Compressive behaviour of gyroid lattice structures for human cancellous bone implant applications

Yáñez, Alejandro J.; Herrera, Ana María Trejos; Fuentes, Óscar Martel; Monopoli, Donato; Afonso, H.

doi:10.1016/j.msec.2016.06.016

Cited by 129 publications

(77 citation statements)

References 28 publications

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“…Since hydrogels are mechanically fragile, to improve its retention at the application site, the hydrogel was loaded in a 3D printed gyroid PCL and post-crosslinked. Furthermore, a gyroid structure is characterized as having a minimal surface area and architectural as well as mechanical characteristics similar to trabecular bone [ 34 , 35 , 36 ]. The highest amount of hydrogel loading capacity in the gyroid scaffolds could be related to the larger pore size and minimal surface area as compared to other scaffold designs [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

A Bioactive Hydrogel and 3D Printed Polycaprolactone System for Bone Tissue Engineering

Hernandez

Kumar

Joddar

2017

Gels

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In this study, a hybrid system consisting of 3D printed polycaprolactone (PCL) filled with hydrogel was developed as an application for reconstruction of long bone defects, which are innately difficult to repair due to large missing segments of bone. A 3D printed gyroid scaffold of PCL allowed a larger amount of hydrogel to be loaded within the scaffolds as compared to 3D printed mesh and honeycomb scaffolds of similar volumes and strut thicknesses. The hydrogel was a mixture of alginate, gelatin, and nano-hydroxyapatite, infiltrated with human mesenchymal stem cells (hMSC) to enhance the osteoconductivity and biocompatibility of the system. Adhesion and viability of hMSC in the PCL/hydrogel system confirmed its cytocompatibility. Biomineralization tests in simulated body fluid (SBF) showed the nucleation and growth of apatite crystals, which confirmed the bioactivity of the PCL/hydrogel system. Moreover, dissolution studies, in SBF revealed a sustained dissolution of the hydrogel with time. Overall, the present study provides a new approach in bone tissue engineering to repair bone defects with a bioactive hybrid system consisting of a polymeric scaffold, hydrogel, and hMSC.

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Section: Discussionmentioning

confidence: 99%

A Bioactive Hydrogel and 3D Printed Polycaprolactone System for Bone Tissue Engineering

Hernandez

Kumar

Joddar

2017

Gels

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“…Both gyroid structures have shown a good strength-to-weight ratio for a certain angle of strut orientation and specific strength and stiffness [ 135 , 136 ]. Yanez et al [ 31 , 135 ] investigated the mechanical properties of a normal gyroid scaffold and a severally deformed gyroid scaffold with different angels (19°, 21.5°, 26°, 35°, 55°, 64° and 68.5°) in terms of compression tests, torsion tests and finite element analysis and reported that both the elastic modulus and compressive strength of the gyroid structures were reversely proportional to the strut angle at the axial direction. As the pores of normal gyroid exhibit a spherical shape, the structure possesses higher homogeneity in mechanical performance than that of the deformed gyroid.…”

Section: Triply Periodic Minimal Surface (Tpms) Structuresmentioning

confidence: 99%

Additive manufacturing technology for porous metal implant applications and triple minimal surface structures: A review

Ding

Wen

2019

Bioactive Materials

423

200

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Recently, the fabrication methods of orthopedic implants and devices have been greatly developed. Additive manufacturing technology allows the production of complex structures with bio-mimicry features, and has the potential to overcome the limitations of conventional fabrication methods. This review explores open-cellular structural design for porous metal implant applications, in relation to the mechanical properties, biocompatibility, and biodegradability. Several types of additive manufacturing techniques including selective laser sintering, selective laser melting, and electron beam melting, are discussed for different applications. Additive manufacturing through powder bed fusion shows great potential for the fabrication of high-quality porous metal implants. However, the powder bed fusion technique still faces two major challenges: it is high cost and time-consuming. In addition, triply periodic minimal surface (TPMS) structures are also analyzed in this paper, targeting the design of metal implants with an enhanced biomorphic environment.

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“…It was noted that stiffness decreased with the increase of porosity, which is desirable for reducing the stress shielding effect. Yánez et al [60] evaluated the compressive behavior of gyroid lattice structures for cancellous bone applications. The strut angle was found to be a critical factor that affected the compressive properties: as the strut angle decreased, the stiffness and compressive strength increased.…”

Section: Characterizationmentioning

confidence: 99%

Lattice Structures and Functionally Graded Materials Applications in Additive Manufacturing of Orthopedic Implants: A Review

Mahmoud

Elbestawi

2017

JMMP

201

117

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A major advantage of additive manufacturing (AM) technologies is the ability to print customized products, which makes these technologies well suited for the orthopedic implants industry. Another advantage is the design freedom provided by AM technologies to enhance the performance of orthopedic implants. This paper presents a state-of-the-art overview of the use of AM technologies to produce orthopedic implants from lattice structures and functionally graded materials. It discusses how both techniques can improve the implants' performance significantly, from a mechanical and biological point of view. The characterization of lattice structures and the most recent finite element analysis models are explored. Additionally, recent case studies that use functionally graded materials in biomedical implants are surveyed. Finally, this paper reviews the challenges faced by these two applications and suggests future research directions required to improve their use in orthopedic implants.

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Compressive behaviour of gyroid lattice structures for human cancellous bone implant applications

Cited by 129 publications

References 28 publications

A Bioactive Hydrogel and 3D Printed Polycaprolactone System for Bone Tissue Engineering

A Bioactive Hydrogel and 3D Printed Polycaprolactone System for Bone Tissue Engineering

Additive manufacturing technology for porous metal implant applications and triple minimal surface structures: A review

Lattice Structures and Functionally Graded Materials Applications in Additive Manufacturing of Orthopedic Implants: A Review

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