Comprehensive review on ethnobotanical uses, phytochemistry, biological potential and toxicology of Parthenium hysterophorus L.: A journey from noxious weed to a therapeutic medicinal plant

Kaur, Loveleen; Malhi, Dharambeer Singh; Cooper, Raymond; Kaur, Mandeep; Sohal, Harvinder Singh; Mutreja, Vishal; Sharma, Ajay

doi:10.1016/j.jep.2021.114525

Cited by 34 publications

(16 citation statements)

References 154 publications

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“…The use of medicinal plants is a centuries-old tradition, and recent advances in contemporary therapies have boosted the use of natural products for a variety of maladies and disorders around the world [15]. Secondary metabolites have a variety of biological effects, and they provide the scientific foundation for many ancient civilizations' uses of herbs in traditional medicine [16]. Phenolic compounds are widely distributed and the most abundant secondary metabolites in plants; they include flavonoids, alkaloids, and phenolic acids, which are involved in the defense against ultraviolet radiation or aggression by pathogens, parasites, and predators [17].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Phytochemical and Pharmacological Potential of Taif’s Rose (Rosa damascena Mill var. trigintipetala) for Possible Recycling of Pruning Wastes

Galal

Al-Yasi

Fawzy

et al. 2022

Life

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This study investigated the phytochemical contents of Taif’s rose pruning wastes and their potential application as phytomedicine, thereby practicing a waste-recycling perspective. In the Al-Shafa highland, four Taif rose farms of various ages were chosen for gathering the pruning wastes (leaves and stems) for phytochemical and pharmacological studies. The leaves and stems included significant amounts of carbohydrates, cardiac glycosides, alkaloids, flavonoids, and other phenolic compounds. The cardiac glycoside and flavonoid contents were higher in Taif rose stems, while the phenolic and alkaloid contents were higher in the plant leaves. Cardiovascular glycosides (2.98–5.69 mg g−1), phenolics (3.14–12.41 mg GAE g−1), flavonoids (5.09–9.33 mg RUE g −1), and alkaloids (3.22–10.96 mg AE g−1) were among the phytoconstituents found in rose tissues. According to the HPLC analysis of the phenolic compounds, Taif’s rose contains flavonoid components such as luteolin, apigenin, quercetin, rutin, kaempferol, and chrysoeriol; phenolics such as ellagic acid, catechol, resorcinol, gallic acid, and phloroglucinol; alkaloids such as berbamine, jatrorrhizine, palmatine, reticuline, isocorydine, and boldine. Warm water extract was highly effective against Bacillus subtilis, Escherichia coli, and Proteus vulgaris, whereas methanol and cold water extracts were moderately effective against Aspergillus fumigatus and Candida albicans. The study’s findings suggested that Taif’s rose wastes could be used for varied medical purposes.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Phytochemical and Pharmacological Potential of Taif’s Rose (Rosa damascena Mill var. trigintipetala) for Possible Recycling of Pruning Wastes

Galal

Al-Yasi

Fawzy

et al. 2022

Life

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“…It is a fast-maturing annual weed with a deep root and an erect stem that becomes woody with age. Due to its allelopathic impact, this weed is believed to cause allergic respiratory problems, mutagenicity in humans and livestock, and severe reductions in agricultural production [14,15]. A research study performed by Bajwa et al [16], demonstrated that this toxic and aggressive species is one of the worst weeds in the world.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Investigation, Antioxidant Properties and In Vivo Evaluation of the Toxic Effects of Parthenium hysterophorus

