imbalance between expression of anabolic [aggrecan (ACAN) and collagen type II (COL2)] and catabolic [matrix metalloproteinases (MMPs)] factors in chondrocyte tissue (8)(9)(10). A severe imbalance between anabolic and catabolic chondrocyte factors leads to progressive degradation of the cartilage matrix (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Blocking TNFα attenuates progressive cartilage matrix degradation in inflammatory arthritis

Park

Lee

et al. 2021

Exp Ther Med

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Because damage to hyaline cartilage is irreversible, relieving progressive cartilage destruction is an important therapeutic approach for inflammatory arthritis. In the present study, human hyaline chondrocytes were isolated from total knee replacements of 15 patients with osteoarthritis (OA) and three with rheumatoid arthritis (RA). Synovial fluid of OA (n=25) and RA (n=34) were collected to measure tumor necrosis factor α (TNFα) using ELISA. Consistent with previous studies, the synovial fluid exhibited high TNFα levels and hyaline cartilage was severely destroyed in patients with RA. TNFα-treated chondrocytes were used as model for inflammatory arthritis. TNFα did not influence proliferation or extracellular matrix expression in chondrocytes, but induced matrix metalloproteinase (MMP)1, 3 and 13 expression levels in chondrocytes, which was accompanied by activation of nuclear factor-κB signaling. During chondrogenic differentiation, TNFα attenuated mRNA expression levels of anabolic factors (collagen type 2 and aggrecan) and enhanced mRNA expression of catabolic factors (MMP1, MMP3 and MMP13) in chondrocytes. Moreover, anti-TNFα agents (Golimumab) inhibited the TNFα-induced metabolic shift in chondrocytes and chondrogenic differentiation. The present study revealed a mechanism by which TNFα may induce metabolic shift in chondrocytes, leading to progressive chondrocyte destruction.

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“…Although the etiology of OA is not fully understood, environmental factors likely play an important role in the development of OA in genetically susceptible individuals. Many risk factors including older age, female gender, higher body mass index, and joint injury have been identi-fied to be associated with OA [3,4]. OA is more common in individuals with high bone mineral density (BMD), and observational studies have found that higher BMD is associated with an increased risk of OA [5,6].…”

Section: Introductionmentioning

confidence: 99%

Causal Association between Bone Mineral Density and Osteoarthritis: A Mendelian Randomization Study

Song

Lee

2019

J Rheum Dis

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Objective. To examine whether bone mineral density (BMD) is causally associated with osteoarthritis (OA). Methods. We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighting (IVW), weighted median, and MR-Egger regression methods. We used publicly available summary statistics datasets of a genome-wide association study (GWAS) on femur neck (FN) BMD of individuals of European ancestry as the exposure and a GWAS for non-cancer illness code self-reported: OA from the individuals included in the UK Biobank as the outcome. Results. We selected 21 independent single-nucleotide polymorphisms with genome-wide significance (p＜5.00E-08) from GWAS on FN BMD as the instrumental variables. The IVW method (beta=0.010, standard error [SE]=0.003, p=0.002) and the weighted median approach (beta=0.011, SE=0.004, p=0.006) yielded evidence of a causal association between FN BMD and OA. However, the MR-Egger analysis showed no causal association between FN BMD and OA (beta=0.005, SE=0.017, p=0.753). Since MR-Egger regression suffers from a lack of power and a susceptibility to weak instrument bias, the MR analysis results may support a causal association between FN BMD and OA. Conclusion. The results of MR analysis by IVW and weighted median, but not MR-Egger regression indicate that FN BMD is likely to be causally associated with an increased risk of OA incidence The current findings may provide an opportunity to elucidate the underlying mechanisms of the effects of BMD on the OA incidence.

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Compound K Inhibits Interleukin-1β-induced Expression of Inflammatory Mediators and Matrix Metalloproteinases by Inhibiting Mitogen-activated Protein Kinase Activation in Chondrocytes

Cited by 4 publications

References 39 publications

The relationship of body mass index and T score in healthy and knee osteoarthritis women

The relationship of body mass index and T score in healthy and knee osteoarthritis women

Blocking TNFα attenuates progressive cartilage matrix degradation in inflammatory arthritis

Causal Association between Bone Mineral Density and Osteoarthritis: A Mendelian Randomization Study

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