Compromiso neurológico grave por déficit de vitamina B12 en lactantes hijos de madres veganas y vegetarianas

Aguirre, Juan A; Donato, María L; Buscio, Mariela; Ceballos, Verónica; Armeno, Marisa; Aizpurúa, Luciana; Arpí, Lucrecia

doi:10.5546/aap.2019.e420

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Diversas instituciones científicas (como la Academia de Nutrición y Dietética de los Estados Unidos y la Sociedad Argentina de Nutrición) encontraron evidencias suficientes para afirmar que las dietas vegetarianas bien planificadas -incluso las estrictas que no contienen carnes, huevos ni lácteos-son saludables, nutricionalmente adecuadas y apropiadas para cualquier etapa de la vida, incluyendo embarazo, lactancia, infancia, niñez, adolescencia, adultez y vejez e incluso para atletas (Gallo et al 2015;Melina et al 2016;Arrieta 2017). Sin embargo, es importante resaltar la importancia que tiene la planificación adecuada de las dietas con el asesoramiento de un profesional de la nutrición -recomendación extendida a toda la población debido a la baja calidad dietaria general-principalmente para evitar las posibles deficiencias nutricionales, especialmente de vitamina B 12 (cuyo déficit puede causar anemia y trastornos neurológicos [Aguirre et al 2019]). La ingesta de un suplemento de vitamina B 12 es suficiente para asegurar la ingesta adecuada de este vital nutriente.…”

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Dietas saludables y sustentables, ¿Son posibles en la Argentina?

2021

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Section: ₁₅₆ Em A�� unclassified

Dietas saludables y sustentables, ¿Son posibles en la Argentina?

2021

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Intelligent MRI diagnosis of neurological alterations in infants from 4 to 12 months

Calderon‐Uribe,

Morales‐Hernandez,

De Leo‐Jimenez

et al. 2024

Int J Imaging Syst Tech

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Magnetic resonance imaging is an essential tool for the identification of neurological problems since it provides relevant information on brain development. The aim of the present work was the detection of neurological alterations in newborns from 4 to 12 months of age by segmentation and analysis of lateral ventricles in magnetic resonance images. For this purpose, an automated deep approach based on U‐net is proposed to segment the cerebral ventricles of the newborn. Subsequently, for these regions, features were extracted based on the patient's clinical history and on the shape (area, roundness, normalized central moment, among others) and pixel intensity (mean gray value, contrast level, among others). Once the features were extracted, different types of intelligent models (Logistic Regression, k‐Nearest Neighbors (kNN), and a Convolutional Neural Network) were assessed to detect the presence of neurological alterations. The segmentation phase of the system was tested on 50 patients and the classification phase on 28 patients (11 healthy, 17 with neurological changes). The results show a DICE similarity coefficient of 0.89 and a volume ratio of 1.05 for the segmentation stage and an accuracy of 98%, precision of 100%, sensitivity of 92%, and specificity of 100% for the classification stage using kNN. The last one proved to be the most computationally feasible model, due to the time required for training and inference (0.36 s and 35.2e‐4 s, respectively), as well as the consumption of computational resources (0.1 GB RAM CPU). In conclusion, it is possible to detect neurological alterations in newborns aged 4 to 12 months by segmenting and classifying the lateral ventricles in magnetic resonance images, using image processing techniques, the U‐net, as well as the kNN algorithm. This proposed methodology could play an important role in the early diagnosis and treatment of neurological disorders.

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A Preventable Cause of Hypotonia in Infants: Case Report of Two Infants with Vitamin B12 Deficiency

Akhrif¹,

Saghir

Kmari

et al. 2021

Asp J Pediatrics Child Health

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Introduction: Innate deficits in the metabolism or transport of vitamin B12 are exceptional. The main cause of vitamin B12 deficiency in infants is secondary to maternal deficiency. Maternal deficiency can have a vegan diet, low socio-economic level (developing countries) and a high level of development with a poor diet) or digestive pathologies responsible for a lack of absorption. The clinical signs are not very specific (developmental delay, pallor, hypotonia, vomiting and diarrhoea), which explains the frequent delay in diagnosis. The pathophysiology of the neurological damage, which is still uncertain, is thought to be secondary to a defect in myelination with altered nerve conduction and cortical atrophy. The aim of this work is to underline the importance of raising awareness of vitamin B12 deficiency in order to avoid its profound neurological repercussions, especially as substitution treatment allows an improvement or a reversibility of the neurological damage and raises the question of the possibility of screening new-borns. Materials and Methods: We report the case of two infants aged 6 months and 10 months with hypotonia and psychomotor regression from an early age, whose biological examination revealed pancytopenia with a collapsed vitamin B12 level in both infants and both mothers.

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Compromiso neurológico grave por déficit de vitamina B12 en lactantes hijos de madres veganas y vegetarianas

Cited by 3 publications

References 10 publications

Dietas saludables y sustentables, ¿Son posibles en la Argentina?

Dietas saludables y sustentables, ¿Son posibles en la Argentina?

Intelligent MRI diagnosis of neurological alterations in infants from 4 to 12 months

A Preventable Cause of Hypotonia in Infants: Case Report of Two Infants with Vitamin B12 Deficiency

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