Compromised activity of natural killer cells in diffuse large b-cell lymphoma is related to lymphoma-induced modification of their surface receptor expression

Azoulay, Tehila; Slouzky, Ilana; Karmona, Michal; Filatov, Margarita; Hayun, Michal; Ofran, Yishai; Sarig, Galit; Ringelstein-Harlev, Shimrit

doi:10.1007/s00262-022-03284-4

Cited by 4 publications

(2 citation statements)

References 55 publications

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“…Our team is well-versed in the efficacy and risks of ANK therapy. Patients and their families have previously requested ANK therapy, which is associated with fewer side effects than chemotherapy, can be received on an outpatient basis, and is expected to gain momentum as an effective treatment strategy[ 16 - 18 ].…”

Section: Discussionmentioning

confidence: 99%

Diffuse large B-cell lymphoma successfully treated with amplified natural killer therapy alone: A case report

Nagai,

Okubo

et al. 2023

World J Clin Cases

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Rehabilitation of lower limb amputation in developing countries is quite challenging. Though there are basic to highly advanced prostheses available in India, the set-up is still facing difficulties in developing countries. Prosthetic management is difficult due to lack of availability of prostheses and reduced affordability among low income populations. In this review we highlighted the lower limb amputation and prosthetic rehabilitation status in India. Currently, India is advancing well in the rehabilitation field, but further studies are required to provide more evidence and recommendation.

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Section: Discussionmentioning

confidence: 99%

Diffuse large B-cell lymphoma successfully treated with amplified natural killer therapy alone: A case report

Nagai,

Okubo

et al. 2023

World J Clin Cases

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“…Patients with acute myeloid leukaemia (AML) present with higher NKG2A expression on peripheral NK cells compared to healthy controls and NKG2A expression correlates with failure to achieve remission [28,29]. In addition, compared to healthy controls, high expression of NKG2A is evident on defective NK cells isolated from patients with DLBCL [30]. Therapeutic strategies aimed at disrupting the NKG2A:HLA-E axis therefore have high potential for overcoming cancer mediated immune suppression in various solid and haematological cancer settings.…”

Section: Nkg2a and Control Of Nk Cell Activationmentioning

confidence: 99%

Disruption of the NKG2A:HLA-E Immune Checkpoint Axis to Enhance NK Cell Activation against Cancer

et al. 2022

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Ligation of the inhibitory receptor NKG2A by its ligand HLA-E negatively regulates the activation of natural killer (NK) cells, as well as subsets of CD8+ T cells and innate T cell populations. NKG2A has recently become a novel immune checkpoint target for the treatment of cancer and direct antibody mediated blockade of NKG2A function is currently under assessment in two phase 3 clinical trials. In addition to direct targeting, the NKG2A:HLA-E axis can also be disrupted indirectly via multiple different targeted cancer agents that were not previously recognised to possess immunomodulatory properties. Increased understanding of immune cell modulation by targeted cancer therapies will allow for the design of rational and more efficacious drug combination strategies to improve cancer patient outcomes. In this review, we summarise and discuss the various strategies currently in development which either directly or indirectly disrupt the NKG2A:HLA-E interaction to enhance NK cell activation against cancer.

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Romanowsky staining: history, recent advances and future prospects from a chemistry perspective

Kalinin,

Padnya,

Stoikov

2023

Biotechnic & Histochemistry

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Compromised activity of natural killer cells in diffuse large b-cell lymphoma is related to lymphoma-induced modification of their surface receptor expression

Cited by 4 publications

References 55 publications

Diffuse large B-cell lymphoma successfully treated with amplified natural killer therapy alone: A case report

Diffuse large B-cell lymphoma successfully treated with amplified natural killer therapy alone: A case report

Disruption of the NKG2A:HLA-E Immune Checkpoint Axis to Enhance NK Cell Activation against Cancer

Romanowsky staining: history, recent advances and future prospects from a chemistry perspective

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