Comprehensive analysis suggests simple processes underlying EEG/ERP – Demonstration with the go/no-go paradigm in ADHD

Shahaf, Goded; Fisher, Tali; Aharon‐Peretz, Judith; Pratt, Hillel

doi:10.1016/j.jneumeth.2014.10.016

Cited by 25 publications

(46 citation statements)

References 22 publications

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“…We follow in this regard a known methodology, which scans the raw EEG data for patterns, which were identified in the averaged ERP signal (16). It should be stressed that while in the averaged ERP sample our marker is time locked to the stimulus (13, 14), we noted that the marker onset is much more flexible at the single-trial level. Such large temporal variability (in the scale of many hundreds of milliseconds) is known in the literature and is larger for the low frequency EEG activity.…”

Section: Introductionmentioning

confidence: 70%

“…The EEG data were recorded from the NeuroSky MindWave single-channel system (NeuroSky Inc., San Jose, CA, USA—CE authorized), with one frontal electrode (~Fpz) and one reference electrode on the earlobe, at a sampling rate of 512 Hz. In previous works, we noted that our template marker could be extracted from any sagittal or parasagittal electrode in the central and frontal regions, if the reference is periauricular (14). As a setup of dry electrodes, which sample below the hairline is easier to use, we chose the Fpz frontal location and the earlobe reference location.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The computation is based on template matching (14), a technique that uses a basic template, which is compared with the sampled signal. In this case, the template was a 1,500 ms attention-associated averaged ERP delta bandpass activity (14), which was matched with a moving window of the same size in the sampled signal. The matching was performed as follows: (i) the 1-min sample was divided into segments of 10 s; (ii) each segment was filtered in the delta bandpass (1–4 Hz); (iii) the data points in the filtered segment were normalized to the [−1, +1] range, where −1 denotes the most negative and +1 the most positive voltage deflection within the filtered segment; (iv) the process of filtering and normalization to [−1, +1] was also performed for the 1,500 averaged Delta ERP wave, shown in Figure 1 top inset, to generate the template [taken from Ref.…”

Section: Methodsmentioning

confidence: 99%

“…Our work shows that attention processes can be efficiently monitored over a wide frontocentral area, using prefrontal electrodes (13, 14). We developed a method to monitor prefrontal activity using a simple and minimal setup of two electrodes.…”

Section: Introductionmentioning

confidence: 98%

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A Pilot Study of Possible Easy-to-Use Electrophysiological Index for Early Detection of Antidepressive Treatment Non-Response

Shahaf¹,

Yariv

Bloch

et al. 2017

Front. Psychiatry

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IntroductionThe evaluation of response to pharmacological treatment in MDD requires 4–8 weeks. Therefore, the ability to predict response, and especially lack of response to treatment, as early as possible after treatment onset or change, is of prime significance. Many studies have demonstrated significant results regarding the ability to use EEG and ERP markers, including attention-associated markers such as P300, for early prediction of response to treatment. But these markers are derived from long EEG/ERP samples, often from multiple channels, which render them impractical for frequent sampling.Methods and resultsWe developed a new electrophysiological attention-associated marker from a single channel (two electrodes), using 1-min samples with auditory oddball stimuli. This work presents an initial evaluation of the ability to use this marker’s dynamics between repetitive measures for early (<2 weeks) differentiation between responders and non-responders to antidepressive treatment, in 26 patients with various levels of depression and heterogeneous treatment interventions. The slope of change in the marker between early consecutive samples was negative in the non-responders, but not in the responders. This differentiation was stronger for patients suffering from severe depression (p < 0.001).ConclusionThis pilot study supports the feasibility of the EEG marker for early recognition of treatment-resistant depression. If verified in large-scale prospective studies, it can contribute to research and clinical work.

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Section: Introductionmentioning

confidence: 70%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 3 more Smart Citations

A Pilot Study of Possible Easy-to-Use Electrophysiological Index for Early Detection of Antidepressive Treatment Non-Response

Shahaf¹,

Yariv

Bloch

et al. 2017

Front. Psychiatry

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Methylphenidate promotes the interaction between motor cortex facilitation and attention in healthy adults: A combined study using event‐related potentials and transcranial magnetic stimulation

et al. 2018

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ObjectiveThis study investigated simultaneously the impact of methylphenidate (MPH) on the interaction of inhibitory and facilitative pathways in regions processing motor and cognitive functions.MethodNeural markers of attention and response control (event‐related potentials) and motor cortical excitability (transcranial magnetic stimulation) and their pharmacological modulation by MPH were measured simultaneously in a sample of healthy adults (n = 31) performing a cued choice reaction test.ResultsMethylphenidate modulated attentional gating and response preparation processes (increased contingent negative variation) and response inhibition (increased nogo P3). N1, cue‐ and go‐P3 were not affected by MPH. Motor cortex facilitation, measured with long‐interval cortical facilitation, was increased under MPH in the nogo condition and was positively correlated with the P3 amplitude.ConclusionMethylphenidate seems particularly to enhance response preparation processes. The MPH‐induced increased motor cortex facilitation during inhibitory task demands was accompanied by increased terminal response inhibition control, probably as a compensatory process.

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Markers of too little effort or too much alertness during neuropsychological assessment: Demonstration with perioperative changes

Baron‐Shahaf,

Shahaf

2024

Brain and Behavior

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ObjectiveCognitive assessment is based on performance in different tests. However, this performance might be hindered by lack of effective effort on the one hand, and by too much stress on the other hand. Despite their known impact, there are currently no effective tools for measuring cognitive effort or stress effect during cognitive assessment. We developed real‐time electrophysiological markers for cognitive effort and for stress effect, which could be used during cognitive assessment.MethodsWe assessed these markers during the use of the Montreal Cognitive Assessment (MoCA) before and after cardiac surgery, which is known to involve cognitive decline in up to 30%–50% of elderly patients.ResultsThe major findings of the study, for the largest group of patients, with preoperative MoCA in the intermediate range, were that the decline is significantly associated (1) with higher preoperative cognitive effort and (2) with higher postoperative stress effect during the test.ConclusionsThese findings, as well as preliminary additional ones, suggest a potential importance for monitoring cognitive effort and stress effect during assessment in general, and specifically during perioperative assessment.SignificanceEasy‐to‐use markers could improve the efficacy of cognitive assessment and direct treatment generally, and specifically for perioperative decline.

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Comprehensive analysis suggests simple processes underlying EEG/ERP – Demonstration with the go/no-go paradigm in ADHD

Cited by 25 publications

References 22 publications

A Pilot Study of Possible Easy-to-Use Electrophysiological Index for Early Detection of Antidepressive Treatment Non-Response

A Pilot Study of Possible Easy-to-Use Electrophysiological Index for Early Detection of Antidepressive Treatment Non-Response

Methylphenidate promotes the interaction between motor cortex facilitation and attention in healthy adults: A combined study using event‐related potentials and transcranial magnetic stimulation

Markers of too little effort or too much alertness during neuropsychological assessment: Demonstration with perioperative changes

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