Computed tomography colonography compared with conventional colonoscopy for the detection of colorectal polyps

Chaparro, María; Val, Lourdes del Campo; Jímenez, José; Perona, J Cantero; Barbosa, Antônio Vinícius Corrêa; Khorrami, Sam; Moreno–Otero, Ricardo; Gisbert, Javier P.

doi:10.1157/13108816

Cited by 11 publications

(5 citation statements)

References 31 publications

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“…We included 47 prospective studies involving 10,546 patients that compared CTC to the reference standard of CC or surgery [17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63]. Table 2 shows detailed information from individual studies.…”

Section: Resultsmentioning

confidence: 99%

Accuracy of Computed Tomographic Colonography for the Detection of Polyps and Colorectal Tumors: A Systematic Review and Meta-Analysis

et al. 2009

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Background: The real accuracy of computed tomographic colonography (CTC) is still unknown. Objective: To perform a meta-analysis of the diagnostic accuracy of CTC for the detection of polyps and colorectal tumors. Methods: Selection of studies:Studiesassessing the accuracy of CTC for the detection of colorectal polyps and tumors were selected. Data synthesis:Meta-analyses combining sensitivities, specificities and likelihood ratios (LRs) for the diagnosis of polyps and colorectal tumors were carried out. Results: Forty-seven studies, providing data of 10,546 patients, were included. Overall per-polyp sensitivity of CTC was 66% (64–68%), for polyps 6–9 mm in size it was 59% (56–61%), and 76% (73–79%) for polyps larger than 9 mm. Overall per-patient sensitivity was 69% (66–72%), for polyps 6–9 mm 60% (56–65%), and 83% (70–85%) for lesions larger than 9 mm. Overall CTC specificity was 83% (81–84%). Positive and negative LRs were 2.9 (1.8–4) and 0.38 (0.27–0.53), respectively; for polyps 6–9 mm in size, they were 3.8 (2.5–5.7) and 0.4 (0.27–0.59), and 12.3 (7.7–19.4) and 0.19 (0.12–0.3) for polyps larger than 9 mm. Conclusion: CTC is highly specific for the detection of colorectal polyps and tumors. Some studies reported high sensitivities, but the results of the studies were highly heterogeneous, while the studied variables explained only part of this discrepancy.

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Section: Resultsmentioning

confidence: 99%

Accuracy of Computed Tomographic Colonography for the Detection of Polyps and Colorectal Tumors: A Systematic Review and Meta-Analysis

et al. 2009

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“…A total of 5131 articles were retrieved by the electronic search after excluding duplications. Ultimately, based on the inclusion and exclusion criteria, 14 full‐text articles [6‐7,15‐26], including 15 studies, were included in the meta‐analysis. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) flow diagram of retrieved studies is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…In this meta‐analysis, written informed consent was obtained from all the participants in the included studies, and all visible lesions were removed during colonoscopy. Some of the included studies in our meta‐analysis [6,15‐16,23‐26] reported that CTC performed well in patients at increased risk for CRC, and there were no complications or serious adverse events recorded in relation to either the CTC preparation or examination. However, others [7,17,22] reported that some participants who underwent CTC had some side effects, such as headache, nausea, vomiting, cramps, dizziness, palpitations etc.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown that colonoscopy with polypectomy is associated with a strongly reduced risk for CRC [3‐5]. Conventional colonoscopy (CC), which allows operators to have a direct view of any visible lesion, to perform biopsies and to remove suspicious polyps efficiently, is a widely accepted method for the diagnosis and prevention of CRC [6] and is a key tool in reducing CRC mortality. Unfortunately, colonoscopy is an invasive procedure which may be painful and unpleasant [7].…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy of computed tomography colonography in patients at high risk for colorectal cancer: a meta‐analysis

Bai

Zhu

et al. 2020

Colorectal Disease

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Aim The aim was to explore the diagnostic value of computed tomographic colonography (CTC) compared with conventional colonoscopy in individuals at high risk for colorectal cancer. Method PubMed, Embase, the Cochrane Library and the Web of Science were searched by two independent reviewers for potentially eligible studies published up to 31 October 2018 that were based on a per-patient analysis. STATA, META-DISC and REVMAN were used to perform this meta-analysis. A random-effect model was used, and a subgroup analysis was conducted to explore the sources of heterogeneity. Results A total of 14 full-text articles, involving 3578 patients, were included in this meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and the area under the summary receiver operating characteristic curve of CTC for detecting polyps ≥ 6 mm were 0.87 (95% CI 0.83-0.90), 0.90 (95% CI 0.86-0.93), 9.08 (95% CI 6.28-13.13), 0.14 (95% CI 0.11-0.18) and 0.94 (95% CI 0.92-0.96), respectively. For polyps ≥ 10 mm, the pooled sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of CTC were 0.91 (95% CI 0.86-0.94), 0.98 (95% CI 0.95-0.99), 40.36 (95% CI 19.16-85.03), 0.90 (95% CI 0.06-0.14) and 0.98 (95% CI 0.96-0.99), respectively. Conclusion In this meta-analysis, CTC had high diagnostic accuracy for detecting polyps ≥ 6 mm and ≥ 10 mm in patients at high risk of developing colorectal cancer and it had a higher sensitivity and specificity for detecting polyps ≥ 10 mm than polyps ≥ 6 mm. However, the results should be used cautiously due to the significant heterogeneity.

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“…These results are similar to those reported by Pineau et al [ 22 ], Laghi et al [ 15 ], and Hoppe et al [ 26 ]. Additionally, Chaparro Sánchez et al [ 27 ] found that the sensitivity of CTC for the detection of colorectal lesions was highly variable and dependent on the lesion size: sensitivity was greater for larger lesions and considerably lower for lesions <5 mm. Flat lesions are difficult to detect with CTC because the conspicuity of flat lesions on three-dimensional endoluminal imaging is diminished, frequently resulting in false-negative findings [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Can Computed Tomography Colonography Replace Optical Colonoscopy in Detecting Colorectal Lesions?: State of the Art

et al. 2022

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Colorectal cancer is an important cause of morbidity and mortality worldwide. Optical colonoscopy (OC) is widely accepted as the reference standard for the screening of colorectal polyps and cancers, and computed tomography colonography (CTC) is a valid alternative to OC. The purpose of this review was to assess the diagnostic accuracy of OC and CTC for colorectal lesions. A literature search was performed in PubMed, Embase, and Cochrane Library, and 18 articles were included. CTC has emerged in recent years as a potential screening examination with high accuracy for the detection of colorectal lesions. However, the clinical application of CTC as a screening technique is limited because it is highly dependent on the size of the lesions and has poor performance in detecting individual lesions <5 mm or flat lesions, which, although rarely, can have a malignant potential. Clin Endosc 2022 Feb 24.

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Computed tomography colonography compared with conventional colonoscopy for the detection of colorectal polyps

Cited by 11 publications

References 31 publications

Accuracy of Computed Tomographic Colonography for the Detection of Polyps and Colorectal Tumors: A Systematic Review and Meta-Analysis

Accuracy of Computed Tomographic Colonography for the Detection of Polyps and Colorectal Tumors: A Systematic Review and Meta-Analysis

Diagnostic accuracy of computed tomography colonography in patients at high risk for colorectal cancer: a meta‐analysis

Can Computed Tomography Colonography Replace Optical Colonoscopy in Detecting Colorectal Lesions?: State of the Art

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