Compression analysis for assessment of pellet plasticity: Identification of reactant pores and comparison between Heckel, Kawakita, and Adams equations

Persson, Ann-Sofie; Nordström, Josefina; Frenning, Göran; Alderborn, Göran

doi:10.1016/j.cherd.2016.01.028

Cited by 26 publications

(9 citation statements)

References 26 publications

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“…In the present study the Kawakita-Lüdde and Walker compression models were applied to estimate the compressibility characteristics and the deformation mechanism of the API and API-TNT composite containing powder mixtures. The widely used Kawakita-Lüdde model [13] describes the volume reduction of the powder at a given compression pressure as a function of the pressure and therefore makes the analysis of particle rearrangement and compactibility possible. However, it does not give much information about the deformation mechanism of the powders, thus it is necessary to complement the analysis with another model.…”

Section: Introductionmentioning

confidence: 99%

Comparative study on the rheological properties and tablettability of various APIs and their composites with titanate nanotubes

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Comparative study on the rheological properties and tablettability of various APIs and their composites with titanate nanotubes

et al. 2017

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“…Ductile breakage has been observed for loose structures with a low bond stiffness [14,15]. Semi-brittle breakage is typical for intermediate compacted structures with an intermediate bond stiffness [11,17]. This classification was clearly reflected by the results of the experimental study of Ge et al [51], involving the breakage of 3D-printed agglomerates of dense and loose structures with rigid and soft bonds, which elucidated the effects of the packing density, inter-particle bond strength, and elasticity.…”

Section: Discussionmentioning

confidence: 90%

“…characterised by a round force-displacement response are considered semi-brittle. Semi-brittle materials include polymers [8,9], inorganic materials connected by a soft binder [10], and pharmaceutical granules [11]. Materials with loose structures and a low bond stiffness that exhibit a significant amount of fully plastic deformation prior to failure are considered ductile [5].…”

Section: Materials With Intermediate Compacted Structures and An Intementioning

confidence: 99%

Discrete Element Method Modelling of the Diametral Compression of Starch Agglomerates

et al. 2020

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Starch agglomerates are widely applied in the pharmaceutical, agricultural, and food industries. The formation of potato starch tablets and their diametral compression were simulated numerically and verified in a laboratory experiment to analyse the microscopic mechanisms of the compaction and the origins of their breakage strength. Discrete element method (DEM) simulations were performed using EDEM software. Samples comprised of 120,000 spherical particles with radii normally distributed in the range of 5–36 μm were compacted in a cylindrical die with a diameter of 2.5 cm. The linear elastic–plastic constitutive contact model with a parallel bonded-particle model (BPM) was used to model the diametral compression. DEM simulations indicated that the BPM, together with the linear elastic–plastic contact model, could describe the brittle, semi-brittle, or ductile breakage mode, depending on the ratio of the strength to Young’s modulus of the bond and the bond-to-contact elasticity ratio. Experiments confirmed the findings of the DEM simulations and indicated that potato starch (PS) agglomerates can behave as a brittle, semi-brittle, or ductile material, depending on the applied binder. The PS agglomerates without any additives behaved as a semi-brittle material. The addition of 5% of ground sugar resulted in the brittle breakage mode. The addition of 5% gluten resulted in the ductile breakage mode.

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“…Moreover, the post-compressional properties of the tablets could also be determined with the same equipment and taken into consideration. The suitability of this methodology has already been proven by the work of Viana et al in comparing the compression performance of different types of celluloses [29]. The present work attempted to test the powder functionality of various API–TNT composites, and thereby investigate a completely unexplored but quite reasonable aspect of these composites, which may open new directions in the tabletting of nano-sized APIs.…”

Section: Introductionmentioning

confidence: 93%

“…In order to be able to draw useful and correct conclusions, four different APIs and their composites formed with TNTs were examined and compared regarding their mechanical properties. The powder compression mechanisms of materials are usually estimated by fitting data into mathematical (Heckel [23,24], Walker [25] and Kawakita-Lüdde [26]) models, which are widely used in the field of pharmaceutical technology [27,28,29]. However, it is notable that, besides some critical issues [30], these models describe only a given part of the compression cycle, and need to be combined with each other to give a complete view of the process.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Compressibility and Compactibility of Titanate Nanotube-API Composites

et al. 2018

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The present work aims to reveal the pharma-industrial benefits of the use of hydrothermally synthesised titanate nanotube (TNT) carriers in the manufacturing of nano-sized active pharmaceutical ingredients (APIs). Based on this purpose, the compressibility and compactibility of various APIs (diltiazem hydrochloride, diclofenac sodium, atenolol and hydrochlorothiazide) and their 1:1 composites formed with TNTs were investigated in a comparative study, using a Lloyd 6000R uniaxial press instrumented with a force gauge and a linear variable differential transformer extensometer. The tablet compression was performed without the use of any excipients, thus providing the precise energetic characterisation of the materials’ behaviour under pressure. In addition to the powder functionality test, the post-compressional properties of the tablets were also determined and evaluated. The results of the energetic analysis demonstrated that the use of TNTs as drug carriers is beneficial in every step of the tabletting process: besides providing better flowability and more favourable particle rearrangement, it highly decreases the elastic recovery of the APIs and results in ideal plastic deformation. Moreover, the post-compressional properties of the TNT–API composites were found to be exceptional (e.g., great tablet hardness and tensile strength), affirming the above results and proving the potential in the use of TNT carriers for drug manufacturing.

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Compression analysis for assessment of pellet plasticity: Identification of reactant pores and comparison between Heckel, Kawakita, and Adams equations

Cited by 26 publications

References 26 publications

Comparative study on the rheological properties and tablettability of various APIs and their composites with titanate nanotubes

Comparative study on the rheological properties and tablettability of various APIs and their composites with titanate nanotubes

Discrete Element Method Modelling of the Diametral Compression of Starch Agglomerates

Investigation of the Compressibility and Compactibility of Titanate Nanotube-API Composites

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