Compression, Mechanical and Release Properties of Chloroquine Phosphate Tablets containing corn and Trifoliate Yam Starches as Binders

Adetunji, Oluwaseyi Adegoke; Odeniyi, Michael Ayodele; Itiola, O. A.

doi:10.4314/tjpr.v5i2.14636

Cited by 25 publications

(33 citation statements)

References 12 publications

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“…Determination of Particle Density : Particle densities of the Acha starches were determined using the Pycnometer method and xylene was used as the displacement fluid …”

Section: Methodsmentioning

confidence: 99%

Native and Modified Digitaria exilis Starch Nanoparticles as a Carrier System for the Controlled Release of Naproxen

2019

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Acha (Digitaria exilis) starches are investigated as nanocrystal carriers for the controlled release of naproxen. Starch nanocrystals (SNC) are prepared by acid hydrolysis using H2SO4 and the modified form (carboxymethylated SNC) is obtained by reaction of the SNC with monochloroacetic acid and sodium hydroxide. Physicochemical properties, degree of substitution, SEM and FTIR analyses, loading and release studies including in vitro release kinetics of the drug‐loaded starch nanocrystals are determined. FTIR analysis confirms the introduction of the hydrophilic carboxylate functional group into the starch molecule of the modified starches with strong peaks in the region 1300–1650 cm−1. SEM images reveal the disruption of the granular structure of the starch particles due to hydrolysis conferring crystallinity on the granules. The drug release kinetics of all the starch polymers follow the Korsemeyer–Peppas model indicating that the drug release was by non‐Fickian diffusion. The native starch, starch nanocrystals, and carboxymethylated nanocrystal forms have drug loading content that are above 50% and loading efficiency above 75% and produce a steady and sustained release of naproxen. The release studies of native Acha starch and the modified SNC show that their formulations can function as carriers/polymers that can achieve sustained and/or delayed drug release of poorly soluble drugs.

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“…Determination of Particle Density : Particle densities of the Acha starches were determined using the Pycnometer method and xylene was used as the displacement fluid …”

Section: Methodsmentioning

confidence: 99%

Native and Modified Digitaria exilis Starch Nanoparticles as a Carrier System for the Controlled Release of Naproxen

2019

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“…P y indicates the onset of plastic determination, while P k indicates the ability to deform plastically under pressure. The D i value is a measure of the packed initial relative density with the application of small pressures or tapping (Adetunji et al, 2006). Low values were recorded for all of the formulations.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Cedrela gum as a binder and bioadhesive component in ibuprofen tablet formulations

Odeniyi

Babalola

Ayorinde

2013

Braz. J. Pharm. Sci.

