2019
DOI: 10.3892/mmr.2019.10261
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Comprehensive analysis of differentially expressed profiles of non‑coding RNAs in peripheral blood and ceRNA regulatory networks in non‑syndromic orofacial clefts

Abstract: Non-syndromic orofacial clefts (NSOC), which include cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO), are common congenital birth defects in humans. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) and microRNAs (miRNAs or miRs) play important roles in NSOC; however, the potential regulatory associations between them remain largely unknown. In this study, we performed next-generation RNA sequencing (RNA-seq) to identify transcriptome profiles, including mRNAs, lncRN… Show more

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Cited by 7 publications
(10 citation statements)
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“…Although recent advancements will prove useful for understanding OFC etiologies, miRNAs appear to have more complicated mechanisms of regulation. These include the formation of competitive endogenous networks with long noncoding RNAs (lncRNA) (Gao et al, 2019), as well as the ability to bind gene promoters and activate their expression through a process called RNA activation (Ramchandran & Chaluvally‐Raghavan, 2017). As in the past decade of research, it is expected that the near future will bring informative advances in our understanding of OFC etiology for both miRNAs and epigenetic processes.…”
Section: Resultsmentioning
confidence: 99%
“…Although recent advancements will prove useful for understanding OFC etiologies, miRNAs appear to have more complicated mechanisms of regulation. These include the formation of competitive endogenous networks with long noncoding RNAs (lncRNA) (Gao et al, 2019), as well as the ability to bind gene promoters and activate their expression through a process called RNA activation (Ramchandran & Chaluvally‐Raghavan, 2017). As in the past decade of research, it is expected that the near future will bring informative advances in our understanding of OFC etiology for both miRNAs and epigenetic processes.…”
Section: Resultsmentioning
confidence: 99%
“…By contrast, in cultured fibroblasts isolated from non‐syndromic CLP individuals, has‐miR‐505‐3p is significantly downregulated 105 . Previous studies suggest that miRs detected in blood and saliva would be a biomarker of non‐syndromic CL/P 106‐108 . Thus, the miRs identified might be potentially altered by genetic mutations in the non‐coding regions as well as by environmental factors.…”
Section: Pathological Mechanisms Of Cleft Palatementioning
confidence: 94%
“…101 105 Previous studies suggest that miRs detected in blood and saliva would be a biomarker of non-syndromic CL/P. [106][107][108] Thus, the miRs identified might be potentially altered by genetic mutations in the non-coding regions as well as by environmental factors.…”
Section: Micrornas Associated With Cleft Lip And/or Cleft Palatementioning
confidence: 99%
“…Moreover, dysregulation of lncRNAs could be related to the progression of many disorders ( Peng et al, 2017 ; Chi et al, 2019 ; Ye et al, 2020a ). They have also been shown to participate in the development of lip and palate and the pathogenesis of related diseases ( Gerrard et al, 2016 ; Gao et al, 2019 ; Shu et al, 2019 ). There have been a few of reports on the role of lncRNAs in CLP ( Uslu et al, 2014 ; Gao et al, 2017 ; Yun et al, 2019 ), let alone NSCLP.…”
Section: Introductionmentioning
confidence: 99%
“…There have been a few of reports on the role of lncRNAs in CLP ( Uslu et al, 2014 ; Gao et al, 2017 ; Yun et al, 2019 ), let alone NSCLP. RNA sequencing to identify transcriptome profiles including mRNAs, lncRNAs, and microRNAs (miRNAs) in NSCLP was performed in 2019 for the first time, and the potential role of lncRNAs in NSCLP has been suggested ( Gao et al, 2019 ). So far, only several lncRNAs have been identified to be associated with NSCLP in previous studies, including lncRNA RP11-462G12.2, CCDC26 lncRNA, and a long non-coding interval at 8q24 ( Uslu et al, 2014 ; Wu et al, 2019 ; Yun et al, 2019 ).…”
Section: Introductionmentioning
confidence: 99%