Evaluation of Cedrela gum as a binder and bioadhesive component in ibuprofen tablet formulations

Abstract

The compressional, mechanical and bioadhesive properties of tablet formulations incorporating a new gum obtained from the incised trunk of the Cedrela odorata tree were evaluated and compared with those containing hydroxypropylmethylcellulose (HPMC). Compressional properties were evaluated using Hausner's ratio, Carr's Index, the angle of repose, and Heckel, Kawakita and Gurnham plots. Ibuprofen tablets were prepared using the wet granulation method. Bioadhesive studies were carried out using the rotating cylinder method in either phosphate buffer pH 6.8 or 0.1 M hydrochloric acid media. The gum is a low viscosity polymer (48 cPs), and Fourier transform infrared spectroscopy revealed the presence of a hydroxyl group. P y and P k values, which are measures of plasticity, showed the gum to be significantly (p<0.05) more plastic than HPMC, and plasticity increased with polymer concentration. All tablet formulations were non-friable (<1.0%), and the formulations containing the gum had a higher crushing strength (130.95 N) than those containing HPMC (117.85 N) at 2.0% w/w binder. Formulations incorporating the gum were non-disintegrating and had a significantly longer drug release time than those containing HPMC. At the highest binder concentration, Cedrela gum formulations adhered to incised pig ileum longer than those containing HPMC. Cedrela gum exhibited better compressive, flow and binding properties than HPMC and is suitable as a bioadhesive and for sustained release of drugs.Uniterms: Cedrela gum/evaluation/compression properties. Cedrela gum/bioadhesive component. Tablet formulations. Hydroxypropylmethylcellulose. Ibuprofen tablets/bioadhesive studies. Bioadhesion.Propriedades de compressão, mecânicas e de formulações de comprimidos bioadesivos, que incorporam nova goma de mascar obtidas a partir de incisão de tronco da árvore de Cedrela odorata, foram avaliadas e comparadas com aquelas contendo hidroxipropilmetilcelulose (HPMC). Propriedades de compressão foram avaliadas usando a razão de Hausner, índice de Carr, ângulo de repouso e os gráficos de Heckel, Kawakita e Gurnham. Prepararam-se comprimidos de ibuprofeno utilizando o método de granulação a úmido. Realizaram-se estudos de bioadesividade utilizando o método de cilindro rotativo em tampão fosfato pH 6,8, ou meio ácido com 0,1 M de ácido clorídrico. A goma é um polímero de baixa viscosidade (48 cPs) e a espectroscopia no infravermelho por Transformada de Fourier (FTIR) revelou a presença de um grupo hidroxila. Valores de Py e Pk, que são medidas de plasticidade, mostraram que a goma é significativamente (p <0,05) mais plástica do que HPMC e que a plasticidade aumenta com a concentração de polímero. Todas as formulações de comprimidos mostraram-se não-friáveis (<1,0%) e aquelas contendo a goma apresentaram maior resistência ao esmagamento (130.95N) do que aquelas contendo HPMC (117.85N) em 2,0% (p/p) do ligante. As formulações que incorporaram a goma eram não-desintegrantes e apesentaram tempo de liberação significativamente maior do que aquelas contend...

Native and microwave-modified Terminalia mantaly gums as sustained-release and bioadhesive excipients in naproxen matrix tablet formulations

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Effect of thermal and chemical modifications on the mechanical and release properties of paracetamol tablet formulations containing corn, cassava and sweet potato starches as filler-binders

“…Increase in D t as the concentration of starch in the formulations increased may be related to the formation of a mucilaginous viscous barrier in the presence of water, thus inhibiting disintegration. The thickness of the barrier is directly related to the concentration of the starch binder [23] .…”

Evaluation of two novel plant gums for bioadhesive microsphere and sustained-release formulations of metformin hydrochloride

“…There was an increase in peak detachment force with the increasing concentration of polymer in all the formulations, which agrees with the previous report that an increasing concentration of bioadhesive polymer is capable of increasing the binding potential. 5 The polymers, being hydrophilic, absorb water, swell and these enhance mucoadhesion with the mucosal layer. The swelling led to formation of bonds and a spatial network between the mucous membrane and the adhesive polymer in the microspheres.…”

“…4 Previous works showed cedrela gum to have mucoadhesive properties. 5 Enterolobium gum, produced by the Enterolobium cyclocarpus tree family Mimosoideae of the Leguminosae, is commonly known as the guanacaste or elephant-ear tree. It is a species of flowering tree, native to Central America and now widely distributed throughout the tropics where it is planted mainly as a roadside or garden tree.…”

“…HPMC was used in this study due to its reported significant adhesive properties in tablet dosage forms. 5,13 Natural mucoadhesive substances considerably swell in water and form a gelatinous mass.…”