Comprehensive analysis of the prognosis for chromobox family in gastric cancer

Kang, Lin; Zhu, Jinfeng; Hu, Cegui; Bu, Fanqin; Luo, Chen; Zhu, Xiaojian; Zhu, Zhengming

doi:10.21037/jgo-20-208

Cited by 13 publications

(14 citation statements)

References 69 publications

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“…In previous studies, overexpression of CBX1 has been found in many cancers such as hepatocellular carcinoma ( 33 , 34 ), gastric cancer ( 35 , 36 ), colorectal cancer ( 37 ), and pituitary cancer ( 38 ). In HCC, CBX1 functions as an oncogene by interacting with the transcription factor HMGA2 to activate the Wnt/β-catenin signaling pathway ( 33 ).…”

Section: Discussionmentioning

confidence: 95%

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Comprehensive Analysis of the Expression and Prognosis Value of Chromobox Family Members in Clear Cell Renal Cell Carcinoma

Zhu

et al. 2021

Front. Oncol.

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Clear cell renal cell carcinoma (ccRCC) accounts for 80% of all renal cancers and has a poor prognosis. Chromobox (CBX) family protein expression has been reported in a variety of human malignancies, but the roles of CBXs in ccRCC remain unclear. In this study, by using ONCOMINE, UALCAN, GEPIA, Kaplan-Meier Plotter, cBioPortal, and TIMER, we found the transcriptional levels of CBX3 and CBX4 in ccRCC tissues were significantly higher than those in normal kidney tissues, whereas the transcriptional levels of CBX1, CBX5, CBX6, and CBX7 were significantly reduced in ccRCC tissues. The promoters of CBX2, CBX3, CBX4, CBX5, CBX6, CBX7, and CBX8 were hypermethylated, whereas the CBX1 promoter was hypomethylated in ccRCC. The expression of CBX1, CBX3, CBX4, CBX5, CBX6, and CBX7 was significantly associated with clinicopathological parameters in ccRCC patients. ccRCC patients with high expression levels of CBX3, CBX4, and CBX8 and low expression levels of CBX1, CBX5, CBX6, and CBX7 showed a strong association with poor overall survival. Genetic alterations in CBXs were correlated with poor overall survival and disease-free survival in patients with ccRCC. Moreover, we found significant associations between the expression of CBXs and infiltration of immune cells (B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells). Our results provide novel insights into the development of CBX-based biomarkers and therapeutic targets for ccRCC.

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Section: Discussionmentioning

confidence: 95%

“…Overexpression of CBX3 has also been observed in many malignancies such as lung cancer ( 43 , 44 ), gastric cancer ( 36 , 45 ), and tongue squamous cell carcinoma ( 46 , 47 ). High CBX3 targets CDKN1A to promote the proliferation of U87 cells and predicts poor recurrence-free survival and OS in glioma patients ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of the Expression and Prognosis Value of Chromobox Family Members in Clear Cell Renal Cell Carcinoma

Zhu

et al. 2021

Front. Oncol.

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“…However, Kaplan–Meier plotter showed that high CBX7 mRNA expression was associated with poor OS. One explanation for this finding is that although CBX7 mRNA expression is low in cancer tissues, CBX7 protein expression is significantly elevated in tumor tissues 51 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the prognostic value of CBXs in gastric cancer patients

Liu

Wang

et al. 2021

Sci Rep

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Chromobox (CBX) proteins were suggested to exert epigenetic regulatory and transcriptionally repressing effects on target genes and might play key roles in the carcinogenesis of a variety of carcinomas. Nevertheless, the functions and prognostic significance of CBXs in gastric cancer (GC) remain unclear. The current study investigated the roles of CBXs in the prognosis of GC using the Oncomine, The Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, The Cancer Genome Atlas (TCGA), and cBioPortal databases. CBX1/2/3/4/5 were significantly upregulated in GC tissues compared with normal tissues, and CBX7 was downregulated. Multivariate analysis showed that high mRNA expression levels of CBX3/8 were independent prognostic factors for prolonged OS in GC patients. In addition, the genetic mutation rate of CBXs was 37% in GC patients, and genetic alterations in CBXs showed no association with OS or disease-free survival (DFS) in GC patients. These results indicated that CBX3/8 can be prognostic biomarkers for the survival of GC patients.

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“…Similarly, CBX8 plays a signi cant role in lymphoma, breast carcinoma, esophageal squamous cell carcinoma, esophageal cancer, and other human cancers [41]. Studies carried out by Yuan et al showed that upregulated CBX8 was associated with the progression of the stages in muscle-invasive bladder cancer tissues by repressing the p53 pathway [42].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of the Clinical Significance and Prognostic Value of the CBX Family in Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC)

Zhou¹,

Ma²,

Wu³

et al. 2021

Preprint

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Background: Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) is the second most common type of cancer among gynecologic malignancies worldwide. Chromobox (CBX) family proteins are associated with the regulation of tumorigenesis, metastasis, and evolution of various cancers.Methods: The clinical features, expression levels, and prognostic value of CBXs in CESC were analyzed through several databases, including ONCOMINE, GEPIA, HPA, UALCAN, cBioPortal, Kaplan-Meier plotter, and Metascape.Results: We concluded that the expression level of CBX2/4/8 was upregulated, while the expression level of CBX6/7 was downregulated in CESC specimens. Immune infiltration analysis revealed that CBX1/2/3/4/5/6/8 proteins were downregulated in normal cervical tissues, and upregulated in CESC specimens. In contrast, CBX7 protein expression was significantly higher in normal adjacent cervical tissues and was not detected in CESC tissues. CBX1/3/6 mRNA expression was significantly correlated with the pathological stage of CESC. Prognostic analysis showed that patients with high CBX7 levels of CESC had a favorable prognosis.Conclusions: Our study indicated that CBX7 could be an attractive biomarker for the prognosis of CESC.

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Comprehensive analysis of the prognosis for chromobox family in gastric cancer

Cited by 13 publications

References 69 publications

Comprehensive Analysis of the Expression and Prognosis Value of Chromobox Family Members in Clear Cell Renal Cell Carcinoma

Comprehensive Analysis of the Expression and Prognosis Value of Chromobox Family Members in Clear Cell Renal Cell Carcinoma

Evaluation of the prognostic value of CBXs in gastric cancer patients

Comprehensive Analysis of the Clinical Significance and Prognostic Value of the CBX Family in Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC)

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