Computational Parametric Study of the Axial and Radial Clearances in a Centrifugal Rotary Blood Pump

Rezaienia, Mohammad Amin; Paul, Gordon; Avital, Eldad; Rothman, Martin T.; Korakianitis, Theodosios

doi:10.1097/mat.0000000000000700

Cited by 12 publications

(7 citation statements)

References 36 publications

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“…Due to narrow clearance and a complex flow field resulting from the competing effect of centrifugal forces and pressure gradients, 17 clearance gaps are closely linked to blood damage and poor washout in blood pumps. 24 To assist old blood removal, the Corheart's secondary pathways are short with a 'straight line' shape and small pump size. A sufficient pressure gradient results in well-cleaned secondary pathways (Figure 7).…”

Section: Discussionmentioning

confidence: 99%

“…The Corheart has a good washout performance, which reduces the exposure time of blood to non‐physiological shear stress and artificial biomaterial surface. Due to narrow clearance and a complex flow field resulting from the competing effect of centrifugal forces and pressure gradients, 17 clearance gaps are closely linked to blood damage and poor washout in blood pumps 24 . To assist old blood removal, the Corheart's secondary pathways are short with a ‘straight line’ shape and small pump size.…”

Section: Discussionmentioning

confidence: 99%

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Preclinical evaluation of the fluid dynamics and hemocompatibility of the Corheart 6 left ventricular assist device

Fang

Yang²,

Wei

et al. 2023

Artificial Organs

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Background Corheart 6 (Corheart) is a newly developed magnetically levitated continuous‐flow left ventricular assist device currently undergoing multicenter clinical trials in China. Featuring a small size, minimal weight, and low power consumption, the Corheart aims to improve pump hemocompatibility, reduce adverse events, and enhance the quality of life of heart failure patients. Methods Computational simulations assessed flow field, shear stress, and washout, while in vitro and in vivo experiments were performed to further demonstrate hemocompatibility. Results Numerical results show that the flow path in the Corheart blood pump is well designed. There is no significantly high shear stress in the majority of the flow domain. Short secondary flow paths and small pump size (small priming volume) provide good washing (0.049 and 0.165 s to remove 55% and 95% old blood, respectively), allowing low hemolysis levels both in computational and in vitro hemolysis tests (in vitro hemolysis index ranges from 0.00092 ± 0.00006 g/100 L to 0.00134 ± 0.00019 g/100 L). Good hemocompatibility was further evidenced by ten 60‐day sheep implants tested with relatively low flow rates of 2.0 ± 0.2 L/min; the results showed no hemolysis or thrombosis. Conclusions Numerical and experimental results shed light on the fluid dynamics characteristics and hemocompatibility of the Corheart. It is believed that the Corheart will provide more promising possibilities for minimally invasive implantation techniques and for those patients with a small body surface area.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Preclinical evaluation of the fluid dynamics and hemocompatibility of the Corheart 6 left ventricular assist device

Fang

Yang²,

Wei

et al. 2023

Artificial Organs

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“…The mass and momentum equations for the mean flow are solved assuming incompressible flow, while the energy equation is not needed. These equations can be found in Pope (2001). The momentum equation incorporates a source term of inertial and body forces which corresponds to the additional term included by the MRF approach, calculated as described by Torregrosa et al (2019).…”

Section: Solver and Governing Equationsmentioning

confidence: 99%

CFD analysis of the HVAD’s hemodynamic performance and blood damage with insight into gap clearance

Gil

Navarro

Quintero

et al. 2022

Biomech Model Mechanobiol

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Mechanical circulatory support using ventricular assist devices has become commonplace in the treatment of patients suffering from advanced stages of heart failure. While blood damage generated by these devices has been evaluated in depth, their hemodynamic performance has been investigated much less. This work presents the analysis of the complete operating map of a left ventricular assist device, in terms of pressure head, power and efficiency. Further investigation into its hemocompatibility is included as well. To achieve these objectives, computational fluid dynamics simulations of a centrifugal blood pump with a wide-blade impeller were performed. Several conditions were considered by varying the rotational speed and volumetric flow rate. Regarding the device's hemocompatibility, blood damage was evaluated by means of the hemolysis index. By relating the hemocompatibility of the device to its hemodynamic performance, the results have demonstrated that highest hemolysis occurs at low flow rates, corresponding to operating conditions of low efficiency. Both performance and hemocompatibility are affected by the gap clearance. An innovative investigation into the influence of this design parameter has yielded decreased efficiencies and increased hemolysis as the gap clearance is reduced. As a further novelty, pump operating maps were non-dimensionalized to highlight the influence of Reynolds number, which allows their application to any working condition. The pump's operating range places it in the transitional regime between laminar and turbulent, leading to enhanced efficiency for the highest Reynolds number.

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“…SST k-ω model is a combination of the original k-ω model and standard k-ε model, switching to k-ε for the fully turbulent region and back to k-ω for near-wall and low Reynolds number flows. 59,164 Al-Azawy et al 165 compared six turbulence models for a pulsatile heart pump numerically, and the results were compared with experimental data. The RSM and SST k-ω model showed close agreement with reference data.…”

Section: Computational Techniquesmentioning

confidence: 99%

Analysis of rotary ventricular assist devices using CFD technique—A Review

Shukla

Mishra

Tewari

2022

Proceedings of the Institution of Mechanical Engineers, Part E:

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With the increasing focus on reducing deaths because of heart ailments, considerable emphasis has been directed toward the development of ventricular assist devices (VADs) that work on the principle of mechanical pumps for supporting an infirm heart. The VADs are used primarily to assist the left ventricle, but their use has been extended for supporting the right ventricle as well as for supporting both ventricles simultaneously. In this connection, computational fluid dynamics (CFD) has evolved as an efficient technique for the design, development, evaluation, and optimization of VADs, enabling the prediction of operational characteristics of VADs as well as detailed global and local flow characteristics for an extensive set of working environments even before the manufacture and use of the actual device. CFD techniques yield valuable insight into the VADs’ effectiveness that enhances its operational behavior and decreases the risk associated with the use of the device, and at the same time decreases the manufacturing lead time and costs associated with the device. CFD has been quite beneficially used for the performance evaluation of VADs, but it still needs further development as hemolysis and thrombosis models cannot be easily integrated with the flow simulations. This review article presents abrief introduction to rotary VADs with a primary focus on the current status of CFD analysis of axial VADs, which provide the most suitable methods for computational design and optimization of VADs. It also identifies critical knowledge gaps and outlines the hematological models and the difficulties encountered in integrating them into CFD. Finally, future work based on the current scenario is also included.

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Computational Parametric Study of the Axial and Radial Clearances in a Centrifugal Rotary Blood Pump

Cited by 12 publications

References 36 publications

Preclinical evaluation of the fluid dynamics and hemocompatibility of the Corheart 6 left ventricular assist device

Preclinical evaluation of the fluid dynamics and hemocompatibility of the Corheart 6 left ventricular assist device

CFD analysis of the HVAD’s hemodynamic performance and blood damage with insight into gap clearance

Analysis of rotary ventricular assist devices using CFD technique—A Review

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