Computational study of blood flow inside MCA aneurysm with/without endovascular coiling

Sadeh, Asal; Kazemi, Admin; Bahramkhoo, Moharam; Gerdroodbary, M. Barzegar

doi:10.1038/s41598-023-31522-x

Cited by 32 publications

(5 citation statements)

References 47 publications

(64 reference statements)

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“…The simulation of blood hemodynamics inside the MCA aneurysm with/without deformation by stent is done via computational fluid dynamics 29 – 32 . The transient form of Navier–stokes is used for the modeling of blood flow through the vessel and sac section 33 – 35 . The one-way FSI model is used to apply the impacts of the vessel interaction under the impacts of blood pressure 36 – 39 .…”

Section: Governing Methods and Applied Methodologymentioning

confidence: 99%

Analysis of the effects of stent-induced deformation on the hemodynamics of MCA aneurysms

Huang,

Zhou,

Duan

et al. 2023

Sci Rep

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The use of a stent to coil an aneurysm can alter the position of the main blood vessel and affect blood flow within the sac. This study thoroughly examines the impact of stent-induced changes on the risk of MCA aneurysm rupture. The research aims to assess the effects of coiling and vessel deformation on blood flow dynamics by comparing the OSI, WSS, and blood structure of two distinct MCA aneurysms to identify high-risk areas for hemorrhage. Computational fluid dynamics is used to model blood flow. The results indicate that aneurysm deformation does not always decrease the risk of rupture, and coiling is more effective in occluding blood flow than aneurysm deformation.

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Section: Governing Methods and Applied Methodologymentioning

confidence: 99%

Analysis of the effects of stent-induced deformation on the hemodynamics of MCA aneurysms

Huang,

Zhou,

Duan

et al. 2023

Sci Rep

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“…This difference is considered in balance and its slope should match the added body force in the momentum balance. The pressure jump disjunction is estimated as described in 66 , 71 , 72 : …”

Section: Mathematical Simulationmentioning

confidence: 99%

Computational fluid dynamics simulation of two-phase flow patterns in a serpentine microfluidic device

Amini

Ghazanfari

Heydari

et al. 2023

Sci Rep

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In the current research work, the flow behavior of a liquid–liquid extraction (LLE) process in a serpentine microchannel was analyzed. The simulation was performed using a 3D model and the results were found to be consistent with experimental data. The impact of the flow of chloroform and water on the flow model was also examined. The data indicate that once the aqua and organic phases flow rates are low and similar, a slug flow pattern is observed. However, as the overall flow rate raises, the slug flow transforms into parallel plug flow or droplet flow. An increment in the aqua flows while maintaining a constant organic phase flow rate results in a transition from slug flow to either droplet flow or plug flow. Finally, the patterns of flow rate in the serpentine micro-channel were characterized and depicted. The results of this study will provide valuable insights into the behavior of two-phase flow patterns in serpentine microfluidic devices. This information can be used to optimize the design of microfluidic devices for various applications. Furthermore, the study will demonstrate the applicability of CFD simulation in investigating the behavior of fluids in microfluidic devices, which can be a cost-effective and efficient alternative to experimental studies.

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“…Since aneurysm onset and development is strongly influenced by the local hemodynamic conditions [ 6 ], high-fidelity/three dimensional (3-D) computational fluid dynamics models [ 7 – 10 ] are generally employed for studying the interplay between blood flow and vascular growth/rupture. Blood flow simulations can be used in conjunction with morphological data to identify metrics for predicting aneurysm rupture [ 7 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms

Coccarelli,

Van Loon,

Chien

2024

Ann Biomed Eng

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Changes in cerebral blood flow are often associated with the initiation and development of different life-threatening medical conditions including aneurysm rupture and ischemic stroke. Nevertheless, it is not fully clear how haemodynamic changes in time across the Circle of Willis (CoW) are related with intracranial aneurysm (IA) growth. In this work, we introduced a novel reduced-order modelling strategy for the systematic quantification of longitudinal blood flow changes across the whole CoW in patients with stable and unstable/growing aneurysm. Magnetic Resonance Angiography (MRA) images were converted into one-dimensional (1-D) vessel networks through a semi-automated procedure, with a level of geometric reconstruction accuracy controlled by user-dependent parameters. The proposed pipeline was used to systematically analyse longitudinal haemodynamic changes in seven different clinical cases. Our preliminary simulation results indicate that growing aneurysms are not necessarily associated with significant changes in mean flow over time. A concise sensitivity analysis also shed light on which modelling aspects need to be further characterized to have reliable patient-specific predictions. This study poses the basis for investigating how time-dependent changes in the vasculature affect the haemodynamics across the whole CoW in patients with stable and growing aneurysms.

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Computational study of blood flow inside MCA aneurysm with/without endovascular coiling

Cited by 32 publications

References 47 publications

Analysis of the effects of stent-induced deformation on the hemodynamics of MCA aneurysms

Analysis of the effects of stent-induced deformation on the hemodynamics of MCA aneurysms

Computational fluid dynamics simulation of two-phase flow patterns in a serpentine microfluidic device

A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms

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