Computerized cognitive training and functional recovery in major depressive disorder: A meta-analysis

Motter, Jeffrey N.; Pimontel, Monique A.; Rindskopf, David; Devanand, Davangere P.; Doraiswamy, P. Murali; Sneed, Joel R.

doi:10.1016/j.jad.2015.09.022

Cited by 264 publications

(227 citation statements)

References 49 publications

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“…In sum, although some studies have failed to find effects of CCT on rumination and depressive symptomatology in MDD samples, most CCT studies have yielded promising effects in MDD samples in terms of reducing cognitive vulnerability for depression (see Supplemental material Table 2). This is in line with recent meta-analytical findings confirming the beneficial effects of cognitive training on working memory functioning, symptom severity, and daily functioning in depression (Motter et al, 2016), with effects on these outcome measures ranging from small to moderate. Although such results suggest that effects of CCT may complement effects of antidepressant treatments and TAU, no additional effects were found when combining CCT with a brief behavior activation protocol.…”

Section: Cognitive Control Training In Mdd Samplessupporting

confidence: 91%

“…This, in its turn, may have led to an initial overestimation of training effects, although more recent studies comparing training procedures of similar intensity with adequate control conditions have observed similar effectsizes in at-risk and patient samples (e.g., Hoorelbeke & Koster, 2017;Hoorelbeke, Koster, Vanderhasselt, Callewaert, & Demeyer, 2015). Importantly, this is in line with recent metaanalytical findings regarding effects of general cognitive training in depression (Motter et al, 2016). Another factor that seems to be important in observing transfer is task engagement / motivation (e.g., Siegle et al, 2014), where studies may benefit from explicitly framing training procedures (and active control trainings) as interventions (e.g., using psychoeducation).…”

Section: Critical Appraisal Of the Evidencesupporting

confidence: 70%

“…However, the recent meta-analysis by Motter et al (2016) indicated decreased effects of CCT with increasing age. Furthermore, Motter et al (2016) found no moderating effects of gender or medication status.…”

Section: Analysis Of Moderating Factorsmentioning

confidence: 99%

“…Although in its infancy, this research domain is rapidly expanding with recent meta-analytic evidence suggesting beneficial effects of cognitive training on depression outcomes (Motter et al, 2016). However, existing studies strongly differ in training procedures deployed, intensity of training, comparison groups, outcomes, and quality of the research designs in general.…”

Section: Introductionmentioning

confidence: 99%

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Cognitive control interventions for depression: A systematic review of findings from training studies

Koster

Hoorelbeke

Onraedt

et al. 2017

Clinical Psychology Review

212

159

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There is a strong interest in cognitive control training as a new intervention for depression.Given the recent promising meta-analytical findings regarding the effects of cognitive training on cognitive functioning and depressive symptomatology, the current review provides an indepth discussion of the role of cognitive control in depression. We consider the state-of-theart research on how manipulation of cognitive control may influence cognitive and depression-related outcomes. Evidence for the effectiveness of cognitive control training procedures are discussed in relation to three stages of depression (at-risk, clinically depressed, remission) as well as the training approach that was deployed, after which the putative theoretical mechanisms are discussed. Finally, we provide ways in which cognitive control training can be utilized in future research.COGNITIVE CONTROL TRAINING FOR DEPRESSION 3

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Section: Cognitive Control Training In Mdd Samplessupporting

confidence: 91%

Section: Critical Appraisal Of the Evidencesupporting

confidence: 70%

Section: Analysis Of Moderating Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cognitive control interventions for depression: A systematic review of findings from training studies

Koster

Hoorelbeke

Onraedt

et al. 2017

Clinical Psychology Review

212

159

View full text Add to dashboard Cite

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“…Interest in applying digital technologies to psychiatric practice has been increasing since the early 2000s, and recommendations for future research in this area were issued in 2013 by a technical expert panel convened by the Agency for Healthcare Research and Quality and the National Institute of Mental Health [10][11][12]. Examples of interventions that have used DHTs in patients with SMI include ecological momentary assessment and treatment interventions [13], computerized psychotherapies [14], cognitive remediation [15,16], family psychoeducation interventions [17], and interventions specifically targeting medication adherence [18].…”

