High-Resolution Computed Tomography in Cases with Environmental Exposure to Asbestos in Turkey

Topçu, Füsun; Bayram, Hasan; Şimşek, Mikdat; Kaya, Kadir; Özcan, Ceyhan; Isik, Recep; Şenyiğit, Abdurrahman

doi:10.1159/000029501

Cited by 14 publications

(8 citation statements)

References 15 publications

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“…As in other studies (1), we found that pleural biopsy by needle was the most useful technique for the pathological diagnosis of MM (71.6%). Cytological examination had much less diagnostic value, in agreement with others (3,22).…”

Section: Discussionsupporting

confidence: 89%

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Evaluation of Malignant Mesothelioma in Central Anatolia: A Study of 67 Cases

Gülmez¹,

Kart

Büyükoğlan³

et al. 2004

Canadian Respiratory Journal

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BACKROUND: Malignant mesothelioma (MM) is a fatal neoplasm which frequently results from exposure to asbestos or erionite. METHOD: Sixty-seven patients with MM were seen between 1990 and 2001. Their clinical and radiological features, as well as the therapy, were retrospectively evaluated. RESULTS: In 51 patients (76.1%), the MM was confined to the pleura, in 14 patients it was exclusively peritoneal and in two patients, it involved both areas. Of the 67 cases, 35 (52.2%) were women. The mean (± SD) age for all cases was 57.6±11.5 years. Dyspnea (67.2%), cough (55.2%) and chest pain (50.7%) were the most frequent symptoms of onset. Pleural effusion (92.4%) was the most common chest x-ray finding, whereas pleural effusion (60.8%), pleural nodules (34.7%) and pleural thickening (34.7%) were the most common computed tomography findings in pleural MM patients. The histological subtypes of MM were determined as epithelial in 60 patients (89.5%), sarcomatous in four patients (5.9%) and mixed in three patients (4.4%). Although 50.7% and 25.4% of the cases were exposed to erionite and asbestos, respectively, 23.9% of the cases recalled no exposure to asbestos or erionite. Exposures were environmental as opposed to occupational. Thirty-five patients (52.2%) were administered chemotherapy, and follow-up data were available for 22 patients. For these patients, the two-year survival rate was 22% and the twoyear progression-free interval was 15.7%. There were no differences between patients with asbestos and erionite exposure. CONCLUSION: MM should be considered when exudative pleural effusion is detected in a patient who has been exposed to asbestos or erionite. MM is a major public health problem in parts of Turkey and compulsory environmental control of fibrous mineral should be considered.Key Words: Asbestos; Erionite; Malignant mesothelioma; Turkey L'évaluation du mésothéliome malin en Anatolie centrale : Une étude de 67 cas HISTORIQUE : Le mésothéliome malin (MM) est un néoplasme fatal qui découle souvent de l'exposition à l'amiante ou à l'érionite. MÉTHODOLOGIE : Soixante-sept patients atteints de MM ont été observés entre 1990 et 2001. Leurs caractéristiques cliniques et radiologiques, ainsi que leur traitement, ont fait l'objet d'une évaluation rétrospective. RÉSULTATS : Le MM était confiné à la plèvre chez 51 patients (76,1 %), au péritoine chez 14 patients, et il touchait les deux foyers chez deux patients. Des 67 cas , 35 (52,2 %) étaient des femmes. L'âge moyen (±ÉT) de tous les cas était de 57,6±11,5 ans. La dyspnée (67,2 %), la toux (55,2 %) et les douleurs thoraciques (50,7 %) étaient les symptômes d'apparition les plus fréquents. La radiographie thoracique la plus observée était une effusion pleurale (92,4 %), tandis qu'à la tomodensitométrie, on observait surtout une effusion pleurale (60,8 %), des nodules pleuraux (34,7 %) et un épaississement pleural (34,7 %) chez les patients atteints de MM de la plèvre. Les sous-types histologiques de MM étaient de nature épithéliale chez 60 patients (89,5 %), de nature...

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Section: Discussionsupporting

confidence: 89%

“…In Turkey, this disease is common in people born or living in certain villages in the central and the southeastern regions of the country (2,3).…”

mentioning

confidence: 99%

Evaluation of Malignant Mesothelioma in Central Anatolia: A Study of 67 Cases

Gülmez¹,

Kart

Büyükoğlan³

et al. 2004

Canadian Respiratory Journal

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“…It is used as a whitewash material for the walls and floors of the houses, and this procedure is repeated every year. Thus, householders are repeatedly exposed to asbestos fibers in their environment, from an early age [9, 10]. …”

Section: Introductionmentioning

confidence: 99%

Malignant Pleural Mesothelioma Caused by Environmental Exposure to Asbestos in the Southeast of Turkey: CT Findings in 117 Patients

Şenyiğit¹,

Bayram²,

Babayiğit³

et al. 2000

Respiration

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Background and Objectives: Malignant pleural mesothelioma (MPM) is reported to be common in the southeast of Turkey, as a result of environmental asbestos exposure. The aim of this study was to evaluate the computed tomography (CT) features of MPM in patients with a history of asbestos exposure. Methods: The CT scans of 117 patients who had a diagnosis of MPM were retrospectively evaluated. Additionally, CT findings of histologic subtypes were compared. Results: The most common CT findings included pleural effusion (n = 104, 89%), pleural thickening (n = 96, 82%), mediastinal pleural involvement (n = 77, 66%) and interlobar fissural involvement (n = 62, 53%). Histologic subtype analysis was performed in 89 patients; of these, epithelial, sarcomatous and mixed types were identified in 46, 23 and 20 patients, respectively. An analysis of CT findings demonstrated that the involvement of mediastinal pleural (91%), interlobar fissure (87%) and lung parenchyma (48%) was significantly more frequent in sarcomatous type, as compared to epithelial (61% and p < 0.01; 35 and 4%, p < 0.0001, respectively) and mixed types (65% and p < 0.05; 10% and p < 0.0001; 10% and p < 0.01, respectively). Furthermore, there was a significant correlation between pericardial involvement and chest wall involvement (r = 0.42, p < 0.05) in sarcomatous type. Similarly, lymphadenopathy and parenchymal involvement (r = 0.23, p < 0.02), pericardial and chest wall involvement (r = 0.25, p < 0.01), chest wall and interlobar fissural involvement (r = 0.25, p < 0.01) were significantly correlated, when CT findings of all histologic subtypes were combined. Conclusions: These results suggest that although CT findings of MPM vary, they may provide valuable clues to the diagnosis, at least in patients with a history of asbestos exposure. In addition, the presence of extensive lesions may suggest MPM of sarcomatous subtype.

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“…Since in the modern world people tend to move around it is also a necessity for doctors in other countries to be aware of the existence of specific medical problems in their patients’ home country. It is in this light that the article by Professor Topcu and his coworkers in this issue of Respiration [1]should be seen. …”

Section: Introductionmentioning

confidence: 99%

Environmental Dangers: Asbestos and Tuberculosis

Hillerdal¹

2000

Respiration

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High-Resolution Computed Tomography in Cases with Environmental Exposure to Asbestos in Turkey

Cited by 14 publications

References 15 publications

Evaluation of Malignant Mesothelioma in Central Anatolia: A Study of 67 Cases

Evaluation of Malignant Mesothelioma in Central Anatolia: A Study of 67 Cases

Malignant Pleural Mesothelioma Caused by Environmental Exposure to Asbestos in the Southeast of Turkey: CT Findings in 117 Patients

Environmental Dangers: Asbestos and Tuberculosis

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