Comprehensive Expression Analysis Suggests Functional Overlapping of Human FOX Transcription Factors in Cancer

Zhang, Yali; FengTing, Sun; Zhang, Ze; Chen, Xiaoxu; Liu, Aixiang; Pan, Jingjing; Peng, Fei; Zhou, Shuai; Sun, Lijun

doi:10.7314/apjcp.2014.15.23.10475

Cited by 8 publications

(7 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genetic analyses indicated that many of these FOX genes are differentially expressed in a variety of diseases, including cancer 1 - 8 . Several FOX subfamilies, such as FOXA, FOXC, FOXM, FOXO and FOXP, are associated with tumorigenesis and cancer progression, playing roles as either oncogenes or tumor suppressors, depending on the family member and cell type 1 , 2 , 9 .…”

Section: Introduction: Overview Of Fox Proteins In Cancermentioning

confidence: 99%

The Emerging Roles of Forkhead Box (FOX) Proteins in Osteosarcoma

Zhang¹,

Duan²,

Song³

et al. 2017

J. Cancer

View full text Add to dashboard Cite

Osteosarcoma is the most common bone cancer primarily occurring in children and young adults. Over the past few years, the deregulation of a superfamily transcription factors, known as forkhead box (FOX) proteins, has been demonstrated to contribute to the pathogenesis of osteosarcoma. Molecular mechanism studies have demonstrated that FOX family proteins participate in a variety of signaling pathways and that their expression can be regulated by multiple factors. The dysfunction of FOX genes can alter osteosarcoma cell differentiation, metastasis and progression. In this review, we summarized the evidence that FOX genes play direct or indirect roles in the development and progression of osteosarcoma, and evaluated the emerging role of FOX proteins as targets for therapeutic intervention.

show abstract

Section: Introduction: Overview Of Fox Proteins In Cancermentioning

confidence: 99%

The Emerging Roles of Forkhead Box (FOX) Proteins in Osteosarcoma

Zhang¹,

Duan²,

Song³

et al. 2017

J. Cancer

View full text Add to dashboard Cite

show abstract

“…Due to the large number of FOX families, we focused on the key components of six subfamilies in this study. Studies have found that FOXA1, FOXM1, FOXO3, FOXP1 and so on play an important role in tumors as oncogenes or tumor suppressor genes (11).…”

Section: Introductionmentioning

confidence: 99%

The Role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast cancer

Hui

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Breast cancer is a common malignancy with the highest mortality rate among women worldwide. The Forkhead Box (FOX) transcription factor family is an evolutionarily conserved superfamily that regulates cell growth, differentiation, and tissue development. Increasing evidence suggests that FOX transcription factors play an important role in the occurrence and development of breast cancer. However, little is known about the relationship between the expression, prognostic value, function and immune infiltration of FOX transcription factors in tumor microenvironment.Methods In this research, we studied the expression, prognostic value, gene alteration, functional enrichment and immune cell infiltration of FOX factor in breast cancer patients by using the Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier plotter, cBioPortal, String, GeneMANIA, DAVID, TIMER, Cytoscape(version3.9.1)and R software (version 3.6.3).Results The expression levels of FOXA1 and FOXM1 were significantly higher in breast cancer tissues than in normal tissues, while the expression levels of FOXC2 and FOXO3 were lower in breast cancer tissues than in normal tissues. The high expression of mRNA in FOXA1, FOXM1 and FOXP1 groups was related to tumor stage. Survival analysis results showed that increased FOXP1 mRNA levels were significantly associated with overall survival (OS), recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) in all breast cancer patients (p < 0.05). Patients with the FOXA1 high-expression group had better RFS and DMFS than the low-expression group (p < 0.05), while patients with FOXM1 high-expression group had worse RFS, OS and DMFS than the low-expression group (p < 0.05). FOXP1, FOXA1 and FOXM1 can be used as potential biomarkers to predict the prognosis of breast cancer patients. Functional enrichment indicated that FOX was mainly involved in cell division, cell senescence, cell cycle and prolactin signaling pathway. In addition, FOX mRNA expression was strongly associated with the infiltration of multiple immune cells, including six types of B cells, CD4 + T cells, CD8 + T cells, macrophages, neutrophils, and dendritic cells in breast cancer.Conclusion These findings may provide novel insights into the screening of prognostic biomarkers of the FOX family in breast cancer, and lays a foundation for further research on the immune infiltration of the FOX transcription factor family members in tumors.

show abstract

“…[6][7][8] Over the past few years, deregulation of FOX proteins has been demonstrated to contribute to the pathogenesis of a variety of diseases, including glaucoma, language disorders, and cancers. [8][9][10] Genetic analyses have indicated that a loss or gain of FOX function might be implicated in promoting tumorigenesis as well as cancer progression. 11 As a consequence, FOX proteins are considered as direct or indirect targets for therapeutic intervention of cancers, as well as biomarkers for predicting and monitoring treatment responses.…”

Section: Introductionmentioning

confidence: 99%

“…Forkhead box (FOX) proteins are a large family of transcription factors, which have complex and important functions in multiple biological processes, such as cell‐cycle control, cell differentiation, proliferation and development . Over the past few years, deregulation of FOX proteins has been demonstrated to contribute to the pathogenesis of a variety of diseases, including glaucoma, language disorders, and cancers . Genetic analyses have indicated that a loss or gain of FOX function might be implicated in promoting tumorigenesis as well as cancer progression .…”

Section: Introductionmentioning

confidence: 99%

Knockdown of FOXJ1 inhibits the proliferation, migration, invasion, and glycolysis in laryngeal squamous cell carcinoma cells

Liu

Zhang

Shao

et al. 2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

Forkhead box (FOX) proteins are a large family of transcription factors that are involved in multiple biological processes. FOXJ1, a member of the FOX family, has been found to participate in tumorigenesis. However, the role of FOXJ1 in laryngeal squamous cell carcinoma (LSCC) is still unclear. The aim of the present study was to explore the potential roles of FOXJ1 in LSCC. Our results showed that FOXJ1 was overexpressed in LSCC tissues and cell lines. Then the small interfering RNA targeting FOXJ1 (FOXJ1‐siRNA) or control siRNA was transfected into TU‐177 and AMC‐HN‐8 cells to knockdown FOXJ1. Cell Counting Kit‐8 assay showed that knockdown of FOXJ1 inhibited the proliferation of LSCC cells. Transwell assay revealed that FOXJ1‐siRNA‐transfected cells showed significant reduction in cell migration and invasion compared to the cells transfected with control siRNA. FOXJ1 knockdown suppressed glycolysis in LSCC cells, which was illustrated by the reduced glucose consumption and lactate production. In addition, FOXJ1 knockdown inhibited the activation of the Wnt/β‐catenin pathway, and the LiCl treatment mitigated the inhibitory effects of FOXJ1‐siRNA on cell proliferation, migration, invasion, and glycolysis. These findings indicated that FOXJ1‐siRNA executed its functions via suppressing the activation of the Wnt/β‐catenin pathway.

show abstract

Comprehensive Expression Analysis Suggests Functional Overlapping of Human FOX Transcription Factors in Cancer

Cited by 8 publications

References 29 publications

The Emerging Roles of Forkhead Box (FOX) Proteins in Osteosarcoma

The Emerging Roles of Forkhead Box (FOX) Proteins in Osteosarcoma

The Role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast cancer

Knockdown of FOXJ1 inhibits the proliferation, migration, invasion, and glycolysis in laryngeal squamous cell carcinoma cells

Contact Info

Product

Resources

About