Environmental Dangers: Asbestos and Tuberculosis

An association study of NRAMP1, VDR, MBL and their interaction with the susceptibility to tuberculosis in a Chinese population

“…2 It is suggested that the susceptibility to TB is multifactorial disease, influenced by many factors including HIV infection, environmental and host genetic factors. [19][20][21][22] Recently, various studies have been reporting that host genetic factors may play an important role in the susceptibility to TB. In our study, we investigated the association between the NRAMP1, MBL and VDR gene polymorphisms and their single and interaction in relation to the susceptibility to PTB and analyzed gene-gene interaction in Shanghai city.…”

FokI polymorphism of the vitamin D receptor (VDR) gene and susceptibility to tuberculosis: Evidence through a meta-analysis

“…Although, one third of the population of the world is infected with the bacillus but only a tiny percentage of the people may progress to active TB disease [2]. A number of factors are associated with the susceptibility of TB such asenvironmental [3], genetic [4], and HIV infection [5,6] etc. A number of studies were performed to determine the role of single nucleotide polymorphisms (SNPs) in the susceptibility of TB like-natural resistance-associated macrophage protein 1 (NRAMP1) gene [7], interleukin (IL) genes [8,9], vitamin D receptor (VDR) genes [10], and tumor necrosis factor (TNF) genes [11].…”