Comprehensive Magnetic Resonance Imaging of the Small and Large Bowel Using Intraluminal Dual Contrast Technique With Iron Oxide Solution and Water in Magnetic Resonance Enteroclysis

Herrmann, Karin; Zech, Christoph J.; Michaely, Henrik J.; Seiderer, Julia; Ochsenkuehn, Thomas; Reiser, Maximilian; Schoenberg, Stefan O.

doi:10.1097/01.rli.0000175037.15022.85

Cited by 37 publications

(21 citation statements)

References 32 publications

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“…Regarding the MRE technique, this and previous studies in our IBD cohort [6,12,14] have shown the high diagnostic value in small-bowel assessment in CD, particularly for the detection of extraluminal pathology such as internal fistulas or a characterization of inflammatory or fibrostenotic complications. MRE has the potential comprehensively to investigate the entire small-and large bowel in one session and therefore provides information on all intestinal segments even in the presence of multiple stenoses and particularly in segments inaccessible to endoscopy.…”

Section: Discussionmentioning

confidence: 94%

“…In particular, magnetic resonance enteroclysis (MRE) has provided a remarkable new quality of small-bowel visualization, providing high sensitivity and specificity in the identification of inflammatory stenoses, strictures, or fistulas [6,11,12,14]. However, CE and MRE are somewhat limited while only providing images rather than the possibility of biopsy sampling thus allowing histological proof of CD.…”

Section: Introductionmentioning

confidence: 98%

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Double-balloon enteroscopy versus magnetic resonance enteroclysis in diagnosing suspected small-bowel Crohn's disease: Results of a pilot study

Seiderer

Herrmann

Diepolder

et al. 2007

Scandinavian Journal of Gastroenterology

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In selected patients with suspected small-bowel lesions, DBE is a promising tool in the diagnostic work-up and provides the advantage of biopsy sampling. In contrast, non-invasive MRE delivers excellent information about extraluminal pathology associated with CD. Both MRE and DBE have the potential to become diagnostic standards that complement each other in patients with suspected complex small-bowel CD.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 98%

Double-balloon enteroscopy versus magnetic resonance enteroclysis in diagnosing suspected small-bowel Crohn's disease: Results of a pilot study

Seiderer

Herrmann

Diepolder

et al. 2007

Scandinavian Journal of Gastroenterology

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“…MR enteroclysis requires extensive patient preparation and should be performed utilizing an intraabdominal tube for complete distension of the small bowel loops [21]. Therefore, it is not well tolerated and accepted by patients Fig.…”

Section: Discussionmentioning

confidence: 99%

Functional cine MR imaging for the detection and mapping of intraabdominal adhesions: method and surgical correlation

et al. 2008

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The purpose of this study was to evaluate the presence and localization of intraabdominal adhesions using functional cine magnetic resonance imaging (MRI) and to correlate the MR findings with intraoperative results. In a retrospective study, patients who had undergone previous abdominal surgery with suspected intraabdominal adhesions were examined. A true fast imaging with steady state precession sequence in transverse/sagittal orientation was used for a section-by-section dynamic depiction of visceral slide on a 1.5-Tesla system. After MRI, all patients underwent anew surgery. A nine-segment abdominal map was used to document the location and type of the adhesions. The intraoperative results were taken as standard of reference. Ninety patients were enrolled. During surgery 71 adhesions were detected, MRI depicted 68 intraabdominal adhesions. The most common type of adhesion in MRI was found between the anterior abdominal wall and small bowel loops (n = 22, 32.5%) and between small bowel loops and pelvic organs (n = 14, 20.6%). Comparing MRI with the intraoperative findings, sensitivity varied between 31 and 75% with a varying specificity between 65 and 92% in the different segments leading to an overall MRI accuracy of 89%. Functional cine MRI proved to be a useful examination technique for the identification of intraabdominal adhesions in patients with acute or chronic pain and corresponding clinical findings providing accurate results. However, no differentiation for symptomatic versus asymptomatic adhesions is possible.

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“…This can be used to prevent overlapping in magnetic resonance cholangiopancreatography (MRCP), for better delimitation with respect to structures adjacent to the bowel (e. g. lymph nodes or uterus) and the evaluation (postoperative) of anatomical changes to the bowel [86], as well as for the detection of inflammatory bowel lesions after i. v. administration [87].…”

Section: Imaging Of the Gastrointestinal Tractmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Ittrich¹,

Peldschus²,

Raabe³

et al. 2013

Fortschr Röntgenstr

125

101

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Superparamagnetic iron oxide nanoparticles (SPIO) can be used to image physiological processes and anatomical, cellular and molecular changes in diseases. The clinical applications range from the imaging of tumors and metastases in the liver, spleen and bone marrow, the imaging of lymph nodes and the CNS, MRA and perfusion imaging to atherosclerotic plaque and thrombosis imaging. New experimental approaches in molecular imaging describe undirected SPIO trapping (passive targeting) in inflammation, tumors and associated macrophages as well as the directed accumulation of SPIO ligands (active targeting) in tumor endothelia and tumor cells, areas of apoptosis, infarction, inflammation and degeneration in cardiovascular and neurological diseases, in atherosclerotic plaques or thrombi. The labeling of stem or immune cells allows the visualization of cell therapies or transplant rejections. The coupling of SPIO to ligands, radio- and/or chemotherapeutics, embedding in carrier systems or activatable smart sensor probes and their externally controlled focusing (physical targeting) enable molecular tumor therapies or the imaging of metabolic and enzymatic processes. Monodisperse SPIO with defined physicochemical and pharmacodynamic properties may improve SPIO-based MRI in the future and as targeted probes in diagnostic magnetic resonance (DMR) using chip-based ?NMR may significantly expand the spectrum of in vitro analysis methods for biomarker, pathogens and tumor cells. Magnetic particle imaging (MPI) as a new imaging modality offers new applications for SPIO in cardiovascular, oncological, cellular and molecular diagnostics and therapy. Key Points: Citation Format:

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Comprehensive Magnetic Resonance Imaging of the Small and Large Bowel Using Intraluminal Dual Contrast Technique With Iron Oxide Solution and Water in Magnetic Resonance Enteroclysis

Abstract: Comprehensive MR imaging of SB and LB with DCT improves the identification of modified anatomy and most pathologies in inflammatory and postsurgical bowel.

Cited by 37 publications

References 32 publications

Double-balloon enteroscopy versus magnetic resonance enteroclysis in diagnosing suspected small-bowel Crohn's disease: Results of a pilot study

Double-balloon enteroscopy versus magnetic resonance enteroclysis in diagnosing suspected small-bowel Crohn's disease: Results of a pilot study

Functional cine MR imaging for the detection and mapping of intraabdominal adhesions: method and surgical correlation

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

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