Comprehensive diagnosis of parasites in sheep kept under different zootechnical management in a region temperate in Mexico

Acevedo-Ramírez, P.M.C.; García-Soria, A. L.; Ullóa-Arvízu, Raúl; Mendoza, Irene Cruz; Quiróz-Romero, H.

doi:10.1007/s11259-021-09863-7

Cited by 1 publication

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“…The main strategy employed for GIN control in sheep and goats has been carried out using anthelmintic drugs. However, the excessive use of these drugs results in a high economic cost over the world and usually induces the development of resistance in GIN to most anthelmintic drugs of the same chemical group [ 6 , 7 , 8 , 9 ]. Haemonchus contortus is a parasitic nematode (Order: Strongylida) belonging to the Trichostrongylidae family.…”

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confidence: 99%

In Vitro Anthelmintic Activity of a Hydroalcoholic Extract from Guazuma ulmifolia Leaves against Haemonchus contortus

et al. 2022

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The purpose of the present study was to assess the ovicidal and larvicidal activity of a hydroalcoholic extract (HAE) and their fractions (aqueous, Aq-F and organic, EtOAc-F) from Guazuma ulmifolia leaves using Haemonchus contortus as a biological model. The egg hatching inhibition (EHI) and larval mortality against infective larvae (L3) tests were used to determine the anthelmintic effect of the treatments. The extract and fractions were tested at different concentrations against eggs and L3. Additionally, distilled water and methanol were used as negative controls and ivermectin as a positive control. The extract and fractions were subjected to HPLC analysis to identify the major compounds. The HAE displayed the highest ovicidal activity (100% EHI at 10 mg/mL). Fractionation of the HA extract allowed increasing the nematicidal effect in the EtOAc-F (100% EHI at 0.62 mg/mL and 85.35% mortality at 25 mg/mL). The phytochemical analysis of the extract and fractions revealed the presence of kaempferol, ethyl ferulate, ethyl coumarate, flavonol, luteolin, ferulic acid, luteolin rhamnoside, apigenin rutinoside, coumaric acid derivative, luteolin glucoside, and quercetin glucoside. These results suggest that G. ulmifolia leaves could be potential candidates for the control of H. contortus or other gastrointestinal parasitic nematodes.

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