Computer‐aided diagnosis in high resolution CT of the lungs

Sluimer, Ingrid C.; Waes, P F van; Viergever, Max A.; Ginneken, Bram van

doi:10.1118/1.1624771

Cited by 129 publications

(111 citation statements)

References 25 publications

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“…6,7 ROIs of 100 Â 25 pixels were selected to characterize the healthy bone. It was the minimum area that included only one kind of tissue (cortical, trabecular, or flat bone).…”

Section: Regions Of Interestmentioning

confidence: 99%

A Complementary Method for the Detection of Osteoblastic Metastases on Digitized Radiographs

González-Sistal

Sánchez

2006

J Digit Imaging

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Purpose: This study was conducted to evaluate the diagnostic usefulness of gray level parameters in order to distinguish healthy bone from osteoblastic metastases on digitized radiographs. Materials and methods: Skeletal radiographs of healthy bone (n = 144) and osteoblastic metastases (n = 35) were digitized using pixels 0.175 mm in size and 4,096 gray levels. We obtained an optimized healthy bone classification to compare with pathological bone: cortical, trabecular, and flat bone. The osteoblastic metastases (OM) were classified in nonflat and flat bone. These radiological images were analyzed by using a computerized method. The parameters (gray scale) calculated were: mean, standard deviation, and coefficient of variation (MGL, SDGL, and CVGL, respectively) based on gray level histogram analysis. Diagnostic utility was quantified by measurement of parameters on healthy and pathological bone, yielding quantification of area under the receiver operating characteristic (ROC) curve, AUC. Results: All three image parameters showed high and significant values of AUC when comparing healthy trabecular bone and nonflat bone OM, showing MGL the best discriminatory ability (0.97). As for flat bones, MGL showed no ability to distinguish between healthy and flat bone OM (0.50). This could be achieved by using SDGL or CVGL, with both showing a similar diagnostic ability (0.85 and 0.83, respectively). Conclusion: Our results show that the use of gray level parameters quantify healthy bone and osteoblastic metastases zones on digitized radiographs. This may be helpful as a complementary method for differential diagnosis. Moreover, our method will allow us to study the evolution of osteoblastic metastases under medical treatment.

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“…6,7 ROIs of 100 Â 25 pixels were selected to characterize the healthy bone. It was the minimum area that included only one kind of tissue (cortical, trabecular, or flat bone).…”

Section: Regions Of Interestmentioning

confidence: 99%

A Complementary Method for the Detection of Osteoblastic Metastases on Digitized Radiographs

González-Sistal

Sánchez

2006

J Digit Imaging

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“…In this study, the 3D LBP-TOP uses three orthogonal planes that intersect in the center voxel 5 as shown in Figure 11. www.ijacsa.thesai.org In the experiment we select 4 and 8 neighbors with 1 voxel radius as a local neighborhood.…”

Section: ) Small Cell Carcinoma (6 Patients) 2) Tubercoluma Of the Lmentioning

confidence: 99%

“…[2,3,4] uses measures on co-occurrence matrices, measures on run-length matrices, moments of the attenuation or intensity histogram, and in some cases fractal dimension as features. Sluimer et al [5] used a filter bank of Gaussians and Gaussian derivatives.…”

Section: Introductionmentioning

confidence: 99%