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The compressional, mechanical and bioadhesive properties of tablet formulations incorporating a new gum obtained from the incised trunk of the Cedrela odorata tree were evaluated and compared with those containing hydroxypropylmethylcellulose (HPMC). Compressional properties were evaluated using Hausner's ratio, Carr's Index, the angle of repose, and Heckel, Kawakita and Gurnham plots. Ibuprofen tablets were prepared using the wet granulation method. Bioadhesive studies were carried out using the rotating cylinder method in either phosphate buffer pH 6.8 or 0.1 M hydrochloric acid media. The gum is a low viscosity polymer (48 cPs), and Fourier transform infrared spectroscopy revealed the presence of a hydroxyl group. P y and P k values, which are measures of plasticity, showed the gum to be significantly (p<0.05) more plastic than HPMC, and plasticity increased with polymer concentration. All tablet formulations were non-friable (<1.0%), and the formulations containing the gum had a higher crushing strength (130.95 N) than those containing HPMC (117.85 N) at 2.0% w/w binder. Formulations incorporating the gum were non-disintegrating and had a significantly longer drug release time than those containing HPMC. At the highest binder concentration, Cedrela gum formulations adhered to incised pig ileum longer than those containing HPMC. Cedrela gum exhibited better compressive, flow and binding properties than HPMC and is suitable as a bioadhesive and for sustained release of drugs.Uniterms: Cedrela gum/evaluation/compression properties. Cedrela gum/bioadhesive component. Tablet formulations. Hydroxypropylmethylcellulose. Ibuprofen tablets/bioadhesive studies. Bioadhesion.Propriedades de compressão, mecânicas e de formulações de comprimidos bioadesivos, que incorporam nova goma de mascar obtidas a partir de incisão de tronco da árvore de Cedrela odorata, foram avaliadas e comparadas com aquelas contendo hidroxipropilmetilcelulose (HPMC). Propriedades de compressão foram avaliadas usando a razão de Hausner, índice de Carr, ângulo de repouso e os gráficos de Heckel, Kawakita e Gurnham. Prepararam-se comprimidos de ibuprofeno utilizando o método de granulação a úmido. Realizaram-se estudos de bioadesividade utilizando o método de cilindro rotativo em tampão fosfato pH 6,8, ou meio ácido com 0,1 M de ácido clorídrico. A goma é um polímero de baixa viscosidade (48 cPs) e a espectroscopia no infravermelho por Transformada de Fourier (FTIR) revelou a presença de um grupo hidroxila. Valores de Py e Pk, que são medidas de plasticidade, mostraram que a goma é significativamente (p <0,05) mais plástica do que HPMC e que a plasticidade aumenta com a concentração de polímero. Todas as formulações de comprimidos mostraram-se não-friáveis (<1,0%) e aquelas contendo a goma apresentaram maior resistência ao esmagamento (130.95N) do que aquelas contendo HPMC (117.85N) em 2,0% (p/p) do ligante. As formulações que incorporaram a goma eram não-desintegrantes e apesentaram tempo de liberação significativamente maior do que aquelas contend...

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“…The particle density of paracetamol powder and the modified starches were determined as described by Adetunji et al…”

Section: Methodsmentioning

confidence: 99%

“…They may be prepared by any of the methods of granulation or direct compression. Direct compression is an attractive method for tablet production due to its cost effectiveness, stability of moisture labile materials, and its capable of producing consistent dissolution profiles in tablets . However, it requires the incorporation of excipients with appropriate functionality to attain desired formulation goals.…”

Section: Introductionmentioning

confidence: 99%

Impact of Thermal and Chemical Modifications on the Compression and Release Properties of Bambara Nut Starches in Directly Compressed Tablet Formulations

2018

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Chemical and physical modifications can be used to impart desired properties to native starches. The present study investigates the compaction, mechanical, and release properties of thermal and chemically modified starches from Bambara nuts in ibuprofen tablet formulations. The native starches extracted from Bambara nuts are modified to obtain the pregelatinized and carboxymethylated forms. Heckel, Kawakita, and Gurnham equations are used to analyze the compressional properties of the formulations. The crushing strength of the tablets are assessed while disintegration and dissolution times are used to evaluate the drug release properties of the tablets. Pregelatinized starch-containing formulations exhibited faster onset and carboxymethylated starch had a higher amount of plastic deformation during compression than formulations incorporating the native starch. An increase in the particle size of Bambara starch had a significant effect on the densification of the starches during die filling, particle rearrangement, fragmentation propensity, and elastic/plastic deformation. The crushing strength and dissolution times of the tablets improves on starch modification. Tablets from the pregelatinized starch had longer disintegration time when compared with carboxymethylated and native Bambara starches. Formulations incorporating carboxymethylated starch had the shortest disintegration time, longest dissolution, and highest crushing strength values. The compressional, mechanical, and release properties of directly compressed ibuprofen tablet formulations are improved with the incorporation of the modified starches. Carboxymethylation and pregelatinization may be used to develop native starches as pharmaceutical excipients in specific formulations.

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Compression, Mechanical and Release Properties of Chloroquine Phosphate Tablets containing corn and Trifoliate Yam Starches as Binders

Cited by 25 publications

References 12 publications

Native and Modified Digitaria exilis Starch Nanoparticles as a Carrier System for the Controlled Release of Naproxen

Native and Modified Digitaria exilis Starch Nanoparticles as a Carrier System for the Controlled Release of Naproxen

Evaluation of Cedrela gum as a binder and bioadhesive component in ibuprofen tablet formulations

Impact of Thermal and Chemical Modifications on the Compression and Release Properties of Bambara Nut Starches in Directly Compressed Tablet Formulations

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