Computed tomographic appearance of urachal adenocarcinomas: review of 25 cases

Thali-Schwab, Cornelia M.; Woodward, Paula J.; Wagner, B.

doi:10.1007/s00330-004-2408-z

Cited by 80 publications

(53 citation statements)

References 9 publications

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“…Others also noted this correlation. 17 Approximately 50% of the urachal carcinomas in the current study that had been imaged preoperatively by computed tomography were solid, and %33% had macroscopic calcification. A cystic component was noted in %25% of cancers and, thus, should not be interpreted as indicative of a benign lesion.…”

Section: Discussionmentioning

confidence: 99%

Urachal carcinoma: Clinicopathologic features and long‐term outcomes of an aggressive malignancy

Ashley

Inman

Sebo

et al. 2006

Cancer

286

413

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Objective L‐dopa is the most widely used and most effective therapy for Parkinson disease (PD), but chronic treatment is associated with motor complications in the majority of patients. It has been hypothesized that providing more continuous delivery of L‐dopa to the brain would reduce the risk of motor complications, and that this might be accomplished by combining L‐dopa with entacapone, an inhibitor of catechol‐O‐methyltransferase, to extend its elimination half‐life. Methods We performed a prospective 134‐week double‐blind trial comparing the risk of developing dyskinesia in 747 PD patients randomized to initiate L‐dopa therapy with L‐dopa/carbidopa (LC) or L‐dopa/carbidopa/entacapone (LCE), administered 4× daily at 3.5‐hour intervals. The primary endpoint was time to onset of dyskinesia. Results In comparison to LC, patients receiving LCE had a shorter time to onset of dyskinesia (hazard ratio, 1.29; p = 0.04) and increased frequency at week 134 (42% vs 32%; p = 0.02). These effects were more pronounced in patients receiving dopamine agonists at baseline. Time to wearing off and motor scores were not significantly different, but trended in favor of LCE treatment. Patients in the LCE group received greater L‐dopa dose equivalents than LC‐treated patients (p < 0.001). Interpretation Initiating L‐dopa therapy with LCE failed to delay the time of onset or reduce the frequency of dyskinesia compared to LC. In fact, LCE was associated with a shorter time to onset and increased frequency of dyskinesia compared to LC. These results may reflect that the treatment protocol employed did not provide continuous L‐dopa availability and the higher L‐dopa dose equivalents in the LCE group. ANN NEUROL 2010;68:18–27

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Section: Discussionmentioning

confidence: 99%

Urachal carcinoma: Clinicopathologic features and long‐term outcomes of an aggressive malignancy

Ashley

Inman

Sebo

et al. 2006

Cancer

286

413

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“…The urachal remnant from the bladder apex tumor towards the umbilicus is not always identified, but it is a crucial finding establishing the diagnosis. Thali-Schwab et al analyzed the results of 25 CT examinations of urachal adenocarcinomas and reported that calcification is the characteristic sign of urachal adenocarcinoma, particularly urachal mucinous adenocarcinoma (8). In the cases reported herein, calcifications were also present.…”

Section: Discussionmentioning

confidence: 55%

Urachal carcinoma: Report of two cases and review of the literature

Quan

Pan

Jin

et al. 2016

Molecular and Clinical Oncology

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Abstract. Urachal carcinoma is a rare tumor that most commonly occurs in ovaries and less often in the adnexal region and urinary system. We herein present two cases of urachal carcinoma: One case was a 32-year-old male patient who presented with painless hematuria with blood clots for 1 month, whereas the other case was a 50-year-old woman who presented with gross hematuria with mild dysuria, urgency and frequent urination for 1 year. Following surgical resection, the two patients were diagnosed with urachal adenocarcinoma (mixed type) and urachal mucinous adenocarcinoma, respectively, based on the histopathological examination. A review of previously published cases and relevant literature is also presented. The aim of the present study was to help understand this disease better, in order to reduce the rate of clinical and pathological misdiagnosis. IntroductionUrachal carcinoma is a rare non-urothelial carcinoma, accounting for 0.01% of all malignancies and for 0.17-0.34% of all bladder tumors (1,2). Urachal carcinoma is more common among men, and the majority of the patients are aged >50 years (3). Although hematuria is the most common symptom, the disease is usually advanced when this symptom appears (4). As urachal carcinoma frequently invades the bladder at the dome or elsewhere along its midline, which is not easily detected during the early stages, it is often discovered late (5). Furthermore, there is currently no effective treatment for urachal carcinoma, leading to a poor prognosis. We herein report the cases of two patients with urachal carcinoma and urachal mucinous carcinoma. The relevant literature was also reviewed in order to help improve the diagnosis and treatment of this rare disease. Case reportsCase 1. The patient was a 32-year-old man who noted painless hematuria with blood clots for 1 month. There were no obvious precipitating or alleviating factors. On physical examination, there were no positive physical findings and the patient experienced no other discomfort. The results of the laboratory and imaging examinations (hemogram, urinalysis, prothrombin time, activated partial thromboplastin time, liver and kidney function tests and chest X-ray) were normal. However, urinary tract ultrasonography revealed an abnormal mixed signal at the bottom of the bladder. On further cystoscopy, only a small blood clot was detected. However, computed tomography (CT) revealed a circular hypodense mass located at the top and anterior part of the bladder, sized ~44x43 mm, without enlarged lymph nodes or other sign of metastatic disease (Fig. 1A).Following the doctors' recommendation, the patient consented to radical resection of the urachal tumor and partial cystectomy in August, 2015. We found that the lower part of the tumor was connected to the anterior wall of the bladder, whereas the upper part of the tumor was connected with the umbilical region. The tumor was sized ~7x8 cm. On gross pathological examination, the resected specimen was grey-yellow and gray-red, with a diameter of 6 cm. A small area co...

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“…Amyloidosisis another inflammatory condition that has been associated with urinary bladder calcification, albeitrarely 16 Urachal carcinoma is a rare pathology. Calcification within such tumors has previously been described 17 . If large enough, a calcified urachal carcinoma may be detectable as a calcific entity on plain film and may demonstrate acoustic shadowing on ultrasound.…”

Section: Fig: 1 Classifaction Of Urachal Anomaliesmentioning

confidence: 87%

Calcified Urachal Remnant Mimicking as Bladder Wall Calcification – Case Series

Parthasarathi¹,

Gautham²,

Pravin³

2014

jemds

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ABSTRACT:Computer tomography of kidneys, ureters and bladder (CT KUB) is the main investigation in suspected renal tract calculi. Ultrasound of kidneys, ureters and bladder (KUB) region can come in hand during acute conditions especially in patients with ureteric calculus causing hydronephrosis and hydroureter. However, several pathologies other than renal tract calculi can cause apparent urinary bladder calcification. We describe series of cases who presented with renal colic. CT KUB performed on admission revealed a calcified urachal remnant mimicking a urinary bladder wall calcification, confirmed by reviewing the multi-planar reformatted images. We also discuss the differential diagnoses that should be considered when presented with urinary bladder calcification. Our study shows urachus calcification is much more common in patients than previously taught and more common in older patients of more than 50 years than younger patients. Males are commonly affected than females.

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Computed tomographic appearance of urachal adenocarcinomas: review of 25 cases

Cited by 80 publications

References 9 publications

Urachal carcinoma: Clinicopathologic features and long‐term outcomes of an aggressive malignancy

Urachal carcinoma: Clinicopathologic features and long‐term outcomes of an aggressive malignancy

Urachal carcinoma: Report of two cases and review of the literature

Calcified Urachal Remnant Mimicking as Bladder Wall Calcification – Case Series

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