Comprehensive bioinformatic analysis of MMP1 in hepatocellular carcinoma and establishment of relevant prognostic model

Dai, Lei; Mugaanyi, Joseph; Cai, Xingchen; Dong, Mingjun; Lu, Caide; Lu, Changjiang

doi:10.1038/s41598-022-17954-x

Cited by 12 publications

(10 citation statements)

References 71 publications

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“…Combined with survival analysis and ROC curve analysis, we concluded that MMP1 expression was related to the prognosis of OS or DFS in CESC, GBM, HNSC, OV, and PAAD, and had high diagnostic value. In LIHC, MMP1 expression was associated with OS and DFS outcomes, which is consistent with a previous study ( 20 ). However, ROC curves showed that MMP1 didn’t have a high predictive accuracy in LIHC, and thus the prognostic role of MMP1 in HCC remained of concern.…”

Section: Discussionsupporting

confidence: 92%

A pan-cancer analysis of the prognostic and immunological roles of matrix metalloprotease-1 (MMP1) in human tumors

et al. 2023

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ObjectiveCancer remains the leading killer of human health worldwide. It has been shown that matrix metalloproteinase-1(MMP1) is related to poor prognosis in cancers such as BRCA, CESC and COAD. However, systematic pan-cancer analysis about the prognostic and immunological roles of MMP1 has not been explored. Here, the purpose of this study was to investigate the prognostic and immunological roles of MMP1 in pan-cancer and confirm cancer-promoting effect in pancreatic cancer.MethodsIn our study, bioinformatics were first used to analyze data from multiple databases. Then, several bioinformatics tools were utilized to investigate the role of MMP1 in 33 tumor types. Finally, molecular biology experiments were carried out to prove the cancer-promoting effect of MMP1 in pancreatic cancer.ResultsMMP1 expression was higher in tumor tissues than in control tissues in most tumor types. High expression of MMP1 was associated with poor overall survival (OS) and disease-free survival (DFS) in some tumor types. Further analysis of MMP1 gene mutation data showed that MMP1 mutations significantly influenced the prognosis of STAD. In addition, MMP1 expression was closely related to cancer-associated fibroblast (CAFs) infiltration in a variety of cancers and played an important role on immune infiltration score, tumor mutational burden (TMB) and microsatellite instability (MSI). Gene Ontology enrichment analysis indicated that these 20 genes were mainly related to extracellular structure organization/extracellular matrix organization/extracellular matrix disassembly/collagen metabolic process in the enriched biological processes. Finally, molecular biology experiments confirmed the cancer-promoting effect of MMP1 in pancreatic cancer.ConclusionsOur pan-cancer analysis comprehensively proved that MMP1 expression is related with clinical prognosis and tumor immune infiltration, and MMP1 can become a prognostic and immunological biomarker.

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Section: Discussionsupporting

confidence: 92%

A pan-cancer analysis of the prognostic and immunological roles of matrix metalloprotease-1 (MMP1) in human tumors

et al. 2023

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“…MMP-1 was expressed in many different malignant tumors higher than in corresponding normal tissues. 24 The transcription of MMP-1 is activated by AP-1, 23 including c-fos and c-jun . In hepatocellular carcinoma (HCC) patients, MMP-1 was upregulated and related to poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Human antigen R knockdown attenuates the invasive activity of oral cancer cells through inactivation of matrix metalloproteinase-1 gene expression

Kakuguchi

Kitamura

Takahashi

et al. 2024

Journal of Dental Sciences

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“…MMP1 is upregulated in patients with HCC and is associated with a poor prognosis. [42] Pharmacological inhibition and gene silencing of TRPA1 downregulates MMP1 production in osteoarthritis, [43] whereas activation of TRPV1 increases the expression of MMP1 . [44] However, in the present study, specific levels of TRPA1 and TRPV1 were not detected in HCC tissues.…”

Section: Discussionmentioning

confidence: 99%

Identification of molecular subtypes and prognostic signatures based on transient receptor potential channel-related genes to predict the prognostic risk of hepatocellular carcinoma: A review

Wu¹,

Cai²,

Liu³

et al. 2023

Medicine

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Abnormal transient receptor potential (TRP) channel function interferes with intracellular calcium-based signaling and causes malignant phenotypes. However, the effects of TRP channel-related genes on hepatocellular carcinoma (HCC) remain unclear. This study aimed to identify HCC molecular subtypes and prognostic signatures based on TRP channel-related genes to predict prognostic risks. Unsupervised hierarchical clustering was applied to identify HCC molecular subtypes using the expression data of TRP channel-related genes. This was followed by a comparison of the clinical and immune microenvironment characteristics between the resulting subtypes. After screening for differentially expressed genes among subtypes, prognostic signatures were identified to construct risk score-based prognostic and nomogram models and predict HCC survival. Finally, tumor drug sensitivities were predicted and compared between the risk groups. Sixteen TRP channel-related genes that were differentially expressed between HCC and non-tumorous tissues were used to identify 2 subtypes. Cluster 1 had higher TRP scores, better survival status, and lower levels of clinical malignancy. Immune-related analyses also revealed higher infiltration of M1 macrophages and higher immune and stromal scores in Cluster 1 than in Cluster 2. After screening differentially expressed genes between subtypes, 6 prognostic signatures were identified to construct prognostic and nomogram models. The potential of these models to assess the prognostic risk of HCC was further validated. Furthermore, Cluster 1 was more distributed in the low-risk group, with higher drug sensitivities. Two HCC subtypes were identified, of which Cluster 1 was associated with a favorable prognosis. Prognostic signatures related to TRP channel genes and molecular subtypes can be used to predict HCC risk.Abbreviations: AUCs = area under the curve, DEGs = differentially expressed genes, HCC = hepatocellular carcinoma, HRP = high-risk prognosis, IC50 = 50% inhibitory concentration, KM = Kaplan-Meier, LRP = low-risk prognosis, MMP = matrix metalloproteinase, TCGA = The Cancer Genome Atlas, TRP = transient receptor potential.

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Comprehensive bioinformatic analysis of MMP1 in hepatocellular carcinoma and establishment of relevant prognostic model

Cited by 12 publications

References 71 publications

A pan-cancer analysis of the prognostic and immunological roles of matrix metalloprotease-1 (MMP1) in human tumors

A pan-cancer analysis of the prognostic and immunological roles of matrix metalloprotease-1 (MMP1) in human tumors

Human antigen R knockdown attenuates the invasive activity of oral cancer cells through inactivation of matrix metalloproteinase-1 gene expression

Identification of molecular subtypes and prognostic signatures based on transient receptor potential channel-related genes to predict the prognostic risk of hepatocellular carcinoma: A review

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