Variation of environmental conditions exhibits various modes of failure of asphalt concrete pavement. Under cold environment, the flexible pavement experience cracking and disintegration, while under hot environment, the pavement practices rutting. Both environmental conditions can enhance the fatigue life of the flexible pavement. In the present work, the role of the change in the dissipated energy, and flexural stiffness of asphalt concrete on its fatigue life under environmental influence have been investigated. Asphalt concrete mixtures were prepared with its optimum asphalt binder requirements, and then compacted into a slab mold by laboratory roller to a target density. Beam specimens were obtained from the prepared slab samples and tested for fatigue life using three levels of constant strain of (750, 400, and 250) microstrain under dynamic flexural stresses. The specimens were tested at (5, 20, and 30) ℃ environment levels. It was noticed that specimens practicing cold environment exhibit shorter fatigue life as compared with those tested at hot environment. However, the flexural stiffness of the beam specimens decline as the testing temperature rises. Such behavior was further supported with the variation in the dissipated energy among testing environment. It was concluded that higher testing environment declines the flexural stiffness, increases the fatigue life, and changes the mode of failure of asphalt concrete from brittle to plastic mode.