Computational Fluid Dynamic Accuracy in Mimicking Changes in Blood Hemodynamics in Patients with Acute Type IIIb Aortic Dissection Treated with TEVAR

Abstract

Background: We aimed to verify the accuracy of the Computational Fluid Dynamics (CFD) algorithm for blood flow reconstruction for type IIIb aortic dissection (TBAD) before and after thoracic endovascular aortic repair (TEVAR). Methods: We made 3D models of the aorta and its branches using pre- and post-operative CT data from five patients treated for TBAD. The CFD technique was used to quantify the displacement forces acting on the aortic wall in the areas of endograft, mass flow rate/velocity and wall shear stress (WSS). Calculated results were verified with ultrasonography (USG-Doppler) data. Results: CFD results indicated that the TEVAR procedure caused a 7-fold improvement in overall blood flow through the aorta (p = 0.0001), which is in line with USG-Doppler data. A comparison of CFD results and USG-Doppler data indicated no significant change in blood flow through the analysed arteries. CFD also showed a significant increase in flow rate for thoracic trunk and renal arteries, which was in accordance with USG-Doppler data (accuracy 90% and 99.9%). Moreover, we observed a significant decrease in WSS values within the whole aorta after TEVAR compared to pre-TEVAR (1.34 ± 0.20 Pa vs. 3.80 ± 0.59 Pa, respectively, p = 0.0001). This decrease was shown by a significant reduction in WSS and WSS contours in the thoracic aorta (from 3.10 ± 0.27 Pa to 1.34 ± 0.11Pa, p = 0.043) and renal arteries (from 4.40 ± 0.25 Pa to 1.50 ± 0.22 Pa p = 0.043). Conclusions: Post-operative remodelling of the aorta after TEVAR for TBAD improved hemodynamic patterns reflected by flow, velocity and WSS with an accuracy of 99%.

Shape and Enhancement Analysis as a Useful Tool for the Presentation of Blood Hemodynamic Properties in the Area of Aortic Dissection

“…: RNN/126/07/KE). Inclusion criteria comprise acute type IIIb aortic dissection that started proximal to the left subclavian artery and involved the renal arteries in each of the analyzed cases [32,33] (Table 1). Table 1.…”

“…The average cross-section for the common duct was equal to 1655 32. ± 258.03 mm and 1509.84 ± 244.77 mm for D F and D Hy , respectively.…”

Spatial Configuration of Abdominal Aortic Aneurysm Analysis as a Useful Tool for the Estimation of Stent-Graft Migration

“…Furthermore, blood density had a set value which enabled us to treat it as incompressible liquid (ρ = const). The blood velocity profiles for each of analyzed patients were obtained from the USG-Doppler examination (GE Vivid 7, GE Healthcare, Fairfield, CT, USA) [ 36 , 37 ]. Moreover, to standardize the 3D models of AAA and stent-grafts reference velocity profiles, flat and sharp, were applied ( Figure 1 ) [ 38 ].…”

Hazards associated with municipal waste storage. Vol. I

“…The leachate samples for chromatographic tests were extracted with dichloromethane (10 cm 3 dichloromethane /200 cm 3 sample) by hand shaking for 5 min [28]. After extraction, the organic layer was separated and the samples were extracted again with dichloromethane (10 cm 3 dichloromethane /200 cm 3 sample) [29][30][31]. Due to the formation of emulsions, the separation of the aqueous and organic phase was slow, centrifugation was carried out (2,500 x g, 10 min) to fully separate the phases [32][33][34][35].…”