Computational and experimental investigation of flow and particle settling in a roller bottle bioreactor

Muzzio, Fernando J.; Unger, D. R.; Liu, M.; Bramble, Joye L.; Searles, James A.; Fahnestock, P.

doi:10.1002/(sici)1097-0290(19990420)63:2<185::aid-bit7>3.0.co;2-c

Cited by 9 publications

(2 citation statements)

References 23 publications

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“…As seen in Table 1, CFD can be used to study the effects of various parameters on performance of the various reactors of different designs. The parameters examined include tank dimensions, agitator speed, and liquid height on hydrodynamic properties like velocity patterns, gas hold up, volume fractions, mass‐transfer coefficient, power dissipation, and shear stress 8–18…”

Section: Microbial Fermentation And/or Mammalian Cell Culturementioning

confidence: 99%

Review of Computational fluid dynamics applications in biotechnology processes

Sharma

Malhotra

Rathore

2011

Biotechnology Progress

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Computational fluid dynamics (CFD) is well established as a tool of choice for solving problems that involve one or more of the following phenomena: flow of fluids, heat transfer,mass transfer, and chemical reaction. Unit operations that are commonly utilized in biotechnology processes are often complex and as such would greatly benefit from application of CFD. The thirst for deeper process and product understanding that has arisen out of initiatives such as quality by design provides further impetus toward usefulness of CFD for problems that may otherwise require extensive experimentation. Not surprisingly, there has been increasing interest in applying CFD toward a variety of applications in biotechnology processing in the last decade. In this article, we will review applications in the major unit operations involved with processing of biotechnology products. These include fermentation,centrifugation, chromatography, ultrafiltration, microfiltration, and freeze drying. We feel that the future applications of CFD in biotechnology processing will focus on establishing CFD as a tool of choice for providing process understanding that can be then used to guide more efficient and effective experimentation. This article puts special emphasis on the work done in the last 10 years.

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Section: Microbial Fermentation And/or Mammalian Cell Culturementioning

confidence: 99%

Review of Computational fluid dynamics applications in biotechnology processes

Sharma

Malhotra

Rathore

2011

Biotechnology Progress

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“…Due to the low solubilities and densities of these organic chemicals, in the controlled roller bioreactor (bioreactor without beads or baffl es), the solid particles fl oated on the media surface. The phenomenon of particle separation in rotating bioreactors has been modelled both experimentally and theoretically by Muzzio et al (1999).…”

Section: Micro-organism Medium Chemicals and Analysesmentioning

confidence: 99%

Mass Transfer and Bioremediation of Naphthalene and Methyl Naphthalenes in Baffled and Bead Mill Bioreactors

Nemati

Hill

et al. 2006

Can J Chem Eng

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On a étudié le transfert de masse et le traitement biologique à action curative de naphtalène, méthylenaphtalène-2 et diméthylnaphtalène-1,5 dans un bioréacteur rotatif modifi é avec ajout de chicanes et de billes. Les taux de transfert de masse de ces particules organiques de faible solubilité qui se dissolvent dans l'eau (en se basant sur le volume de travail du bioréacteur) sont plus élevées dans le bioréacteur qui incorporent les billes et les chicanes, le coeffi cient de transfert de masse global (KLa) atteignant jusqu'à 25 h-1. D'après sa capacité à contenir le plus grand volume de milieux pollués, le bioreacteur à chicanes est considéré comme la conception de bioréacteur à rouleaux optimum. Avec Pseudomonas putida, le taux de traitement biologique à action curative du naphatlène atteint 61 mg/l-h dans le réacteur et en utilisant des substrats mélangés, le taux de traitement biologique à action curative du méthylnaphtalène-2 atteint 30 mg/l-h. Les vitesses de dissolution pour les particules hydrophobes dans les milieux de culture durant le procédé de traitement biologique à action curative sont jusqu'à quatre fois plus élevées que les vitesses de transfert de masse dans les contrôles abiotiques, ce qui est probablement dû à la production de biosurfactants par P. putida.

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Viral Vaccine Production in Cell Culture

Auniņš

2000

Encyclopedia of Cell Technology

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Computational and experimental investigation of flow and particle settling in a roller bottle bioreactor

Cited by 9 publications

References 23 publications

Review of Computational fluid dynamics applications in biotechnology processes

Review of Computational fluid dynamics applications in biotechnology processes

Mass Transfer and Bioremediation of Naphthalene and Methyl Naphthalenes in Baffled and Bead Mill Bioreactors

Viral Vaccine Production in Cell Culture

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