Computed tomographic findings of environmental asbestos‐related malignant pleural mesothelioma

Yılmaz, Ufuk; Utkaner, Gülay; Yalnız, Enver; Kumcuoglu, Z

doi:10.1046/j.1440-1843.1998.00069.x

Cited by 28 publications

(19 citation statements)

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“…The most frequent radiological features of MPM were pleural effusion and pleural thickening or nodularity. To sum up, the demographical, clinical and radiological characteristics in our series were similar to those in literature (Yilmaz et al, 1998;Wang et al, 2004).…”

Section: Discussionsupporting

confidence: 82%

Clinical Characteristics, Treatment and Survival Outcomes in Malignant Mesothelioma: Eighteen Years' Experience in Turkey

Berk

Doǧan²,

Kılıçkap³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: Malignant mesothelioma (MM) is an insidious tumor with poor prognosis, arising from mesothelial surfaces such as pleura, peritoneum and pericardium. We here aimed to evaluate the demographic, clinical, and radiological features of patients with MM followed in our center as well as their survival. Methods: The study included 228 patients (131 male, 97 female) who were followed up in our institution between 1993 and 2010 with the diagnosis of MM. Results: The mean age was 59.1 years in men and 58.7 years in women and the sex ratio was 1.4:1 in favor of males. Environmental asbestos exposure was present in 86% of the patients for a mean duration of 40±20 years (range: 3-70). Pleural effusion and thoracic/abdominal pain were the most common presenting signs and symptoms (70.2% and 57.8%, respectively). One hundred-thirteen (66%) patients were treated with platinum-based combination chemotherapy (PBCT) plus supportive care (SC) and 67 (34%) patients received SC alone. The median follow-up time was 10.0 months. The median overall survival was significantly improved with PBCT plus SC compared to SC alone (11.4 vs. 5.1 months; p=0.005). The 6, 12, 18, and 24-month survival rates were significantly improved with PBCT plus SC compared to SC alone (72%, 43%, 19%, and 2% vs. 49%, 31%, 11%, and 1%). Conclusion: The survival of patients with MM improved in patients treated with PBCT. The survival advantage continued 12-and 24-month after the initial time of combination chemotherapy.

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Section: Discussionsupporting

confidence: 82%

Clinical Characteristics, Treatment and Survival Outcomes in Malignant Mesothelioma: Eighteen Years' Experience in Turkey

Berk

Doǧan²,

Kılıçkap³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…More recently, Yılmaz et al [3]have documented thorax CT findings of environmental asbestos-related pleural mesothelioma in patients from various provinces of Turkey, and they suggested that CT is a useful tool to investigate these pathologies.…”

Section: Discussionmentioning

confidence: 99%

“…It has previously been reported that environmental asbestos exposure is common among the inhabitants of various districts of Turkey [1, 2, 3]. Yazıcıoğlu et al [1]have demonstrated that the prevalence of pleural plaques caused by environmental asbestos exposure is high among the residents of a number of towns surrounding Diyarbakır, a province in the southeast of Turkey.…”

Section: Introductionmentioning

confidence: 99%

High-Resolution Computed Tomography in Cases with Environmental Exposure to Asbestos in Turkey

Topçu

Bayram²,

Şimşek³

et al. 2000

Respiration

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Background and Objectives: Although all parts of the lung can be affected as a consequence of asbestos exposure, most CT protocols tend to scan only the middle and lower parts of the thorax. The aim of this study was to investigate parenchymal and pleural lesions of persons exposed to environmental asbestos, using a high-resolution computed tomography (HRCT) protocol scanning the whole thorax. Methods: We analyzed the chest radiographs and HRCT scans of 26 patients who presented bilaterally with multiple pleural plaques related to environmental asbestos exposure. Results: Twenty-four cases (92%) had an abnormal HRCT suggestive of asbestosis. Apart from common HRCT changes related to asbestosis, we detected apical pleural thickening (APT) in 9 cases as well as a coarse honeycomb pattern adjacent to APT in 7 of these cases. Cavitary lesions due to pulmonary tuberculosis were observed on HRCT scans from 4 patients in total. Neither apical pulmonary fibrosis nor cavitary lesions were visible on chest radiographs. Conclusions: We suggest that the HRCT protocol for examining asbestos-exposed individuals with pleural plaques on chest X-rays should include the whole thorax, since the asbestos-related pathologies may involve all parts of the lung.

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“…The disease is one of the major health problems in Turkey [3]. This is due to the many asbestos deposits which exist in some rural parts of central and eastern Anatolia [3, 4, 5]. The people living in the southeast of Turkey (ST) were also reported to have a high incidence of MPM due to environmental asbestos exposure [6, 7].…”

Section: Introductionmentioning

confidence: 99%

Incidence of Malignant Pleural Mesothelioma due to Environmental Asbestos Fiber Exposure in the Southeast of Turkey

Şenyiğit¹,

Babayiğit²,

Gökırmak

et al. 2000

Respiration

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Background: Inhabitants of the southeast of Turkey (ST) have been exposed since childhood to inhalation of asbestos, from a material containing tremolite, used for whitewashing. This has resulted in an increased incidence of malignant pleural mesothelioma (MPM). Objectives: To review the epidemiological features of MPM cases in ST; to calculate and compare the incidence with the previously reported ones. Subjects and Methods: The study included 176 MPM cases from different places in ST. The incidence of MPM was calculated for those places according to the distribution of the cases. Results: In the previously identified regions of asbestos (region 1) where the population had been informed of the danger with the soil some decades ago, the MPM incidence was decreased, as compared to the previous reports. The annual incidence of MPM in these places was found to be 42.9 per million in this study while it had been reported to be 105.5 per million in the previous studies. In contrast, the incidence that was reported previously to be 2.75 per million in the regions where asbestos exposure had not been identified before (region 2) was found to be 8.6 per million in this study. In region 2 the incidence of MPM increased even in the second half of the last decade (5.9 versus 11.9 per million). Conclusions: Use of asbestos-containing soil continues in different places in ST. Even if the use of this soil is abandoned today, MPM will be an important health problem in this region till the third or fourth decades of this century. Informing the villagers of the danger and preventing the use of this soil may result in a considerable decrease in the incidence of MPM.

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Computed tomographic findings of environmental asbestos‐related malignant pleural mesothelioma

Cited by 28 publications

References 1 publication

Clinical Characteristics, Treatment and Survival Outcomes in Malignant Mesothelioma: Eighteen Years' Experience in Turkey

Clinical Characteristics, Treatment and Survival Outcomes in Malignant Mesothelioma: Eighteen Years' Experience in Turkey

High-Resolution Computed Tomography in Cases with Environmental Exposure to Asbestos in Turkey

Incidence of Malignant Pleural Mesothelioma due to Environmental Asbestos Fiber Exposure in the Southeast of Turkey

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