The land use change (LUC) and urbanization caused by human activities have markedly increased the occurrence of landslides, presenting significant challenges in accurately predicting landslide susceptibility despite decades of model advancements. This study, focusing on the Li River Valley (LRV) within the Yongding District, China, employs two common models, namely an analytic hierarchy process–comprehensive index (AHP-CI) model and a logistic regression (LR) model to assess landslide susceptibility (LS). The AHP-CI model is empirically based, with the advantage of being constructible and applicable at various scales without a dataset, though it remains highly subjective. The LR model is a statistical model that requires a training set. The two models represent heuristic and statistical approaches, respectively, to assessing LS. Meanwhile, the basic geological and environmental conditions are considered in the AHP-CI model, while the LR model accounts for the conditions of LUC and urbanization. The results of the multicollinearity diagnostics reflect the rationality of the predisposing factor selection (1.131 < VIF < 4.441). The findings reveal that the AHP-CI model underperforms in LUC and urbanization conditions (AUROC = 0.645, 0.628, and 0.667 for different validation datasets). However, when all the time-varying human activity predisposing factors are considered, the LR model (AUROC = 0.852) performs significantly better under the conditions of solely considering 2010 (AUROC = 0.744) and 2020 (AUROC = 0.810). The CA–Markov model was employed to project the future land use for the short-term (2025), mid-term (2030), and long-term (2040) planning periods. Based on these projections, maps of future LS were created. Importantly, this paper discussed the relationships between landslide management and regional sustainable development under the framework of the UN SDGs, which are relevant to Goal 1, Goal 11, Goal 13, and Goal 15. Finally, this study highlights the importance of integrating strategic land planning, reforestation efforts, and a thorough assessment of human impact predisposing factors with SDG-aligned LS predictions, advocating for a comprehensive, multi-stakeholder strategy to promote sustainable landslide mitigation.