Computational modeling of vascular growth in patient-specific pulmonary arterial patch reconstructions

Lashkarinia, S Samaneh; Çoban, Gürsan; Kose, Banu; Salihoğlu, Ece; Pekkan, Kerem

doi:10.1016/j.jbiomech.2021.110274

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…Patch design has a significant impact on the repair of the defect, including the haemodynamics of the blood vessel, and contributes to long-term outcomes [19]. Nonetheless, many surgeons still subjectively design the patch intraoperatively based on previous experience and intraoperative assessment.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it can be used to model and study the effects of a patch on the native tissue including yielding important mechanical information (e.g., stress and strain). For example, one of the discussed studies used FEA software to specifically assess the effects of patch properties on vascular remodelling [19]. In this study, FEBio software was utilised, providing a rich library of plugins that can perform various simulations [37].…”

Section: Discussionmentioning

confidence: 99%

“…Another advantage of computational modelling is that it can also help simulate longterm outcomes of patch augmentation. The same group [19] used another simulation to predict the long-term outcomes of patch augmentation of the pulmonary arteries; in particular, they looked into how the presence of the patch affects the growth of the arteries up to 17 years after surgery. Simulations showed the proximal growth of the vessel and increased stiffness at the corners of the patch as well as at the original stenotic region.…”

Section: Pulmonary Arteriesmentioning

confidence: 99%

See 2 more Smart Citations

Surgical Patching in Congenital Heart Disease: The Role of Imaging and Modelling

Aljassam,

Caputo,

Biglino

2023

Life

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In congenital heart disease, patches are not tailored to patient-specific anatomies, leading to shape mismatch with likely functional implications. The design of patches through imaging and modelling may be beneficial, as it could improve clinical outcomes and reduce the costs associated with redo procedures. Whilst attention has been paid to the material of the patches used in congenital surgery, this review outlines the current knowledge on this subject and isolated experimental work that uses modelling and imaging-derived information (including 3D printing) to inform the design of the surgical patch.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Pulmonary Arteriesmentioning

confidence: 99%

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Surgical Patching in Congenital Heart Disease: The Role of Imaging and Modelling

Aljassam,

Caputo,

Biglino

2023

Life

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“…Further exploration of these materials in vascular grafts could facilitate more clinically relevant models and more insight into CVD mechanisms than is currently possible [ 11 , 72 ]. In addition, computational modeling before designing 3D vascular systems allows researchers to implement better design principles and forego much of the costly empirical experimentation usually needed to optimize these vascular systems [ 92 , 93 , 94 ]. Ultimately, combining all of these techniques can move the field forward in analyzing cardiovascular disease mechanisms in more depth and further testing potential future therapeutics or mitigation strategies that could help patients.…”

Section: Discussionmentioning

confidence: 99%

Engineering Smooth Muscle to Understand Extracellular Matrix Remodeling and Vascular Disease

Yarbrough

Gerecht

2022

Bioengineering

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The vascular smooth muscle is vital for regulating blood pressure and maintaining cardiovascular health, and the resident smooth muscle cells (SMCs) in blood vessel walls rely on specific mechanical and biochemical signals to carry out these functions. Any slight change in their surrounding environment causes swift changes in their phenotype and secretory profile, leading to changes in the structure and functionality of vessel walls that cause pathological conditions. To adequately treat vascular diseases, it is essential to understand how SMCs crosstalk with their surrounding extracellular matrix (ECM). Here, we summarize in vivo and traditional in vitro studies of pathological vessel wall remodeling due to the SMC phenotype and, conversely, the SMC behavior in response to key ECM properties. We then analyze how three-dimensional tissue engineering approaches provide opportunities to model SMCs’ response to specific stimuli in the human body. Additionally, we review how applying biomechanical forces and biochemical stimulation, such as pulsatile fluid flow and secreted factors from other cell types, allows us to study disease mechanisms. Overall, we propose that in vitro tissue engineering of human vascular smooth muscle can facilitate a better understanding of relevant cardiovascular diseases using high throughput experiments, thus potentially leading to therapeutics or treatments to be tested in the future.

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“…Clinically significant congenital heart defects (CHD) and vascular anomalies affect nearly 1% of live births [ 6 ]. One-third of these cases exhibit life-threatening complications without surgical interventions early in life [ 7 , 8 ]. For those requiring surgery, implantation of patch material to augment hypoplastic or replace absent structures is common [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Patch Materials for Pulmonary Artery Arterioplasty and Right Ventricular Outflow Tract Augmentation: A Review

et al. 2023

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Patch augmentation of the right ventricular outflow tract (RVOT) and pulmonary artery (PA) arterioplasty are relatively common procedures in the surgical treatment of patients with congenital heart disease. To date, several patch materials have been applied with no agreed upon clinical standard. Each patch type has unique performance characteristics, cost, and availability. There are limited data describing the various advantages and disadvantages of different patch materials. We performed a review of studies describing the clinical performance of various RVOT and PA patch materials and found a limited but growing body of literature. Short-term clinical performance has been reported for a multitude of patch types, but comparisons are limited by inconsistent study design and scarce histologic data. Standard clinical criteria for assessment of patch efficacy and criteria for intervention need to be applied across patch types. The field is progressing with improvements in outcomes due to newer patch technologies focused on reducing antigenicity and promoting neotissue formation which may have the ability to grow, remodel, and repair.

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Computational modeling of vascular growth in patient-specific pulmonary arterial patch reconstructions

Cited by 7 publications

References 32 publications

Surgical Patching in Congenital Heart Disease: The Role of Imaging and Modelling

Surgical Patching in Congenital Heart Disease: The Role of Imaging and Modelling

Engineering Smooth Muscle to Understand Extracellular Matrix Remodeling and Vascular Disease

Patch Materials for Pulmonary Artery Arterioplasty and Right Ventricular Outflow Tract Augmentation: A Review

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