Computer Vision Malaria Diagnostic Systems—Progress and Prospects

Pollak, Joseph Joel; Houri-Yafin, Arnon; Salpeter, Seth J.

doi:10.3389/fpubh.2017.00219

Cited by 17 publications

(10 citation statements)

References 45 publications

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“…The results of one-way sensitivity analysis also indicated that RDT would dominate microscopy in other specific scenarios, such as, when the proficiency of laboratory personnel decreased, and salary increased. Than the image recognition based on artificial intelligence is likely to reduce labor costs and maintain the accuracy of microscopy [34,35]. But for now, it was difficult to for microscopy to have a higher sensitivity compared to RDT.…”

Section: Discussionmentioning

confidence: 99%

Cost-effectiveness analysis of malaria rapid diagnostic test in the elimination setting

Ling

Jin

et al. 2020

Infect Dis Poverty

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Background As more and more countries approaching the goal of malaria elimination, malaria rapid diagnostic tests (RDT) was recomendated to be a diagnostic strategy to achieve and maintain the statute of malaria free, as it’s less requirments on equipment and experitise than microscopic examination. But there are very few economic evaluations to confirm whether RDT was cost-effective in the setting of malaria elimination. This research aimed to offer evidence for helping decision making on malaria diagnosis strategy. Methods A cost-effectiveness analysis was conducted to compare RDT with microscopy examination for malaria diagnosis, by using a decision tree model. There were three strategies of malaria diagnostic testing evaluated in the model, 1) microscopy, 2) RDT, 3) RDT followed by microscopy. The effect indicator was defined as the number of malaria cases treated appropriately. Based on the joint perspective of health sector and patient, costs data were collected from hospital information systems, key informant interviews, and patient surveys. Data collection was conducted in Jiangsu from September 2018 to January 2019. Epidemiological data were obtained from local malaria surveillance reports. A hypothetical cohort of 300 000 febrile patients were simulated to calculate the total cost and effect of each strategy. One-way, two-way, and probabilistic sensitivity analysis were performed to test the robustness of the result. Results The results showed that RDT strategy was the most effective (245 cases) but also the most costly (United States Dollar [USD] 4.47 million) compared to using microscopy alone (238 cases, USD 3.63 million), and RDT followed by microscopy (221 cases, USD 2.75 million). There was no strategy dominated. One-way sensitivity analysis reflected that the result was sensitive to the change in labor cost and two-way sensitivity analysis indicated that the result was not sensitive to the proportion of falciparum malaria. The result of Monte Carlo simulation showed that RDT strategy had higher effects and higher cost than other strategies with a high probability. Conclusions Compared to microscopy and RDT followed by microscopy, RDT strategy had higher effects and higher cost in the setting of malaria elimination.

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Section: Discussionmentioning

confidence: 99%

Cost-effectiveness analysis of malaria rapid diagnostic test in the elimination setting

Ling

Jin

et al. 2020

Infect Dis Poverty

View full text Add to dashboard Cite

show abstract

“…The results of one-way sensitivity analysis also indicated that RDT would dominate microscopy in other specific scenarios, such as, when the proficiency of laboratory personnel decreased, and salary increased. Than the image recognition based on artificial intelligence is likely to reduce labor costs and maintain the accuracy of microscopy [33,34]. But for now, it was difficult to for microscopy to have a higher sensitivity compared to RDT.…”

Section: Discussionmentioning

confidence: 99%

Cost-effectiveness analysis of malaria rapid diagnostic test in the elimination setting

Ling

Jin

et al. 2020

Preprint

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Background As more and more countries approaching the goal of malaria elimination, malaria rapid diagnostic tests (RDT) was recomendated to be a diagnostic strategy to achieve and maintain the statute of malaria free, as it’s less requirments on equipment and experitise than microscopic examination. But there are very few economic evaluations to confirm whether RDT was cost-effective in the setting of malaria elimination. Methods A cost-effectiveness analysis, based on data from Jiangsu province, China, was conducted to compare RDT with microscopy examination for malaria diagnosis. There were three strategies of malaria diagnostic testing evaluated using a decision tree model, 1) microscopy, 2) RDT, 3) RDT followed by microscopy. The effects were measured by the number of malaria cases treated appropriately. Based on the joint perspective of health sector and patient, costs data were collected from hospital information systems, key informant interviews, and patient surveys. Epidemiological data were obtained from local malaria surveillance reports. A hypothetical cohort of 300,000 febrile patients were simulated to calculate the total cost and effect of each strategy. One-way, two-way, and probabilistic sensitivity analysis were performed to test the robustness of the result. Results The results showed that RDT strategy was the most effective (245 cases) but also the most costly (4.47 million USD) compared to using microscopy alone (238 cases, 3.63 million USD), and RDT followed by microscopy (221 cases, 2.75 million USD). There was no strategy dominated. One-way sensitivity analysis reflected that the result was sensitive to the change in labor cost and two-way sensitivity analysis indicated that the result was not sensitive to the proportion of falciparum malaria. The result of Monte Carlo simulation showed that RDT strategy had higher effects and higher cost than other strategies with a high probability. Conclusions Compared to microscopy and RDT followed by microscopy, RDT strategy had higher effects and higher cost in the setting of malaria elimination. This conclusion still would be held when the change in the proportion of falciparum and the cost fluctuations were accounted.

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“…In recent years, more and more targets for detection on diagnostic chips have been investigated. Some salient examples thereof are circulating tumor cells (CTC) of various types of cancer [1,[36][37][38], rare cells (e.g., sickle-cell variants of red blood cells) [39,40], parasites, like Plasmodium falciparum [1,7,10,11,[13][14][15][21][22][23]36,[41][42][43][44][45][46][47][48][49][50] and Trypanosoma spp. [8,44,[51][52][53][54][55][56][57] and even plant pathogens [26,58], as well as-after cells have been lysed-subcellular infection markers (e.g., DNA, RNA fragments) [10,11,22,43,[59][60][61][62].…”

Section: What We Can Detectmentioning

confidence: 99%

Lab-on-a-Chip Technologies for the Single Cell Level: Separation, Analysis, and Diagnostics

Hochstetter

2020

Micromachines

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In the last three decades, microfluidics and its applications have been on an exponential rise, including approaches to isolate rare cells and diagnose diseases on the single-cell level. The techniques mentioned herein have already had significant impacts in our lives, from in-the-field diagnosis of disease and parasitic infections, through home fertility tests, to uncovering the interactions between SARS-CoV-2 and their host cells. This review gives an overview of the field in general and the most notable developments of the last five years, in three parts: 1. What can we detect? 2. Which detection technologies are used in which setting? 3. How do these techniques work? Finally, this review discusses potentials, shortfalls, and an outlook on future developments, especially in respect to the funding landscape and the field-application of these chips.

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Computer Vision Malaria Diagnostic Systems—Progress and Prospects

Cited by 17 publications

References 45 publications

Cost-effectiveness analysis of malaria rapid diagnostic test in the elimination setting

Cost-effectiveness analysis of malaria rapid diagnostic test in the elimination setting

Cost-effectiveness analysis of malaria rapid diagnostic test in the elimination setting

Lab-on-a-Chip Technologies for the Single Cell Level: Separation, Analysis, and Diagnostics

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