Compression of enteric-coated pellets to disintegrating tablets

Beckert, Thomas E.; Lehmann, K.; Schmidt, Peter

doi:10.1016/s0378-5173(96)04631-5

Cited by 67 publications

(22 citation statements)

References 21 publications

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“…using powders and granules of various excipients along with disintegrants (Beckert et al, 1996(Beckert et al, , 1998 higher porosity and compactibility (Habib et al, 2002).…”

mentioning

confidence: 99%

Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules

Mehta

Beer

Remon

et al. 2012

International Journal of Pharmaceutics

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25A design of experiments (DOE) approach (2-level full factorial design) was used to investigate the effect of several formulation and process variables on the properties of fast disintegrating tablets comprising starch-based pellets and excipient granules and to optimize and validate the design space. The percentage of starch pellets (30-50% w/w), type of disintegrants (Ac-di-sol, Explotab, Polyplasdone), percentage of external disintegrant (4-8% w/w) and 30 compression force (5-15 kN) were the evaluated factors (24 runs + 9 centre points = 33 experiments), while tablet hardness, friability and disintegration time were the studied tablet properties (responses).Starch pellets were prepared by extrusion-spheronisation. Excipient granules containing microcrystalline cellulose, lactose, internal disintegrant (8%) and polyvinylpyrrolidone K-30 35(4%) were prepared by wet granulation. Pellets, granules (700-1000 µm) and external disintegrant were mixed and compressed into oblong tablets (17.1 mm long, 8.2 mm wide).Evaluation of the effects calculated from the DOE results showed that a lower concentration of starch pellets and higher compression force were required to yield tablets with a high hardness, a low friability (<1%) and short disintegration time (<3 min). Polyplasdone granules had the 40 lowest porosity and friability which was reflected in the DOE study, where the Polyplasdonecontaining tablets were harder, less friable and disintegrated faster compared to Ac-di-sol and Explotab-containing tablets. Monte carlo simulations at the optimal factor settings (30% starch pellets, 4% Polyplasdone and 10 kN compression force) indicated that a robust system was formed as the probability to exceed the limits was low for all responses. Validation of the design 45 3 space (at optimal settings) showed that the results predicted via the DOE models correlated well with the observed experimental data. KEYWORDS

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“…using powders and granules of various excipients along with disintegrants (Beckert et al, 1996(Beckert et al, , 1998 higher porosity and compactibility (Habib et al, 2002).…”

mentioning

confidence: 99%

Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules

Mehta

Beer

Remon

et al. 2012

International Journal of Pharmaceutics

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“…[24][25][26][27][28][29] Beckert et al 30) investigated the influence of compression force, excipients, pellet content, and coating formulation on the dissolved percentage in the acid stage and the disintegration time of rapidly disintegrating tablets containing enteric-coated pellets. They concluded that the dissolved percentage in the acid stage increased with the increasing content of enteric-coated pellets.…”

Section: Resultsmentioning

confidence: 99%

Formulation Study for Lansoprazole Fast-disintegrating Tablet. III. Design of Rapidly Disintegrating Tablets

et al. 2003

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“…Ludipress has several advantages such as the low degree of hygroscopicity, good flowability, tablet hardness independent of machine speed [32]. The ratio of drug loaded pellets to tableting excipients was an important parameter optimized to compress the pellets into tablet form [33]. fig.…”

Section: Development and Characterization Of Mups Tablet From Pantoprmentioning

confidence: 99%

Multiple Unit Pellet System (Mups) Based Fast Disintegrating Delayed-Release Tablets for Pantoprazole Delivery

Patel

Patel²,

Joshi

2018

Int J Pharm Pharm Sci

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Objective: The rationale for the study was to develop multiple unit pellet system (MUPS) of delayed release pantoprazole with desired physical properties and unaltered drug release profile from pellets even after compression into a fast disintegrating tablet. Methods:In the presented study, delayed release pellets of pantoprazole were developed by two methods, i.e. extrusion-spheronization and drug layering techniques, coated using enteric polymer and subsequently compressed in to tablet. In drug layering technique, pantoprazole was loaded on Celphere ® 102 (microcrystalline cellulose spheres) as well as on Suglet ® (sugar spheres) in fluid bed processor. Acid resistant polymer Eudragit ND 30D was subsequently coated on each type of drug loaded pellets. Suitable tableting excipients were prepared such as soft pellets, Ceolus ® (fibrous grade of microcrystalline cellulose) granules, Ludipress ® (compressible lactose composition), Avicel ® PH 200 and different combination of them. Various factors like property of pellets to be compressed, coating level, the composition of tableting excipient and ratio of drug-loaded pellets to tableting excipients were identified and optimized.Results: MUPS with delayed releasing pellets of pantoprazole proved to provide sufficient hardness, rapid disintegration property, and unaltered release profile after compression. Delayed release pantoprazole pellets prepared by drug layering on celphere ® 102 followed by coating with Eudragit ® NE 30D showed better compressibility to withstand the drug release properties. The combination of Ceolus ® granules and Ludipress (in 1:1 ratio) was found to be suitable tableting excipient that helped compression of pellets without rupturing polymeric coat. Pellets to excipients ratio at 1:3 was found optimum. Conclusion:Compaction behaviour of pantoprazole delayed-release pellets without loss of original delayed release profile was achieved by formulating as MUPS based tablet of pantoprazole delayed release pellets using celephere ® 102 was developed which was found suitable for desired release profile and physical properties.

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Compression of enteric-coated pellets to disintegrating tablets

Cited by 67 publications

References 21 publications

Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules

Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules

Formulation Study for Lansoprazole Fast-disintegrating Tablet. III. Design of Rapidly Disintegrating Tablets

Multiple Unit Pellet System (Mups) Based Fast Disintegrating Delayed-Release Tablets for Pantoprazole Delivery

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