Computed tomography of xanthogranulomatous cholecystitis

Af, Cossi; Fj, Scholz; Ht, Aretz; Cr, Larsen

doi:10.1007/bf01885128

Cited by 16 publications

(3 citation statements)

References 5 publications

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“…The importance of this disease is that, clinically and radiologically, it simulates gallbladder carcinoma [31,32]. Chun et al described how in most cases, there is a statistically significant overlap of CT features between XGC and gallbladder carcinomas, and that if intramural hypoattenuated nodules are not seen at CT, differentiation of XGC from gallbladder carcinoma may be difficult or impossible [33].…”

Section: Benign Lesionsmentioning

confidence: 98%

Differential diagnosis of gallbladder cancer using positron emission tomography with fluorine‐18‐labeled fluoro‐deoxyglucose (FDG‐PET)

Koh

Taniguchi

Yamaguchi³

et al. 2003

Journal of Surgical Oncology

105

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Section: Benign Lesionsmentioning

confidence: 98%

Differential diagnosis of gallbladder cancer using positron emission tomography with fluorine‐18‐labeled fluoro‐deoxyglucose (FDG‐PET)

Koh

Taniguchi

Yamaguchi³

et al. 2003

Journal of Surgical Oncology

105

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“…Although, it is a benign condition, it behaves in an aggressive manner and mimics malignancy in its clinical presentation, roentgenographic findings and even in gross operative appearance [7]. …”

Section: Discussionmentioning

confidence: 99%

Xanthogranulomatous Cholecystitis: Catching the Culprit – Clinical and Imaging Analysis

Jain

Saluja²,

Sharma³

et al. 2012

Dig Surg

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Background: Radiological and intraoperative findings of xanthogranulomatous cholecystitis (XGC) mimic carcinoma gallbladder (CaGB) leading to extended surgical resections and increased morbidity. We reviewed the clinical and CECT findings of histopathologically proven XGC and compared them with those of CaGB. Methods: The clinical and CECT findings from 22 patients with XGC were compared with 15 patients with CaGB manifesting as diffuse wall thickening. Results: GB wall thickness was similar in both groups (XGC 12.4 ± 3 mm, CaGB 13.9 ± 6.5 mm; p = 0.61). Intramural hypoattenuating nodules occupying >60% of the GB wall were suggestive of XGC, while the absence of nodules suggested CaGB (p = 0.017). The mucosal lining was intact and enhancing in XGC (20/22) and disrupted in CaGB (10/15; p = 0.001). Among adjacent organ infiltration, bile duct invasion resulting in obstruction was a significant finding in patients with CaGB (p = 0.04). Among XGC patients, 11 patients underwent radical cholecystectomy, 10 had open cholecystectomy and frozen section and 1 underwent bypass. Conclusions: Though there is an overlap between XGC and CaGB, the presence of intramural hypoattenuating nodules occupying >60% of the diffusely thickened GB wall with intact mucosal line and the absence of obstructive features suggest XGC. In the presence of such imaging features, frozen biopsy should be done before proceeding with mutilating radical surgery.

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“…12,14 Although XGC is unusual and accounts for 0.7%-13.2% of all cholecystitis cases, 15,16 it has attracted attention recently because it is often misdiagnosed as gallbladder carcinoma. It was previously reported that CT findings of XGC were intramural hypoattenuated nodules with a mucosal line in the gallbladder wall, 17,18 a soft tissue mass in the region of the gallbladder, 19 a gallbladder with an irregular, sometimes lobulated, greatly thickened wall, 20 and poorly defined borders of the underlying liver and/ or the adjacent organs. 16,21 B-mode ultrasonography showed hypo-echoic nodules and a low-level echo band that are the most characteristic features of XGC; 17 however, these findings mimic carcinoma in most cases and in fact, in our case, we could not exclude the irregular thickened wall from being malignant.…”

Section: Discussionmentioning

confidence: 99%

Expression of GLUT-1 and GLUT-3 in Xanthogranulomatous Cholecystitis Induced a Positive Result on 18F-FDG PET: Report of a Case

Sawada

Shimada

Sekine

et al. 2013

International Surgery

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Although several reports have revealed that fluorine-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) is useful for differentiating between benign and malignant lesions in the gallbladder, the positive results of (18)F-FDG PET are not specific for malignancy because (18)F-FDG is also accumulated in inflammatory lesions. It is known that the most important pathway for (18)F-FDG to enter the cell body is mediated by the facilitative glucose transporter-1 (GLUT-1) through GLUT-3. We herein present a case of xanthogranulomatous cholecystitis (XGC) with a positive result on (18)F-FDG PET. In this case, GLUT-1 and GLUT-3 were both positively expressed in inflammatory cells at the gallbladder wall of XGC and this is the first report to reveal GLUT expression in XGC. This report reveals that surgeons should carefully consider the appropriate treatment of gallbladder tumor, even with a positive result on (18)F-FDG PET.

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Computed tomography of xanthogranulomatous cholecystitis

Abstract: A case is presented of xanthogranulomatous cholecystitis that resembled carcinoma of the gallbladder on computed tomography. The large, infiltrating mass satisfied the criteria for massive carcinoma of the gallbladder.

Cited by 16 publications

References 5 publications

Differential diagnosis of gallbladder cancer using positron emission tomography with fluorine‐18‐labeled fluoro‐deoxyglucose (FDG‐PET)

Differential diagnosis of gallbladder cancer using positron emission tomography with fluorine‐18‐labeled fluoro‐deoxyglucose (FDG‐PET)

Xanthogranulomatous Cholecystitis: Catching the Culprit – Clinical and Imaging Analysis

Expression of GLUT-1 and GLUT-3 in Xanthogranulomatous Cholecystitis Induced a Positive Result on 18F-FDG PET: Report of a Case

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