Comprehensive Score for Financial Toxicity and Health-Related Quality of Life in Patients With Cancer and Survivors: A Systematic Review and Meta-Analysis

Pangestu, Stevanus; Rencz, Fanni

doi:10.1016/j.jval.2022.07.017

Cited by 32 publications

(23 citation statements)

References 82 publications

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“… 1–8 These costs are associated with worse financial outcomes, but also psychological distress and inadequate access to care. Financial burden has been associated with reduced quality of life, poor family functioning, depression/anxiety, cognitive impairment, and sleep impairment 9–12 …”

Section: Introductionmentioning

confidence: 99%

“…Financial burden has been associated with reduced quality of life, poor family functioning, depression/anxiety, cognitive impairment, and sleep impairment. [9][10][11][12] We chose to investigate three measures of financial burden: household material hardship (HMH), financial toxicity, and income loss (Table S1). HMH is a particularly salient measure, because it has been associated with poor health outcomes, 13 increased emergency department utilization, and higher rates of hospitalization.…”

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confidence: 99%

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Disparities in household material hardship, financial toxicity, and income loss in pediatric cancer

Evans

Lin

Sanchez-Alvarez

et al. 2023

Pediatric Blood & Cancer

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Background: Based on previous reports of disparities in financial burden following a cancer diagnosis, this study aims to characterize mechanisms of disparities experienced by caregivers of children with cancer, including the impact of work flexibility and social support. Methods:Cross-sectional survey (in English or Spanish) of caregivers of children with cancer that assessed household material hardship (HMH), financial toxicity, and income change.Results: Of 156 caregivers surveyed, 32% were Hispanic and 32% were low income.Hispanic caregivers were more likely to report HMH and financial toxicity compared to non-Hispanic White and Asian (HMH: 57% vs. 21% vs. 19%, p < .001; financial toxicity: 73% vs. 52% vs. 53%, p = .07). Low-and middle-income caregivers were more likely to experience HMH and financial toxicity compared to high-income caregivers (HMH: 68% low vs. 38% middle vs. 8.7% high, p < .001; financial toxicity: 81% vs. 68% vs. 44%, p < .001). All income categories demonstrated significant increases in HMH 1 year after diagnosis. Seventeen percent reported more than 40% income loss, more of whom were low income than high income (27% vs. 12%, p = .20). Work flexibility and social support were associated with income and financial toxicity. Conclusion:HMH, financial toxicity, and income loss are prevalent after a child's cancer diagnosis, suggesting that screening should be incorporated into routine care. This financial burden disproportionately affects low-income and Hispanic caregivers. Further research is needed to elucidate the roles of work flexibility and social support, how safety net services are utilized by families, and how best to support families with HMH.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Disparities in household material hardship, financial toxicity, and income loss in pediatric cancer

Evans

Lin

Sanchez-Alvarez

et al. 2023

Pediatric Blood & Cancer

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“…Financial toxicity, defined as the combination of objective financial burden and psychological distress related to financial concerns, plays a significant role in the noted decrease in quality of life of cancer patients [5,6,[10][11][12][13][14]15 && , 16,17]. Patients with cancer are particularly vulnerable due to the substantial costs of treatment and surveillance [6,10,17-22,23 & ,24].…”

Section: Introductionmentioning

confidence: 99%

“…COST has allowed for many subjective analyses on the effects of financial burden on quality of life. These studies have established a connection between financial toxicity and health-related quality of life (HRQoL), including physical health, social health, mental health, and daily functioning [10][11][12][13][14]15 && ,30 -34]. Initial data showed race, employment status, income, number of inpatient admissions, and psychosocial distress were independent factors for financial toxicity.…”

Section: Introductionmentioning

confidence: 99%

“…Further, when controlling for other variables, the strongest predictor of a decrease in quality of life was the degree to which cancer caused financial problems [10]. Many subsequent studies have revealed younger age, female sex, lower income, and limited or no insurance coverage as the most prominent risk factors, with patients lacking insurance being at twice the risk for financial burden [6,10,12,14,15 ▪▪ ,16,17,20,22,23 ▪ ,24,25,28–31,35–45]. Additionally, patients with financial burden are over three times more likely to suffer from depression and psychological distress and are more likely to report poor physical health, mental health, and satisfaction with social activities and relationships than those with no financial hardship [13].…”

Section: Introductionmentioning

confidence: 99%

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Financial toxicity in thyroid cancer survivors

Bogdanovski

Sturgeon

James

2023

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of review Financial burden and distress are high in patients with thyroid cancer. However, little has been done to evaluate potential interventions to mitigate financial toxicity in survivors. This review will cover current data on the impact of financial toxicity on quality of life and clinical outcomes in patients with thyroid cancer and highlight areas for future study. Recent findings Thyroid cancer incidence has nearly tripled in the past decades, and cost of treatment is predicted to rise more than other cancers over the next decade. With mean age of diagnosis at 51 years, most patients begin treatment while still working, do not qualify for Medicare or Social Security, and are susceptible to higher financial burden. Though thyroid cancer has high survival rates, some studies suggest patients have worse quality of life and higher financial burden than more morbid cancers. Summary Thyroid cancer survivors have high rates of financial toxicity, and there remains need for longitudinal studies to evaluate how financial burden may change during the treatment process while also assessing potential tools to mitigate this burden.

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Greater financial toxicity correlates with increased psychological distress and lower quality of life among Turkish cancer patients

Yücel

Özay

Sütçüoğlu

et al. 2023

Support Care Cancer

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Comprehensive Score for Financial Toxicity and Health-Related Quality of Life in Patients With Cancer and Survivors: A Systematic Review and Meta-Analysis

Cited by 32 publications

References 82 publications

Disparities in household material hardship, financial toxicity, and income loss in pediatric cancer

Disparities in household material hardship, financial toxicity, and income loss in pediatric cancer

Financial toxicity in thyroid cancer survivors

Greater financial toxicity correlates with increased psychological distress and lower quality of life among Turkish cancer patients

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