Iqbal

Khan

Aziz³

et al. 2022

Molecules

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Parthenium hysterophorus L. is a poisonous Asteraceae weed. The phytochemical profile, antioxidant activity, total phenolic contents (TPC), total flavonoid contents (TFC), and cytotoxicity of Parthenium hysterophorus L. flower extract were evaluated in this study, and the toxic effects were assessed in rabbits. The HPLC-DAD system was used for phytochemical analysis. The hemolytic and DPPH assays were performed. The effects of orally administering the flower crude extract to rabbits (n = 5) at four different doses (10, 20, 40, and 80 mg/kg) for ten days on hematological and biochemical parameters were investigated. The crude extract of the flower contained phenolic compounds such as Gallic acid, Chlorogenic acid, Ellagic acid, and P Coumaric acid, which were detected at different retention times, according to the HPLC results. With a sample peak of 4667.475 %, chlorogenic acid was abundant. At concentrations of 80 µg, the methanolic extract of flowers had total phenolic contents (89.364 ± 4.715 g GAE/g) and total flavonoid contents (65.022 ± 2.694 g QE/g). In the DPPH free radical scavenging assay, 80 µg of extract had the highest cell inhibition of 76.90% with an IC50 value of 54.278 µg/µL, while in the hemolytic assay 200 µg of extract had the highest cell inhibition of 76.90% with an IC50 > 500. The biochemical and hematological parameters were altered in the flower extract-fed groups as compared to the control (p < 0.05). The toxic effects on the blood, liver, and kidneys were confirmed. The findings also confirmed the presence of phenolic and flavonoid content in the flower extract, both of which contribute to the plant’s antioxidant potential.

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“…Medicinal plants are readily available sources of a wide range of phytochemical constituents for the prevention and treatment of various medical conditions (Dutra et al 2016).These secondary metabolites have many biological actions, which give the scientific evidence for utilizing the herbal products in traditional medical practice in various communities (Kaur et al 2021). Most people in developing nations rely on herbal medicines for basic treatment and other healthcare needs (Senthilkumar et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Ethnomedicinal applications, phytochemistry, and pharmacological properties of Laggera aurita Linn (Asteraceae): A Review

et al. 2022

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Background The plant Laggera aurita (Asteraceae) is a commonly utilized medicinal plant growing as a weed in African countries used in the treatment of many diseases. Besides, several phytochemical and pharmacological studies were conducted to check its phytocompounds and therapeutic potentials. However, there is unavailable information on the plant documenting its ethnomedicinal uses and medicinal properties. Therefore, the current article aims to provide updated information on the ethnomedicinal values, phytochemical compounds, and therapeutic potentials of Laggera aurita for further studies to develop noble bioactive molecules. Main text Studies regarding the plant Laggera aurita were sourced from online academic databases such as Google Scholar and PubMed. The search terms used include Laggera aurita, ethnomedicinal uses, phytochemistry, pharmacological activity, and toxicology. The plant has ethnomedicinal applications against epilepsy, cancer, atherosclerosis, thrombosis, malaria, fever, pain, stomatitis, asthma, bronchitis, nasal congestion, infections, rheumatism, dyspepsia, indigestion, constipation, dysentery, and many more. Several phytochemical agents were isolated from various plant parts. Besides, pharmacological studies have shown that the plant has antipyretic, analgesic, anti-inflammatory, anticonvulsant, anxiolytic, antimicrobial, antimalarial, and antioxidant effects. Conclusions Various pharmacological evaluations conducted on the plant have validated the traditional values of the plant Laggera aurita. However, more research is paramount to validate many of the reported traditional uses. Also, the phytochemical molecules need to be screened for biological properties to develop potential therapeutic agents. The plant is relatively safe on sub-chronic administration and slightly toxic in acute studies. Hence, further toxicological studies on the plant are required to establish its safety. There is a need to also standardize doses to establish safety and efficacy.

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Comprehensive review on ethnobotanical uses, phytochemistry, biological potential and toxicology of Parthenium hysterophorus L.: A journey from noxious weed to a therapeutic medicinal plant

Cited by 34 publications

References 154 publications

Evaluation of the Phytochemical and Pharmacological Potential of Taif’s Rose (Rosa damascena Mill var. trigintipetala) for Possible Recycling of Pruning Wastes

Evaluation of the Phytochemical and Pharmacological Potential of Taif’s Rose (Rosa damascena Mill var. trigintipetala) for Possible Recycling of Pruning Wastes

Phytochemical Investigation, Antioxidant Properties and In Vivo Evaluation of the Toxic Effects of Parthenium hysterophorus

Ethnomedicinal applications, phytochemistry, and pharmacological properties of Laggera aurita Linn (Asteraceae): A Review

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