Computer Assisted Thermal Complexation Studies of Vanadium with Benzodiazepine Drugs

Abstract

The complexing tendency of vanadium with nifoxipam and lorazepam were carried out by pH metric titration technique in aqueous acid media at different temperatures (298, 308 and 318 K) and an ionic strength of 0.2 M. The degree of complexation was investigated at different pH values. Potentionmetric measurement of hydrogen ion concentration was also studied with the degree of complex formation. The proton-ligand and metal-ligand stability constants were resolved by modified Calvin-Bjerrum pH titration technique (Irving and Rossitti) using computer programming. The important thermodynamic parameters such as Gibb's free energy change (ΔG), entropy change (ΔS) and enthalpy change (ΔH) for the complexation reactions were calculated. The formation of metal complexes was found to be spontaneous, exothermic and conducive in nature at lower temperatures.

Untitled

“…The shelf-life of a drug is the duration of time in which, under labeled storage conditions, it retains all its important characteristics within specific prescribed limits. [22] Its estimation guarantees the efficacy and quality of medicine and establishes its expiry time. As per ancient Ayurvedic texts, recommended shelf-life of Ghrita preparations is from 6 months to 2.…”

Mild Chemo-Photothermal Synergistic Therapy for Tumors Based on Gold-Nanoparticles Coupled with Metformin

“…Therefore, combining PTT with MET chemotherapy may have the potential to improve the anti-tumor efficacy of MET chemotherapy. However, it is worth noting that MET has poor thermal stability, as 10% of MET can be decomposed in 208 h at 30 °C, and the decomposition process further accelerates with the increase in temperature . The traditional chemo-photothermal therapy depending on high temperatures to achieve tumor-killing may not be suitable for the co-therapy of MET and PTT (MET-PTT).…”

“…However, it is worth noting that MET has poor thermal stability, as 10% of MET can be decomposed in 208 h at 30 °C, and the decomposition process further accelerates with the increase in temperature. 13 The traditional chemo-photothermal therapy depending on high temperatures to achieve tumor-killing may not be suitable for the co-therapy of MET and PTT (MET-PTT). It is reported that hyperthermia up to almost 50 °C is needed for tumor cell necrosis, which could cause side effects to the peripheral normal tissue.…”