Comprehensive identification and expression profiling of immune-related lncRNAs and their target genes in the intestine of turbot (Scophthalmus maximus L.) in response to Vibrio anguillarum infection

Fu, Qiang; Li, Yuqing; Zhao, Shoucong; Wang, Haojie; Zhao, Chunyan; Zhang, Pei; Cao, Min; Li, Chao

doi:10.1016/j.fsi.2022.09.004

Cited by 5 publications

(1 citation statement)

References 61 publications

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“…JAKs were involved in the regulation of antiviral response, B-cell proliferation and specific antibody production in large yellow croaker (Larimichthys crocea) [22,23]. In recent years, extensive studies based on RNA-seq technology have revealed that JAKs are activated in response to different microbial pathogens in fishes, such as largemouth bass (Micropterus salmoides) [24], marbled rockfish (Sebastiscus marmoratus) [25], Chinese tongue sole (Cynoglossus semilaevis) [26], turbot (Scophthalmus maximus) [27,28], black rockfish (Sebastes schlegelii) [29], rainbow trout (Oncorhynchus mykiss) [30] and crucian carp (Carassius auratus) [31]. These results indicate that fish JAKs play important roles in immune response, providing a theoretical basis for understanding the biological functions of JAKs in fishes.…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterization and Expression Analysis of Four Janus Kinases (JAK1, JAK2a, JAK3 and TYK2) from Golden Pompano (Trachinotus ovatus)

Xie

Chen

Han

et al. 2023

Fishes

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Golden pompano, Trachinotus ovatus, is a perciform fish with great economic value and is widely cultured in the coastal areas of China. The wide occurrence of bacterial, parasitic and viral diseases has seriously threatened the sustainable development of the golden pompano culture industry. Janus kinases (JAKs) play important roles in most cytokine-mediated inflammatory responses, antiviral immune responses, autoimmune responses and disease pathologies. The present study aimed to obtain the full-length cDNA sequences of JAKs (JAK1, JAK2a, JAK3 and TYK2) from golden pompano and investigate their roles following stimulation with lipopolysaccharide (LPS), polyriboinosinic-polyribocytidylic acid (poly I:C) and Vibrio alginolyticus using RT-PCR, RACE-PCR and real-time qPCR methods. All four JAK proteins of golden pompano shared similar conserved domains, had high identities and clustered well with their teleost counterparts in phylogenetic analysis. Furthermore, these four genes were expressed in all examined tissues from healthy fish and induced in head kidney (HK), spleen, liver and gill post LPS, poly I:C and V. alginolyticus stimulation. Knowledge of the roles of JAKs in the immune response to different microbial pathogens provides a basis for further understanding of these functions.

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Section: Introductionmentioning

confidence: 99%

Molecular Characterization and Expression Analysis of Four Janus Kinases (JAK1, JAK2a, JAK3 and TYK2) from Golden Pompano (Trachinotus ovatus)

Xie

Chen

Han

et al. 2023

Fishes

View full text Add to dashboard Cite

show abstract

LncRNA activates immune response against Vibrio anguillarum in the intestine-liver axis of turbot (Scophthalmus maximus L.) by sponging miRNA in a ceRNA regulatory network

et al. 2023

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Comprehensive identification and expression profiling of immune-related lncRNAs and their target genes in the intestine of turbot (Scophthalmus maximus L.) in response to Vibrio anguillarum infection

Cited by 5 publications

References 61 publications

Molecular Characterization and Expression Analysis of Four Janus Kinases (JAK1, JAK2a, JAK3 and TYK2) from Golden Pompano (Trachinotus ovatus)

Molecular Characterization and Expression Analysis of Four Janus Kinases (JAK1, JAK2a, JAK3 and TYK2) from Golden Pompano (Trachinotus ovatus)

LncRNA activates immune response against Vibrio anguillarum in the intestine-liver axis of turbot (Scophthalmus maximus L.) by sponging miRNA in a ceRNA regulatory network

Comprehensive profiling of lncRNAs in the immune response of largemouth bass to Nocardia Seriolae infection

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