Comprehensive transcriptional profiling of porcine brain aging

Chen, Jianning; Zou, Qin; Lv, Daojun; Raza, Muhammad Ali; Wang, Xue; Li, Peilin; Yan, Chen; Xi, Xiaoyu; Wen, Anxiang; Zhu, Li; Tang, Guoqing; Li, Mingzhou; Li, Xuewei; Jiang, Yanzhi

doi:10.1016/j.gene.2019.01.019

Cited by 16 publications

(12 citation statements)

References 44 publications

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“…A total of 11276 circRNAs were generated, of which 6790 circRNAs were detected in the brain, 5712 in the pituitary, 4937 in the ovary and 4160 in the liver. Most of the putative circRNAs we identified in tongue sole were expressed at low levels, which is consistent with recent studies [ 3 , 24 ] and suggests little potential function of most circRNAs [ 28 , 29 , 30 , 31 ]. In the current study, most circRNAs were derived from exons of genes, which was similar to those in human organs [ 32 , 33 ].…”

Section: Discussionsupporting

confidence: 91%

Comprehensive CircRNA Profiling and Selection of Key CircRNAs Reveal the Potential Regulatory Roles of CircRNAs throughout Ovarian Development and Maturation in Cynoglossus semilaevis

Bao

Wang

et al. 2021

Biology

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CircRNAs are novel endogenous non-coding small RNAs involved in the regulation of multiple biological processes. However, little is known regarding circRNAs in ovarian development and maturation of fish. Our study, for the first time, provides the genome-wide overview of the types and relative abundances of circRNAs in tongue sole tissues during three ovarian developmental stages. We detected 6790 circRNAs in the brain, 5712 in the pituitary gland, 4937 in the ovary and 4160 in the liver. Some circRNAs exhibit tissue-specific expression, and qRT-PCR largely confirmed 6 differentially expressed (DE) circRNAs. Gene Ontology and KEGG pathway analyses of DE mRNAs were performed. Some DE circRNA parental genes were closely associated with biological processes in key signalling pathways and may play essential roles in ovarian development and maturation. We found that the selected circRNAs were involved in 10 pathways. RNase R digestion experiment and Sanger sequencing verified that the circRNA had a ring structure and was RNase R resistant. qRT-PCR results largely confirmed differential circRNA expression patterns from the RNA-seq data. These findings indicate that circRNAs are widespread in terms of present in production-related tissues of tongue sole with potentially important regulatory roles in ovarian development and maturation.

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Section: Discussionsupporting

confidence: 91%

Comprehensive CircRNA Profiling and Selection of Key CircRNAs Reveal the Potential Regulatory Roles of CircRNAs throughout Ovarian Development and Maturation in Cynoglossus semilaevis

Bao

Wang

et al. 2021

Biology

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“…However, the use of pigs in aging research is limited, as even in a translational setting, most pigs are euthanized at a relatively young age. Researchers have found age-related transcriptional changes in pig brain (Chen et al 2019b), liver (Chen et al 2019a), and skeletal muscle (Chen et al 2018), but samples sizes were very low. While not the standard farm-raised pig, studies in the micropig, very small pigs arising from crosses of commercial and native pigs that are often kept as companion pets, suggest that agerelated changes in the microbiome are similar to those in humans (Lim et al 2019), and we hypothesize that similar patterns would be seen in agriculturally raised pigs, due to the close relationship between the two species.…”

Section: Loss Of Reproductive Functionmentioning

confidence: 99%

A short life on the farm: aging and longevity in agricultural, large-bodied mammals

Hoffman

Valencak

2020

GeroScience

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As average human lifespans increase across the globe, companion animals, specifically dogs and cats, are also living longer with more age-related morbidities. However, a similar trend is not seen in mammalian livestock species. Cows, pigs, goats, and sheep, as well as more niche mammalian species raised across the world, have been primarily raised for their economic benefit to humans and are culled from the population once their production declines. To this end, we lack clear knowledge about the age-related morbidities and causes of death that afflict livestock animals due to natural aging, as well as detailed age-specific survival rates. Here, we review the current state of the field of agricultural mammal aging, as well as provide specific questions and directions that may provide novel resources for veterinarians and aging biologists. By raising awareness of the overall quality of life and ongoing health of individual livestock animals, we can potentially increase production into older life stages, leading to decreased costs to farmers and improved welfare for the animals themselves.

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“…In addition to the early stages of development, investigators are also interested in the expression of circRNAs in the aging nervous system. To date, several studies have shown that age-related circRNA accumulation exists in various animals (Westholm et al, 2014;Gruner et al, 2016;Cortes-Lopez et al, 2018;Chen et al, 2019). Drosophila melanogaster RNA-Seq libraries reveal this phenomenon for the first time.…”

Section: Age-related Accumulationmentioning

confidence: 95%

“…This result revealed that the age-dependent accumulation was progressive. In addition, aging-related accumulation of circRNAs was found in C. elegans and porcine brain (Cortes-Lopez et al, 2018;Chen et al, 2019). The latest research on rhesus monkeys showed that 11 circRNAs and host mRNAs are involved in regulating brain aging (Xu et al, 2020).…”

Section: Age-related Accumulationmentioning

confidence: 99%

Circular RNAs in the Central Nervous System

Wang

Jin

2021

Front. Mol. Biosci.

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Circular RNAs (circRNAs) are endogenous single-stranded RNAs characterized by covalently closed loop structures with neither 5′ to 3′ polarity nor poly(A) tails. They are generated most commonly from back-splicing of protein-coding exons. CircRNAs have a tissue-specific distribution and are evolutionarily conserved, and many circRNAs play important biological functions by combining with microRNAs and proteins to regulate protein functions and their own translation. Numerous studies have shown that circRNAs are enriched in the central nervous system (CNS) and play an important role in the development and maintenance of homeostasis. Correspondingly, they also play an important role in the occurrence and progression of CNS diseases. In this review, we highlight the current state of circRNA biogenesis, properties, function and the crucial roles they play in the CNS.

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Comprehensive transcriptional profiling of porcine brain aging

Cited by 16 publications

References 44 publications

Comprehensive CircRNA Profiling and Selection of Key CircRNAs Reveal the Potential Regulatory Roles of CircRNAs throughout Ovarian Development and Maturation in Cynoglossus semilaevis

Comprehensive CircRNA Profiling and Selection of Key CircRNAs Reveal the Potential Regulatory Roles of CircRNAs throughout Ovarian Development and Maturation in Cynoglossus semilaevis

A short life on the farm: aging and longevity in agricultural, large-bodied mammals

Circular RNAs in the Central Nervous System

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