Section: The Potential Of Digital Health Tools For Psychiatric Practicementioning

confidence: 99%

Expert Consensus Survey on Digital Health Tools for Patients With Serious Mental Illness: Optimizing for User Characteristics and User Support (Preprint)

Hatch¹,

Hoffman²,

Ross³

et al. 2018

Preprint

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Background: Digital technology is increasingly being used to enhance healthcare in various areas of medicine. In the area of serious mental illness (SMI), it is important to understand the special characteristics of target users that may influence motivation and competence to use digital health tools (DHTs), as well as the resources and training necessary for these patients to facilitate the use of this technology. Objective: To conduct a quantitative expert consensus survey to identify key characteristics of target users (patients and healthcare professionals [HCPs]), barriers and facilitators for appropriate use, and resources needed to optimize the use of DHTs in patients with SMI. Methods: A panel of 40 experts in digital behavioral health who met the participation criteria completed a 19-question survey rating predefined responses on a 9-point Likert scale. Consensus was determined using a chi-square test of score distributions across 3 ranges (1-3, 4-6, 7-9). Categorical ratings of first, second, or third line were designated based on the lowest category into which the confidence interval of the mean ratings fell, with a boundary >6.5 for first line. Here, we report experts' responses to 9 questions (265 options) that focused on (1) user characteristics that would promote or hinder the use of DHTs, (2) potential benefits/motivators and barriers/unintended consequences of DHT use, and (3) support and training for patients and HCPs. Results: Among patient characteristics most likely to promote use of DHTs, experts endorsed interest in using state-of-the-art technology, availability of necessary resources, good occupational functioning, and perception of the tool as beneficial. Certain diseaseassociated signs and symptoms (eg, more severe symptoms, substance abuse problems, a chaotic living situation) were considered likely to make it difficult for patients to use DHTs. Enthusiasm among HCPs for DHTs and availability of staff and equipment to support their use were identified as variables to enable HCPs to successfully incorporate DHTs into their practices. The experts identified a number of potential benefits of and barriers to use of DHTs by patients and HCPs. Most experts agreed that both HCPs and patients would need to be trained in the use of these new technologies. Conclusions: These results provide guidance to the mental health field on how to optimize the development and deployment of DHTs for patients with SMI.

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Improving late life depression and cognitive control through the use of therapeutic video game technology: A proof-of-concept randomized trial

2017

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Background Existing treatments for depression are known to have only modest effects, are insufficiently targeted, and are inconsistently utilized, particularly in older adults. Indeed, older adults with impaired cognitive control networks tend to demonstrate poor response to a majority of existing depression interventions. Cognitive control interventions delivered using entertainment software have the potential to not only target the underlying cerebral dysfunction associated with depression, but to do so in a manner that is engaging and engenders adherence to treatment protocol. Methods In this proof-of-concept trial (Clinicaltrials.gov #: NCT02229188), individuals with late life depression (LLD) (22; 60+ years old) were randomized to either problem solving therapy (PST, n = 10) or a neurobiologically inspired digital platform designed to enhance cognitive control faculties (Project: EVO™, n = 12). Given the overlapping functional neuroanatomy of mood disturbances and executive dysfunction, we explored the impact of an intervention targeting cognitive control abilities, functional disability, and mood in older adults suffering from LLD, and how those outcomes compare to a therapeutic gold standard. Results EVO participants demonstrated similar improvements in mood and self-reported function after 4 weeks of treatment to PST participants. The EVO participants also showed generalization to untrained measures of working memory and attention, as well as negativity bias, a finding not evident in the PST condition. Individuals assigned to EVO demonstrated 100% adherence. Conclusions This study provides preliminary findings that this therapeutic video game targeting cognitive control deficits may be an efficacious LLD intervention. Future research is needed to confirm these findings.

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Computerized cognitive training and functional recovery in major depressive disorder: A meta-analysis

Cited by 264 publications

References 49 publications

Cognitive control interventions for depression: A systematic review of findings from training studies

Cognitive control interventions for depression: A systematic review of findings from training studies

Expert Consensus Survey on Digital Health Tools for Patients With Serious Mental Illness: Optimizing for User Characteristics and User Support (Preprint)

Improving late life depression and cognitive control through the use of therapeutic video game technology: A proof-of-concept randomized trial

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