Computed tomographic perfusion imaging for the prediction of response and survival to transarterial chemoembolization of hepatocellular carcinoma

Popovič, Peter; Leban, Ana; Kregar, Klara; Garbajs, Manca; Dežman, Rok; Bunc, Matjaž

doi:10.1515/raon-2017-0052

Cited by 12 publications

(7 citation statements)

References 44 publications

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“…In this study, not only the mean value of perfusion parameters was analyzed, but also the percentiles of histogram analysis were calculated, which might be superior to median values for tumor grading and tumor recurrence evaluation. [ 28 , 31 ] The mean values, and the 10th, 50th, 75th, and 90th percentiles of HAC and AEF were significantly higher than the surrounding liver parenchyma, whereas the mean value, and the 10th, 50th, 75th, and 90th percentiles of PVC were significantly lower in the HCC tumor than the surrounding liver parenchyma, which was in line with previous findings. [ 32 – 34 ]…”

Section: Discussionsupporting

confidence: 89%

Heterogeneity analysis of triphasic CT scan perfusion parameters in differential diagnosis of hepatocellular carcinoma and hemangioma

Pang¹,

Duan

Shao

et al. 2018

Medicine

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This study is to investigate quantitative measures and heterogeneity of perfusion parameters in the differential diagnosis of hepatocellular carcinoma (HCC) and hemangioma.In total, 32 HCC and 44 hemangioma (types 1, 2, and 3) cases were included in this retrospective study. Hepatic artery coefficient (HAC), portal vein coefficient (PVC), and arterial enhancement fraction (AEF) were calculated. Tumor heterogeneity was analyzed. Perfusion parameters and corresponding percentiles were compared between the HCC and hemangioma (especially atypical hemangioma) cases, as well as between the substantial lesion part and surrounding normal tissue.The mean value, and the 10th, 50th, 75th, and 90th percentiles of PVC were significantly lower in the HCC cases than the types 1 and 2 hemangioma cases (P < .01). Moreover, the 90th percentile PVC in the HCC cases was also significantly lower than the type 3 hemangioma case (P < .01), while the mean value, and all the percentiles of AEF in the HCC cases were higher than the types 2 and 3 hemangioma cases (P < .01). The 10th percentile HAC in the HCC cases was higher than the type 2 hemangioma cases (P < .05). The mean value, and the 10th and 50th percentile HAC in the HCC cases were higher than the type 3 hemangioma case (P < .05). However, there was no statistically significant difference in HAC between the HCC and type 1 hemangioma cases (P > .05).Quantitative measurement of perfusion parameters and heterogeneity analysis show significance differences in the early detection and differential diagnosis of HCC and hemangioma cases, which might contribute to increasing the diagnostic accuracy.

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Section: Discussionsupporting

confidence: 89%

Heterogeneity analysis of triphasic CT scan perfusion parameters in differential diagnosis of hepatocellular carcinoma and hemangioma

Pang¹,

Duan

Shao

et al. 2018

Medicine

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“…Bai et al showed that CLTP values in the periphery of HCC lesions correlate with microvascular density on pathology, which is an important prognostic factor for HCC [ 110 ]. Multiple studies have validated CTLP as a non-invasive tool to predict and assess the response of HCC to locoregional and systemic treatment [ 111 , 112 , 113 , 114 , 115 , 116 ]. However, this subject remains out of the scope of this review.…”

Section: Ct Perfusionmentioning

confidence: 99%

Current Imaging Diagnosis of Hepatocellular Carcinoma

Chartampilas

Rafailidis

Georgopoulou

et al. 2022

Cancers

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Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer related death worldwide. Radiology has traditionally played a central role in HCC management, ranging from screening of high-risk patients to non-invasive diagnosis, as well as the evaluation of treatment response and post-treatment follow-up. From liver ultrasonography with or without contrast to dynamic multiple phased CT and dynamic MRI with diffusion protocols, great progress has been achieved in the last decade. Throughout the last few years, pathological, biological, genetic, and immune-chemical analyses have revealed several tumoral subtypes with diverse biological behavior, highlighting the need for the re-evaluation of established radiological methods. Considering these changes, novel methods that provide functional and quantitative parameters in addition to morphological information are increasingly incorporated into modern diagnostic protocols for HCC. In this way, differential diagnosis became even more challenging throughout the last few years. Use of liver specific contrast agents, as well as CT/MRI perfusion techniques, seem to not only allow earlier detection and more accurate characterization of HCC lesions, but also make it possible to predict response to treatment and survival. Nevertheless, several limitations and technical considerations still exist. This review will describe and discuss all these imaging modalities and their advances in the imaging of HCC lesions in cirrhotic and non-cirrhotic livers. Sensitivity and specificity rates, method limitations, and technical considerations will be discussed.

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“…Similar results were also found by Su et al in HCC patients treated with TACE. Results by Popovic et al 71 revealed that CTp could predict survival in patients with intermediate stage HCC treated with DEB-TACE. However, this technique was not able to assess response to treatment.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review on the Role of the Perfusion Computed Tomography in Abdominal Cancer

et al. 2021

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Background and purpose Perfusion Computed Tomography (CTp) is an imaging technique which allows quantitative and qualitative evaluation of tissue perfusion through dynamic CT acquisitions. Since CTp is still considered a research tool in the field of abdominal imaging, the aim of this work is to provide a systematic summary of the current literature on CTp in the abdominal region to clarify the role of this technique for abdominal cancer applications. Materials and Methods A systematic literature search of PubMed, Web of Science, and Scopus was performed to identify original articles involving the use of CTp for clinical applications in abdominal cancer since 2011. Studies were included if they reported original data on CTp and investigated the clinical applications of CTp in abdominal cancer. Results Fifty-seven studies were finally included in the study. Most of the included articles (33/57) dealt with CTp at the level of the liver, while a low number of studies investigated CTp for oncologic diseases involving UGI tract (8/57), pancreas (8/57), kidneys (3/57), and colon–rectum (5/57). Conclusions Our study revealed that CTp could be a valuable functional imaging tool in the field of abdominal oncology, particularly as a biomarker for monitoring the response to anti-tumoral treatment.

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Computed tomographic perfusion imaging for the prediction of response and survival to transarterial chemoembolization of hepatocellular carcinoma

Cited by 12 publications

References 44 publications

Heterogeneity analysis of triphasic CT scan perfusion parameters in differential diagnosis of hepatocellular carcinoma and hemangioma

Heterogeneity analysis of triphasic CT scan perfusion parameters in differential diagnosis of hepatocellular carcinoma and hemangioma

Current Imaging Diagnosis of Hepatocellular Carcinoma

A Systematic Review on the Role of the Perfusion Computed Tomography in Abdominal Cancer

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