“…Because this technique generated a range of surface displacements for the w3,000 points, frequency histograms were created to compare the percentage of the surface at vector differences between 1 mm and 15 mm. This method also reported surface area (SA) of the volumes, which was combined with organ volume (V) to calculate a measure of surface sphericity index (SSI) for the contours [20]: SSI ¼ SA 1.5 /V. Values for the index close to 1 indicate perfect sphericity, values greater than 1 indicate the presence of surface irregularities.…”